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Process for preparing 1,3-propylene glycol and dihydroxy acetone by bio-catalytic conversion of glycerol

A technology of dihydroxyacetone and biocatalysis, applied in the direction of biochemical equipment and methods, methods based on microorganisms, microorganisms, etc., can solve problems such as limited and difficult to increase product yield, and achieve the effect of improving product yield

Inactive Publication Date: 2009-02-25
HUAQIAO UNIVERSITY
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Problems solved by technology

But when fermenting with microorganisms, the growth and survival of cells need to consume substrates, so that the product yield is difficult to improve, so that: (1) the theoretical yield of 1,3-PD with glycerol as carbon source is only 59.5%; ( 2) Using metabolic engineering bacteria to produce 1,3-PD, the highest level of product to glucose yield is 51%; (3) Using intestinal bacteria to anaerobically disproportionate glycerol to 1,3-PD The highest level is 55%
It can be seen that the potential for increasing the yield of 1,3-PD by microbial fermentation is very limited, how to further increase the yield of 1,3-PD is related to the competitiveness of industrial production of 1,3-PD by biological method

Method used

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  • Process for preparing 1,3-propylene glycol and dihydroxy acetone by bio-catalytic conversion of glycerol
  • Process for preparing 1,3-propylene glycol and dihydroxy acetone by bio-catalytic conversion of glycerol

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Embodiment Construction

[0019] Strain selection:

[0020] Several strains have been found that can ferment and produce 1,3-PD using glycerol as a substrate, but no natural bacteria that can use other organic substances as substrates to produce 1,3-PD have been found. So far, the strains capable of producing 1,3-PD mainly include Klebsiella pneumoniae, Klebsiella aerogenes, Enterobacter agglomerans, Citrobacter freundii and Lactobacillibrevis and Lactobacilli buchneri of the genera Lactobacillus, Clostridia butyricum and Clostridium pasteuri of the genera Clostridium ( Clostridia pasteuianum) and so on. Among them, K.pneumoniae, C.butyricum and C.freundii have higher 1,3-PD conversion rate and production capacity, and are the three most studied bacteria. C.butyricum has good tolerance to 1,3-PD, but it belongs to strict anaerobic bacteria, and its culture conditions are harsh. K.pneumoniae and C.butyricum belong to facultative anaerobic bacteria. Although they are pathogenic bacteria, the strains u...

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Abstract

The disclosed preparation method for 1, 3-propanediol and dihydroxyacetone comprises enzyme coupling catalysis and coenzyme regeneration, which increases product yield greatly.

Description

technical field [0001] The invention relates to a method for preparing 1,3-propanediol and dihydroxyacetone from biocatalyzed conversion of glycerin. Background technique [0002] 1,3-propanediol (1,3-propanediol, 1,3-PD) is an important chemical raw material, it can be directly used as antifreeze, various plasticizers, detergents, preservatives and emulsifiers for synthesis Raw material, it is also used in industries such as food, cosmetics and pharmaceuticals. Its main use is as a monomer for polymer materials such as polyester, polyether and polyurethane. Polyethylene terephthalate (PTT) synthesized with 1,3-PD as a monomer is compared with polyethylene terephthalate (polyethylene terephthalate, PTT) synthesized with ethylene glycol as a monomer PET) has many more excellent characteristics, such as: excellent resilience (the external force can be completely restored to its original shape after being elongated by 20%), dyeability (it does not need to be dyed with the hel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P7/18C12P7/26C12P39/00C12R1/225C12R1/22C12R1/07C12R1/01
Inventor 方柏山陈宏文
Owner HUAQIAO UNIVERSITY
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