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Multiple efficacy complex microsphere for cosmetics and preparation method thereof

A porous composite microsphere and composite microsphere technology, applied in the field of inorganic/polymer porous composite microsphere and its preparation, can solve the problems of easy clogging of pores and high slow-release effect, and achieve the goal of reducing production cost and good wettability Effect

Inactive Publication Date: 2010-10-27
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to solve the deficiencies in the existing cosmetic formulation adding system technology, and provide a composite particle loaded with various functional cosmetic ingredients and its preparation method
The multi-functional cosmetic composite microspheres prepared by the method can solve the problems of the aggregation of inorganic nano-functional particles and easy clogging of pores, and can load a variety of cosmetic active substances, and the slow-release and controlled-release time can reach 8-10 hours. The substance has a photoprotective function, and its slow-release effect is more than 3 times higher than that of a simple porous polymer slow-release system

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] In the first step, 4g of azobisisobutyronitrile is dissolved in a mixed solvent of ethanol and water. The above solution was transferred into a 250mL four-necked flask, and then 40g of styrene, 40g of methacrylic acid, and 20g of toluene were added under nitrogen atmosphere and high-speed stirring. Carry out the polymerization reaction in a constant temperature water bath at 70°C for 12 hours, end the reaction, filter the reactant and wash it with ethanol and deionized water several times, extract it with toluene in a Soxhlet extractor for 12 hours, filter, methanol, ethanol, deionized water After washing with water several times, vacuum drying at room temperature for 24 hours, the porous polymer microspheres with an average particle diameter of 20um, an average pore diameter of 49.6nm and a porosity of 15% were obtained, which were stored for future use.

[0032] In the second step, 10 g of titanium dioxide nanoparticles and 100 g of ethanol were added to the reactor, ...

Embodiment 2

[0037] In the first step, take 1g of polystyrene seed microspheres and disperse them in a solution of 100g of water and ethanol; 20g of styrene, 20g of methyl methacrylate, 10g of toluene, 1g of benzoyl peroxide, and 1g of sodium benzenesulfonate Disperse in a solution of 200g of water and ethanol; mix the above two solutions, stir at room temperature for 12 hours, heat up to 70°C, polymerize for 12 hours, end the reaction, filter the reactant and wash it with ethanol and deionized water for more Once, in a Soxhlet extractor, extract with toluene for 18 hours, filter, wash with methanol, ethanol, and deionized water several times, and vacuum-dry for 12 hours at room temperature to obtain an average particle size of 10um, an average pore size of 40.2nm, and a porosity of 35% of the porous polymer microspheres were saved for future use.

[0038] In the second step, 6g of zinc dioxide nanoparticles and 80g of ethanol were added to the reactor, stirred at room temperature for 1 ho...

Embodiment 3

[0043] The first step is to take 1g polystyrene seed microspheres and disperse them in a solution of 100g water and ethanol; 10g styrene, 10g divinylbenzene, 5g maleic anhydride, 10g toluene, 0.3g benzoyl peroxide, Disperse 0.5g of sodium benzenesulfonate in a solution of 200g of water and ethanol; mix the above two solutions, stir at room temperature for 12 hours, heat up to 70°C, polymerize for 12 hours, and end the reaction. Filter the reactant and wash with ethanol , washed with deionized water several times, extracted with toluene for 24 hours in the Soxhlet extractor, filtered, washed with methanol, ethanol and deionized water several times, and vacuum-dried for 5 hours at room temperature to obtain an average particle size of 5um and an average pore size of 30.5nm, porous polymer with a porosity of 90%, save for future use.

[0044] In the second step, add 2g of pearl powder nanoparticles and 50g of ethanol into the reactor, stir under reflux at room temperature for 0.5...

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Abstract

The invention discloses a multi-effect composite microsphere for cosmetics and the preparation method thereof. The multi-effect composite microsphere for cosmetics takes polymer porous microsphere as parent particle and nano inorganic particles as core particles, wherein the core particles are evenly scattered and jointed on the surface of the parent particle to form porous inorganic / polymer composite microsphere. When in preparation, the polymer porous microsphere and solvent are prepared into suspension, then the nano inorganic particles which are processed by silane coupling agents are added in the suspension, and the temperature is constant at 30 to 100 DEG C, thus the inorganic / polymer porous composite microsphere is prepared by high-speed stirring and reflux. The invention solves the problems of clustering and pores clogging caused by the too fine particle size of the nano inorganic particles for cosmetics, at the same time, the porous structure has the cosmetic active matters which are loaded with different effects, so as to achieve the functions of multi-component coexistence, slow release and controlled release. Compared with the other sustained-release microspheres, the composite microsphere has photoprotective function to the cosmetic active matters which are easy to be photo-oxidized and are loaded in the interior, and the sustained-release performance can be improved by more than three times.

Description

technical field [0001] The invention relates to a novel loading system for cosmetics, specifically an inorganic / polymer porous composite microsphere (particle) capable of simultaneously loading cosmetic nano-inorganic particles and various skin care active ingredients and a preparation method thereof. Background technique [0002] In the face of intense market competition and strong consumer demand for high-efficiency, multi-functional personal care products, traditional design and manufacturing technologies can no longer meet the needs of high-end cosmetic formulations. The cosmetic activity that can be added by using existing formulation design technologies The content and types of components are also extremely limited. Among all kinds of high-end cosmetics, most of them need to have several or more functions: anti-aging, freckle removal, acne removal, sun protection, anti-UV, whitening, heat preservation, etc. In order to have several functions in a certain cosmetic at t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/02A61K8/25A61K8/27A61K8/29A61K8/84A61K8/98A61Q19/00
Inventor 李森程江韦宝卿皮丕辉文秀芳杨卓如李志英
Owner SOUTH CHINA UNIV OF TECH
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