Method for separating and purifying 10-deacetyl Baccatins III

A technology for removing acetylation and ethyl acetate, which is applied in the field of separation and purification of 10-deacetylbaccatin III combined with forward and reverse phase liquid chromatography technology, can solve the problems of incomplete separation of impurities, small processing capacity, and high cost, and achieve The solvent is easy to recycle and cheap, prolongs the service life, and has the effect of low cost
CN101045718AActive Publication Date: 2007-10-03北京信汇科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
北京信汇科技有限公司
Publication Date
2007-10-03

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Abstract

This invention relates to a kind of separation and purification method of 10- DABIII. This invention adopts positive and negative phase chromatographic technique combinding, takes normal phase color spectrum as first order hand ling, remove most impurity, in favor of protecting high cost reversion phase chromatography support, prolong its service life; whereas reversion phase chromatography could hand larger sample quantity, and has better removal effect to the impurity that normal phase colour spectrum unease separate off, solvent is easy reclaim and cost is cheaper. So the combinding of positive and negative phase chromatographic technique not only could obtain 10 -DABIII, but also be able to reduce cost. Besides, this invention also adopts two-stage color spectrum tand em isolation techniques, through pretreatment post to separate a part of impurity, then cascaded separating column to carry out subdivision, advance separating effect, increase load sample quantity of chromatographic column.
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Description

technical field

[0001] The invention relates to a method for separating and purifying 10-deacetylbaccatin III, in particular to a method for separating and purifying 10-deacetylbaccatin III in combination with forward and reverse phase liquid chromatography techniques. Background technique

[0002] The molecular structural formula of 10-deacetylbaccatin III (10-Deacetylbaccatin III, hereinafter referred to as 10-DABIII) is as follows:

[0003]

[0004] 10-DABIII is the main raw material for the synthesis of anticancer drug docetaxel and semi-synthetic paclitaxel. It mainly exists in the branches, leaves, bark and roots of Taxus chinensis. With the confirmation of the unique curative effect of taxane-based anticancer drugs, the market demand for such drugs is increasing day by day, which urgently requires more economical and reasonable utilization of existing taxus plants, as much as possible and efficiently from Separation and purification of the substances required for ...

Claims

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