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Surface fixed taurine ligand porous membrane material, preparation method and its application in blood fat adsorption separating

A surface-fixed, porous membrane technology, applied in semi-permeable membrane separation, chemical instruments and methods, blood filtration, etc., to achieve the effects of easy control of process conditions, good production repeatability, and simple preparation methods

Inactive Publication Date: 2007-10-24
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, the above-mentioned preparation process requires the use of organic solvents such as dimethyl sulfoxide, and whether there are toxic organic solvents in the prepared gel carrier remains to be further clinically examined.

Method used

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  • Surface fixed taurine ligand porous membrane material, preparation method and its application in blood fat adsorption separating
  • Surface fixed taurine ligand porous membrane material, preparation method and its application in blood fat adsorption separating
  • Surface fixed taurine ligand porous membrane material, preparation method and its application in blood fat adsorption separating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0092] Cut the medical polypropylene non-woven fabric with an average pore size of 0.10 μm into 5cm×5cm 2 The samples were ultrasonically cleaned in acetone and water for 15 to 30 minutes, and dried in vacuum for later use. Then, soak the above-mentioned sample in an aqueous solution containing 10% (mass percentage) of acrylic acid monomer, which additionally contains 1.0wt% ferrous sulfate polymerization inhibitor and 0.5wt% sulfuric acid catalyst. After soaking for 24 hours, place the sample At 60 In the radiation field of Coγ-ray source, the total cumulative irradiation dose is controlled to 30KGy. After the above-mentioned irradiation treatment sample was taken out, it was washed, dried, weighed and calculated to obtain a copolymerization grafting rate of acrylic acid of 30 wt%, and the corresponding surface carboxyl group content of the obtained porous membrane carrier material was 25 μmol / cm 2 , ATR-FITR infrared spectrum analysis found that the sample was at 1700cm -...

Embodiment 2

[0094] Cut the 0.45μm medical polypropylene non-woven fabric into 5cm×5cm 2 The samples were ultrasonically cleaned in acetone and water for 15 to 30 minutes, and dried in vacuum for later use. The above samples were then soaked in an aqueous solution containing 15% acrylic acid monomer. Contain the ferrous sulfate polymerization inhibitor of 0.5wt% in the solution, the sulfuric acid catalyst of 1.0wt% simultaneously, after soaking for 24 hours, the sample is placed in 60 In the Coγ-ray source radiation field, the total cumulative irradiation dose is controlled to be 20KGy. After taking out the above-mentioned radiation treatment sample, wash, dry, weigh and calculate the copolymerization grafting rate of acrylic acid to be 84wt%, quantitative titration surface carboxyl content is 70μmol / cm 2 . ATR-FITR infrared spectrum analysis found that at 1700cm -1 A strong absorption peak appears at , corresponding to the characteristic absorption signal of the carboxyl group, indica...

Embodiment 3

[0096] Cut the 1.0μm medical polypropylene non-woven fabric into 5cm×5cm 2 The samples were ultrasonically cleaned in acetone and water for 15 to 30 minutes, and dried in vacuum for later use. The above sample was then soaked in an aqueous solution containing 15% by weight of acrylic acid monomer. Contain the ferrous sulfate polymerization inhibitor of 0.5wt% in the solution, the sulfuric acid catalyst of 0.5wt% simultaneously, after soaking 24 hours, the sample is placed in 60 In the Coγ-ray source radiation field, the total cumulative irradiation dose is controlled to be 30KGy. After taking out the above-mentioned irradiation treatment sample, wash, dry, weigh and calculate the copolymerization grafting rate of acrylic acid to be 75wt%, quantitative titration surface carboxyl content is 96μmol / cm 2 . ATR-FITR infrared spectrum analysis found that at 1700cm -1 A strong absorption peak appears at , corresponding to the characteristic absorption signal of the carboxyl group...

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Abstract

It is aimed to provide a porous carrier surface fixed with taurine absorbed sulfo group. Its average hole radius is made by 0. 05-100mum medical polymer nonwoven cloth modified by 60Cogammacoradiated the polyacrylic acid surface together with porous film, with the help of one aminopropancdiol, 3 EDC activated carboxy group coupling with biologically compatible taurine absorbed sulfo group with the surface fixed with porous film carrier material reinforcing selective absorption and separation effect. It is simple, safe and effective. The material is compatible with blood, with excellent use in plasma absorption separation, clinical blood dynamic purification and waste plasma regeneration and utilization.

Description

technical field [0001] The invention provides a novel surface-fixed polymer porous membrane carrier material of taurine adsorption ligand, a preparation method and its application in plasma lipid component adsorption and separation. The polymer porous membrane material provided by the invention relates to the selective adsorption and separation carrier medium material of plasma lipid components in the blood purification and perfusion treatment application of patients with clinical hyperlipidemia, and belongs to the field of biomedical materials and medical device auxiliary materials. The invention involves a new type of polymer porous membrane carrier material with immobilized taurine adsorption ligands on the surface, which is prepared from medical grade polymer non-woven fabrics with different average pore sizes. 60 Coγ-ray co-irradiation graft copolymerization acrylic acid modification and subsequent surface coupling immobilization of taurine adsorption functional ligands a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/10B01D71/82B01D67/00B01J20/22A61M1/34A61M1/36
Inventor 曹阿民侯小东张涛
Owner SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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