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Pharmaceutical composition of red sage root and cattail pollen

A technology of composition and medicine, applied in the field of medicine

Inactive Publication Date: 2008-04-16
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, using the interaction between Danshen or Danshen extract and Puhuang or Puhuang extract to make compatible prescriptions to prepare drugs for treating cardiovascular and cerebrovascular diseases has not yet been reported.

Method used

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  • Pharmaceutical composition of red sage root and cattail pollen
  • Pharmaceutical composition of red sage root and cattail pollen
  • Pharmaceutical composition of red sage root and cattail pollen

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0153] Example 1 Salvia miltiorrhiza extract extraction process and preparation

[0154] Preparation of Danshen Extract

[0155] Take Danshen medicinal material, crush it into coarse powder, add water to decoct twice, add 12 times of water for the first time, add 10 times of water for the first time, each time for 2 hours, combine the decoction, filter, and concentrate the filtrate to relative density under reduced pressure 1.10~1.15 (60°C) concentrated solution, add ethanol until the alcohol content reaches 85%, refrigerate for 24 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, add hydrochloric acid to adjust the pH value to 2, shake with ethyl acetate Extracted 3 times, combined ethyl acetate solution, and evaporated to dryness. The residue was dissolved in acidic water with a pH value of 2, added to the treated polyamide column, first eluted with 2 times the column volume of water, discarded the water washing solution, and then eluted ...

Embodiment 2

[0169] Example 2 Extraction process and preparation of Puhuang extract

[0170] Preparation of Puhuang Extract

[0171] Take the medicinal material of Puhuang, add 70% ethanol to extract three times, and extract for 3 hours each time. Add alcohol 14 times the amount for the first and second times, add alcohol 10 times the amount for the third time. Combine the extracts, filter, recover the ethanol from the filtrate to a concentrated solution with a relative density of 1.04-1.06 (50°C), add an equal amount of water to dilute, mix well, refrigerate at 4°C for 24 hours, centrifuge, take the supernatant, and use an equal amount of Shake and extract petroleum ether for 2 times, discard the petroleum ether liquid, shake and extract the water liquid with an equal amount of water-saturated n-butanol for 3 times, combine the n-butanol extracts, concentrate to dryness, add a small amount of water to dissolve the residue, and go to AB -8 macroporous resin columns, eluting with water,...

Embodiment 3

[0182] The preparation of embodiment 3 Danpu composition tablet

[0183] Prescription one:

[0184] Salvia miltiorrhiza extract 17g is equivalent to 1kg of raw medicinal materials

[0185] Puhuang extract 32g is equivalent to 1kg of raw medicinal materials

[0186] 100g pregelatinized starch

[0187] Microcrystalline Cellulose 30g

[0188] Low-substituted hydroxypropyl cellulose 30g

[0189] 2% HPMC aqueous solution appropriate amount

[0190] Magnesium Stearate 4g

[0191] Carboxymethyl starch sodium 8g

[0192]

[0193] A total of 1000 tablets were prepared

[0194] Prescription two:

[0195] Salvia miltiorrhiza extract 17g is equivalent to 1kg of raw medicinal materials

[0196] Puhuang extract 63g is equivalent to 2kg of raw medicinal materials

[0197] 110g pregelatinized starch

[0198] Microcrystalline Cellulose 35g

[0199] Low-substituted hydroxypropyl cellulose 35g

[0200] 2% HPMC aqueous solution appropriate...

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Abstract

The present invention relates to medical technique field, to provide a medicinal composition for treating cardiovascular and cerebrovascular diseases, its preparation method and preparation containing the medicinal composition, constitution of the raw materials used for preparing the medicinal composition containing the effective components are red sage root or red sage root extraction and cattail pollen or cattail pollen extraction. The medicinal composition can be prepared into clinic or pharmaceutical acceptable preparations, optimizing oral preparation or injection. Mainly used for preparing medicine for treating cardiovascular and cerebrovascular diseases such as coronary heart disease, angina pectoris, myocardial infarction, blood stasis type pulmonary heart disease, ischemic encephalopathy, cerebral thrombus, hypertension, hyperlipemia and etc. The medicinal composition of the present invention has synergistic interaction, effect is increased greatly than using single red sage root or red sage root extraction and single cattail pollen or cattail pollen extraction, low toxicity, high safety, and good stability.

Description

[technical field] [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition of Danshen or Danshen extract and Puhuang or Puhuang extract, a preparation method thereof, an application in preparing medicine for treating cardiovascular and cerebrovascular diseases, and a preparation containing the pharmaceutical composition . [Background technique] [0002] Cardiovascular and cerebrovascular diseases have always been the enemy that threatens human health, killing 12 million people every year, nearly 1 / 4 of the total population death. As our country gradually enters the elderly society, and with the development of economy and the change of lifestyle and eating habits, the prevalence and mortality of cardiovascular and cerebrovascular diseases are increasing year by year. According to the forecast of the World Health Organization, by 2020, non-communicable Diseases will account for 79% of the causes of death in my country, and ca...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P9/10A61P9/12A61P3/06
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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