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Chitose/polyglycol blending medicine film and its preparing method as well as purpose

A technology of polyethylene glycol and chitosan, which is used in medical science, absorbent pads, bandages, etc., can solve the problems of unsatisfactory comprehensive performance of pure chitosan, achieve excellent drug release performance, wide application prospects, and improved performance. Effect

Inactive Publication Date: 2008-04-09
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the overall performance of pure chitosan is not ideal, and it cannot meet the requirements in some fields.

Method used

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  • Chitose/polyglycol blending medicine film and its preparing method as well as purpose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Embodiment 1: get 4g deacetylation degree and be 87%, viscosity-average molecular weight is 8.5 * 10 5 Chitosan is dissolved in the acetic acid solution of 100ml2% (mass ratio) to obtain chitosan solution; Get 0.15g viscosity-average molecular weight and be 6000, analytically pure polyethylene glycol is dissolved in 4ml distilled water to obtain polyethylene glycol solution. Fully mix the above two solutions with 0.4g ciprofloxacin hydrochloride, filter, degass under reduced pressure, use 1% to 3% (mass ratio) sodium tripolyphosphate aqueous solution as the coagulation solution, evaporate at room temperature by salivation Preparation of chitosan / polyethylene glycol blended drug-loaded film. Its mechanical properties and release properties are listed in Table 1.

Embodiment 2

[0011] Embodiment 2: Get 4g chitosan and dissolve in the acetic acid solution of 100ml 2% (mass ratio) to obtain chitosan solution; Get 0.3g polyethylene glycol and dissolve in 8ml distilled water to obtain polyethylene glycol solution. Fully mix the above two solutions with 0.4g ciprofloxacin hydrochloride, filter, degass under reduced pressure, use 1% to 3% (mass ratio) sodium tripolyphosphate aqueous solution as the coagulation solution, evaporate at room temperature by salivation Preparation of chitosan / polyethylene glycol blended drug-loaded film. Its mechanical properties and release properties are listed in Table 1.

Embodiment 3

[0012] Embodiment 3: Get 4g chitosan and dissolve in the acetic acid solution of 100ml 2% (mass ratio) to obtain chitosan solution; Get 0.6g polyethylene glycol and dissolve in 15ml distilled water to obtain polyethylene glycol solution. Fully mix the above two solutions with 0.4g ciprofloxacin hydrochloride, filter, degass under reduced pressure, use 1% to 3% (mass ratio) sodium tripolyphosphate aqueous solution as the coagulation solution, evaporate at room temperature by salivation Preparation of chitosan / polyethylene glycol blended drug-loaded film. Its mechanical properties and release properties are listed in Table 1.

[0013] The salivation evaporation method used in the above embodiments is a prior art, which has been described in detail in the existing literature, so the salivation evaporation method will not be repeated in each embodiment.

[0014] Table 1

[0015]

[0016] As can be seen from the data in Table 1, the chitosan / starch blended drug-loaded film pro...

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Abstract

The invention discloses a chitosan / polyethylene glycol blend drug-loaded film with fine performance, as well as the preparation method thereof and the purpose. The drug-loaded film takes chitosan, polyethylene glycol and ciprofloxacin hydrochloride as raw materials, and is formed by mixing the chitosan, the polyethylene glycol and the ciprofloxacin hydrochloride; the mass percent content of the polyethylene glycol in the blend drug-loaded film is 2 percent to 10 percent, the mass percent content of the ciprofloxacin hydrochloride is 3 percent to 15 percent, and the mass percent content of the chitosan is 80 percent to 95 percent. The preparation steps are as follows: the chitosan is dissolved in acetate solution with 1 percent to 2 percent of mass percent to obtain chitosan solution with 3 percent to 6 percent of mass percent, the polyethylene glycol is dissolved in distilled water to obtain polyethylene glycol solution with 3 percent to 6 percent of mass percent, according to the proportion with the mass ratio of chitosan: polyethylene glycol: ciprofloxacin hydrochloride being 8.3 to 9.5: 0.2 to 1: 0.3 to 1.5, the chitosan solution and the polyethylene glycol solution are evenly mixed with ciprofloxacin hydrochloride, after being filtered, decompressed and debubbled, the mixed solution is added with coagulation solution, and then the chitosan / polyethylene glycol blend drug-loaded film is prepared through the salivating evaporation method under the room temperature. The drug-loaded film can be widely applied to the fields such as medicine and food, etc., and is especially suitable for being used as a drug film for the wound dressing and the vivo release.

Description

technical field [0001] The invention relates to a chitosan / polyethylene glycol blend drug-loading film for making dressings and drug carriers, a preparation method and application thereof, and belongs to the field of polymer materials. Background technique [0002] Chitosan is the second largest biological polysaccharide next to cellulose in nature, and it is also the only alkaline polysaccharide that exists in large quantities in nature. It has good biocompatibility, biodegradability, and excellent properties such as antibacterial, antiseptic, hemostasis and promotion of wound healing. In addition, the weak acid solution of chitosan is positively charged, so it can interact with negatively charged polymers such as DNA, antigens and most protein drugs, and is widely used in drug carriers and medical auxiliary materials. However, the overall performance of pure chitosan is not ideal, and it cannot meet the requirements in some fields. Contents of the invention [0003] Th...

Claims

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Application Information

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IPC IPC(8): A61L15/44A61L15/28
Inventor 杜予民王群董战峰
Owner WUHAN UNIV
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