Polyurethane material for improving adhering growing of cells and rombolytic function

A polyurethane material and cell adhesion technology, which is applied in the fields of biomedical materials and polymer chemistry, can solve problems such as low cost, and achieve the effects of low cost, good cell compatibility, and easy control

Inactive Publication Date: 2007-09-12
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: based on the above research, provide a modified polyurethane material, which has good cell compatibility, can effectively promote the adhesion and growth of human cells, and has good blood compatibility , can effectively dissolve the thrombus formed on the surface of the material, so it can be used as a biomedical material for artificial blood vessel materials, artificial organs and devices implanted in the human body, and has a wide range of uses; at the same time, the preparation method of the material is relatively simple, easy to control, and the cost is relatively low. low

Method used

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  • Polyurethane material for improving adhering growing of cells and rombolytic function
  • Polyurethane material for improving adhering growing of cells and rombolytic function
  • Polyurethane material for improving adhering growing of cells and rombolytic function

Examples

Experimental program
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Effect test

Embodiment 1

[0042] First, dissolve the purified granular commercial polyurethane material (product of Shanghai Pengbosheng Polyurethane Co., Ltd.) in N, N-dimethylformamide (DMF), pour it into a flat-bottomed mold, and vacuum dry it after the solvent evaporates. To obtain the PU film, cut the PU film into small pieces with a diameter of 10 mm and a thickness of 0.5 mm, put it into a toluene solution of 5% MDI by mass ratio, stir and heat to 50 ° C, and then pass through N 2 Protection, triethylamine (TEA) according to mass ratio M TEA / M Toluene =2.5% was added to the reaction system, and the reaction was started after mixing evenly. After 60 minutes, the PU film was washed 4 times with toluene. Then put the above-mentioned functionalized PU film into a toluene solution with a mass ratio of 10% polyethylene glycol, heat to 40° C. for reaction under stirring, wash twice with distilled water after 24 hours, and then vacuum dry for 24 hours. Take out the dried PU film, put it into the acet...

Embodiment 2

[0044] Add a magnet in the there-necked flask, weigh 5 grams of polytetrahydrofuran ether glycol (molecular weight is 1000), 5 grams of toluene, and measure 25 mL of DMF, then heat it to 110 ° C with a constant temperature magnetic stirrer and keep it warm for 1 hour. Parts were removed as a toluene azeotrope. Then, its temperature was controlled at 60° C., and then the weighed 4.0 g of MDI and the measured 25 mL of DMF mixed solution were added into the reaction three-necked flask, and the temperature was controlled at this temperature range for 1.5 hours. Then slowly add 0.9 g of chain extender 1,4-butanediol into the three-necked flask with a dropper, raise the temperature to 80° C., and react for 3.5 hours under temperature control. Then pour the reaction solution in the three-neck bottle into the prepared large beaker filled with distilled water along the glass rod, and stir rapidly while pouring to obtain a white viscous product, which is polyurethane. Take it out and pu...

Embodiment 3

[0047] First, the purified granular commercial polyurethane material (product of Shanghai Pengbosheng Polyurethane Co., Ltd.) is dissolved in DMF, poured into a flat-bottomed mold, and then vacuum-dried after the solvent evaporates to obtain a PU film. The PU film is cut into a diameter of 10mm thick small piece of 0.5mm, put into the toluene solution of MDI with a mass ratio of 6%, stir and heat to 40 ℃, pass through N 2 Protection, the TEA according to the mass ratio M TEA / M Toluene =2.5% was added to the reaction system, and the reaction was started after mixing evenly. After 120 minutes, the PU film was washed 4 times with toluene. Then put the above-mentioned functionalized membrane into a toluene solution with a mass ratio of 20% polyethylene glycol, heat to 45° C. for reaction under stirring, wash with distilled water three times after 16 hours, and then vacuum-dry for 24 hours. Take out the dried PU film, put it into the acetonitrile solution with a mass ratio of 3%...

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Abstract

The polyurethane material possessing cell adhesion growth promoting and thrombolytic functions consists of one base layer of polyurethane material, and one modifying layer with possessing PEG space group connected via covalent bond to the polyurethane material in the base layer and two kinds of bioactive matters, RGD polypeptide and lysine, introduced simultaneously via surface grafting with NHS linked to The PEG space group. It is prepared through: functionating polyurethane material with MDI, surface grafting PEG, introducing active NHS group, grafting RGD polypeptide and lysine, and deprotecting epsilon-NH2 of lysine. The polyurethane material possesses excellent cell adhesion growth promoting function, thrombolytic function, effectively improved blood compatibility and cell compatibility, simple preparation process and low cost, and may be used as biomedicine material.

Description

technical field [0001] The invention relates to the fields of biomedical materials and macromolecule chemistry, in particular to a polyurethane material capable of promoting cell adhesion growth and thrombolytic function, as well as its preparation and application. Background technique [0002] Polyurethane (PU) materials have excellent wear resistance, flex resistance, soft touch, moisture resistance and resistance to various chemicals, and are easy to process and can be sterilized by conventional methods. Therefore, they are used in various medical environments, especially in It has great application value in the manufacture of various devices implanted in the human body, such as artificial heart valves and artificial blood vessels. However, the hemocompatibility of traditional polyurethane materials has not been completely resolved, thus restricting its clinical application. In addition, if the polyurethane material can have good cell compatibility at the same time, it c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J29/06B01J27/18B01J31/06
Inventor 陈红王亮王艺峰袁琳
Owner WUHAN UNIV OF TECH
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