Oral insulin compound medicine preparation and its preparing method

Abstract

The invention discloses an oral insulin complexing preparation, which is characterized by the following: allocating 1-15% insulin raw material, 50-97% stable protecting agent, 1-15% carrying medicine carrier, 1-20% absorption promoting agent; setting the stable protecting agent as one or several of carbowax and casein, protamine, albumin and protease inhibitor; setting the carrying medicine carrier as calcium phosphate salt; setting the absorption promoting agent as one or several of salicylic acid, cholate and fatty acid; setting the insulin raw material as human retooling insulin or human retooling insulin chemical trimmed by single methoxy carbowax derivant. This invention also relates to a preparing method of oral insulin complexing preparation. This invention can increase biostability of human retooling insulin and can resist degradation of gastrointestinal tract enzyme.

Description

technical field

[0001] The invention belongs to the field of medicine, and more specifically relates to an oral insulin compound preparation and a preparation method thereof. Background technique

[0002] Diabetes is a common chronic disease that threatens human beings. There are currently 130 million diabetic patients in the world. With the enrichment of material life and the reduction of physical activity, the number of people with diabetes is increasing year by year. The incidence of diabetes has increased from 1% more than ten years ago to 2.5% at present. Various complications of diabetes, such as cardiovascular, kidney, fundus and nerve lesions, are the main factors causing loss of labor, disability and death of patients, and its mortality rate has also risen to the third place after cardiovascular disease and cancer.

[0003] Insulin is the drug of choice for the treatment of diabetes. Since insulin is a protein polypeptide substance, it is easily degraded by prote...

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