Dropping pills containing ursolic acid and method for preparing the same

Abstract

The invention provides a medicament which has the functions of antineoplastic, oxidation resistance, anti viral hepatitis and antiphlogistic. The invention particularly relates to a dripping pill which contains ursone and a process for preparation. The invention overcomes the shortcomings of the prior dripping pills that pure natural degrees of findings which are used by the prior dripping pills are not high, and chemosynthesis findings which are commonly used are not in food additives catalogs of some countries, and tastes of the dripping pills are worse. The invention is a pharmaceutical preparation whose natural degree is higher, safety is stronger, and side effect is lower.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a dripping pill containing ursolic acid and a preparation method thereof. Background technique [0002] Ursolic acid, also known as ursolic acid and ursolic acid, is widely distributed in nature and exists in a variety of plants. Ursolic acid is a pentacyclic triterpenoid compound with a molecular formula of C30H48O3 and a molecular weight of 456.68. Some Chinese herbal medicines containing ursolic acid have the effects of promoting blood circulation, dispelling blood stasis, relieving pain, strengthening the heart, reducing inflammation, and protecting the liver. Modern pharmacological studies have found that ursolic acid has a wide range of biological effects, especially its anti-tumor, anti-oxidation, anti-viral hepatitis, and anti-inflammation effects, which have increasingly attracted people's attention. Application number: 200310116883.4, application date: 2003.12.2, applicant: Be...

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Problems solved by technology

Application number: 200310116883.4, application date: 2003.12.2, applicant: Beijing Zhengda Pharmaceutical Technology Co., Ltd., name of invention: ursolic acid dripping pills and its preparation method The patent literature provides a drop pill preparation and its preparation method. The drop pill drug uses polyethylene glycol and other auxiliary materials to make ursolic acid into a drop pill; although the drop pill overcomes the defects of the current tablet and accelerates the dissolution rate, the drop pill has the defect that the natural degree of the auxiliary material used is not high

[0003] With the global expansion of the market and the requirement of human beings to return to nature, the use of drugs with low toxicity and side effects, especially pure natural drugs, has become the first choice of people. The dropping pill preparation is a new type of Chinese medicine preparation with high efficiency and quick effect. The shortcomings and deficiencies of traditional Chinese medicine preparations in the past, but the current drop pill preparations generally face the following problems: 1. The drop pill auxiliary materials are not purely natural: at present, most of the drop pill base auxiliary materials are chemically synthesized, and the natural degree is low. New alternatives The search for matrix excipients, especially the search for alternative matrix excipients with a high degree of naturalness and the determination of their preparation process, is also very difficult, because the preparation conditions required for common and possible substitutes for natural matrix excipients are very harsh. And its dripping pill dripping conditions are the key to affect the preparation of dripping pills

If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work

2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been successfully exported to many countries, but There are also many problems at present, because different countries have different approvals for the excipients selected for the preparation of Chinese medicine dripping pills, especially in Europe with developed industries, which have stricter regulations on food excipients and pharmaceutical excipients, and the drops exported as health food The chemically synthes

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