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Method for producing stabhyose, and method for producing stabhyose and catalpol by using rehmannia root

A production method and a technique for stachyose are applied in the production of stachyose, in the production field of stachyose and catalpol, and can solve the problem that it is difficult to ensure the effective substance content of stachyose products, product solubility and color deterioration, etc. To reduce the extraction time, avoid the deterioration of the sugar solution, and reduce the dosage

Active Publication Date: 2007-07-25
GUANGDONG APOLLO GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Extracting stachyose from plants is the main production source of stachyose. Many of the current production processes for producing stachyose from traditional Chinese medicine often involve high-temperature extraction and high-temperature concentration. High temperature can easily damage the quality of stachyose products. Lead to poor product solubility and color; and some of the purification process of plant extracts need to add chemical precipitants (such as flocculants) or adsorbents (such as activated carbon) to remove impurities and decolorize, these methods will not only introduce new Chemical impurities, and because the process needs to use heating to further affect the color and purity of stachyose products; in addition, some purification processes only use simple membrane filtration and single column chromatography for separation and purification, and it is difficult to ensure water Active substance content of threose sugar products
So far, there is no continuous system, which can be controlled at room temperature and can realize large-scale automatic production of high-quality stachyose production process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1, weigh 3Kg slices of dried raw rehmanniae, put them in a microwave oven, add 30L of pure water, treat at low temperature (30-50°C) for 30 minutes, coarsely filter with a filter cloth, and wash. repeat three times. The combined filtrate and washings were 110L in total. Then, filter and wash with a plate and frame filter press. Combine the filtrate and lotion, filter through a 0.3 μm microfiltration membrane, and then ultrafilter and wash with a 20,000 Da ultrafiltration membrane. The retentate was discarded. The ultrafiltration permeate is nanofiltered by 80 Da nanofiltration membrane. The nanofiltration permeate is used for the next extraction. The intercepted liquid of nanofiltration is injected into the column chromatography system composed of granular activated carbon column → SD300 macroporous adsorption resin column → D001-FD cation exchange resin column → D354-FD anion exchange resin column in series from the column port of granular activated carbon ...

Embodiment 2

[0023]Example 2, weighing fresh rehmannia, cut into 10Kg slices, squeezed, added 80L of pure water, soaked at room temperature for 5 hours, coarsely filtered with a filter cloth, and washed. repeat three times. Combine the filtrate and washings to a total of 300L. Then, filter and wash with a plate and frame filter press. Combine the filtrate and lotion, filter through a 0.5 μm microfiltration membrane, and then ultrafilter and wash through a 50,000 Da ultrafiltration membrane. The retentate was discarded. The ultrafiltration permeate is subjected to nanofiltration with a 150 Da nanofiltration membrane. The nanofiltration permeate is used for the next extraction. The intercepted liquid of nanofiltration is injected into the column chromatography system composed of granular activated carbon column → SD300 macroporous adsorption resin column → D001-FD cation exchange resin column → D354-FD anion exchange resin column in series from the column port of granular activated carbo...

Embodiment 3

[0025] Example 3, weigh 10Kg of dried raw rehmannia and cut into a microwave oven, add 100L of pure water, treat at low temperature (30-50° C.) for 30 minutes, coarsely filter with a filter cloth, and wash. repeat three times. The combined filtrate and washings were 400L in total. Then, filter and wash with a plate and frame filter press. Combine the filtrate and lotion, filter through a 0.3 μm microfiltration membrane, and then ultrafilter and wash with a 20,000 Da ultrafiltration membrane. The retentate was discarded. The ultrafiltration permeate is nanofiltered by 80 Da nanofiltration membrane. The nanofiltration permeate is used for the next extraction. The intercepted liquid of nanofiltration is injected into the column chromatography system composed of granular activated carbon column → SD300 macroporous adsorption resin column → D001-FD cation exchange resin column → D354-FD anion exchange resin column in series from the column port of granular activated carbon colu...

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Abstract

This invention provides a method for separating and extracting high-purity stachyose product from Rehmannia glutinosa and Stachys sieboldii. This invention also provides a method for continuously separating and extracting stachyose and catalpol from Rehmannia glutinosa. The method comprises: separating and purifying the extract by passing through continuous pressure-filtration, microfiltration, ultrafine filtration and nanofiltration membranes, and active carbon column, macroporous adsorption resin column, cation exchange resin column, and anion exchange resin column chromatography to obtain stachyose and catalpol. The method has scuh advantages as increased product quality, low wnwegy consumption, and increased raw material utility.

Description

technical field [0001] The invention relates to a production method for extracting and separating bioactive substances from plants, in particular to a production method for stachyose, and a production method for stachyose and catalpol. Background technique [0002] Stachyose is a functional oligosaccharide that exists in nature. It is not digested by the human body and can be used by bifidobacteria in the intestinal tract. It is an excellent growth factor for bifidobacteria. Stachyose can rapidly improve the internal environment of the human digestive tract, promote the formation of beneficial bacteria in the digestive tract, control the production of gas, acid and spoilage bacteria, and inhibit the production and absorption of endogenous carcinogens. Stachyose is low in sweetness and low in calories, suitable for diabetic patients. It can stabilize blood sugar, prevent constipation, and enhance immune function. Extracting stachyose from plants is the main production source...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/06C07H3/06C07H17/04A61K36/804
CPCY02P20/10
Inventor 刘钢单京瑞邓国江
Owner GUANGDONG APOLLO GRP
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