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Reversal temperature sensitive injection type implantable drug supporter material

A carrier material and temperature-sensitive technology, which can be used in pharmaceutical formulations, medical preparations with non-active ingredients, and inorganic non-active ingredients, etc., which can solve the problem of aggravating the loss of salt due to the salting-out temperature and the inability to achieve long-term controllable drug delivery. , the problem of low mechanical strength of the gel drug store, to avoid surgical implantation and removal of preparations, good biocompatibility and biodegradability, and improve gelation speed and gel strength.

Inactive Publication Date: 2009-12-16
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the body environment, cellulose derivatives are easily swelled by solvation, thereby increasing the pores of the gel, intensifying the loss of salt that plays a role in salting out and lowering the gelling temperature, resulting in part or even all of the physical gel. Disintegration, low mechanical strength of the gel drug store and inability to be stable for a long time limit the application range of the system
Therefore, the "cellulose derivative-polyethylene glycol-salt" system in the prior art cannot achieve the purpose of long-term controllable drug administration

Method used

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  • Reversal temperature sensitive injection type implantable drug supporter material
  • Reversal temperature sensitive injection type implantable drug supporter material
  • Reversal temperature sensitive injection type implantable drug supporter material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The influence of the formulation of the gel material on the coagulation characteristics of the system:

[0027] 1. The effect of polysaccharide addition on the coagulation characteristics of "cellulose derivatives-polyethylene glycol-salt" reverse thermosensitive injection type drug carrier material.

[0028] The composition of the weight / volume ratio of the gel material components: methylcellulose is 1.5; gelatin is 0, 1, and 1.5 respectively; polyethylene glycol is 8; sodium chloride is 3.5. Adjust the pH of the above-mentioned sol solution to 7.4, divide it into 4 samples according to the polysaccharide content, and conduct 3 sets of parallel experiments for each sample. Detect the viscosity change with time of the hydrosol under low shear force at 37℃ with a digital display rotor viscometer, the shear rate is 1rpm, draw the system viscosity change curve with time, and characterize the in vitro coagulation characteristics of the system, such as figure 1 Shown. It can be...

Embodiment 2

[0036] The effect of the viscosity of polysaccharides on the gel strength of "cellulose derivatives-polyethylene glycol-salt" reverse thermosensitive injectable drug carrier materials.

[0037] The weight / volume ratio of the gel material components is hypromellose: 2; sodium alginate (low viscosity, medium viscosity, high viscosity): 1; polyethylene glycol: 8; sodium dihydrogen phosphate and hydrogen phosphate Equivalent mixture of sodium: 3.5.

[0038] The gel strength is characterized by the shear modulus G of the gel, in the cross-sectional area A 0 And height L 0 A certain pressure F is applied to the cylindrical gel spline, and the height L to which the sample is compressed is measured after 30s relaxation 1 . The stress-strain relationship can use the equation F / A 0 =-G(λ-λ -2 ) Characterization, where λ=L 1 / L 0 Is the deformation ratio (λ=1.0~0.7), so that the shear modulus G of the gel can be calculated.

[0039] Such as Figure 5 As shown, compared with the blank sample ...

Embodiment 3

[0041] The effect of polysaccharide addition on the drug release characteristics of "cellulose derivatives-polyethylene glycol-salt" reverse temperature-sensitive injectable drug carrier materials. 5-Fluorouracil, methotrexate, and glipizide were selected as model drugs.

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Abstract

The invention discloses a reverse temperature-sensitive injectable drug carrier material belonging to the field of medical materials. It is composed of cellulose derivatives, polyethylene glycol, polysaccharides and salts that have a salting-out effect on cellulose derivatives according to the weight / volume ratio of gel material components. In the present invention, by adding a certain concentration of polysaccharides to the "cellulose derivatives-polyethylene glycol-salt" system, the hydrophobic interaction between the macromolecules of the system is enhanced, the gelation speed of the system is accelerated, and the gelation rate is improved. Strength, reduces the degree of hydration and swelling, improves the stability of the gel, and slows down the release rate of the drug. The sol solution of this material can be injected at room temperature, has good biocompatibility and biodegradability, avoids surgical implantation and removal of preparations, and can be used as a subcutaneous implant, biological tissue repair skeleton, vagina, eye, traumatic brain injury Drug delivery vector for therapy, nerve damage treatment.

Description

Technical field [0001] The invention belongs to the field of medical materials. To be precise, it is a reverse temperature sensitive injection type implantable drug carrier material. Background technique [0002] Implantable Drug Delivery Systems (Implantable Drug Delivery Systems, hereinafter referred to as IDDS) are a type of controlled release formulations that are surgically implanted into the body or subcutaneously, or punctured into the subcutaneously, and can achieve the purpose of long-term stable drug delivery. With the development of pharmaceutics and materials science, intelligent polymer materials that have a sudden change in solubility depending on changes in external conditions such as temperature, pH, ionic strength, electric field, and magnetic field, especially those that are injectable, have good biocompatibility, Materials that are biodegradable in the body have been widely used in IDDS because they avoid surgery during the entire process of drug delivery and g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/38A61K47/02
Inventor 林莹朱德权昝佳蒋国强丁富新
Owner TSINGHUA UNIV