Medicine foe diabetes mellitus

A technology of medicine and raw materials, which is applied in the field of traditional Chinese medicine to achieve the effect of glycosylated hemoglobin and lowering blood sugar

Active Publication Date: 2008-06-25
GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the industry, it is generally recognized that the combination of syndrome differentiation and treatment combined with the application of hypoglycemic western medicine can effectively reduce blood sugar, but no single traditional Chinese medicine or traditional Chinese medicine compound has a single hypoglycemic effect that is generally recognized by everyone

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1, the preparation of the medicine for treating diabetes of the present invention

[0037] 1. The active ingredient of the drug and the dosage of the active ingredient of the drug

[0038] Bitter melon slices 30g Bitter ginseng 9g Coptidis 30g

[0039] Anemarrhena 30g Suanzaoren 15g Pao Jiang 6g

[0040] Red yeast rice 3g, tangerine peel 9g, rhubarb 2g

[0041] peach kernel 6g

[0042] Two, prepare the traditional Chinese medicine according to the pharmaceutical active ingredient and the dosage ratio of step one

[0043] 1. Put 140g of medicine into the medicine pot;

[0044] 2. Add 500ml of water (preferably without medicine), soak for 30-40 minutes;

[0045] 3. Decoct in medium heat and water for 30 minutes, take 200ml of juice, and make 30ml of extract.

Embodiment 2

[0046] Embodiment 2, the effect of Qingrejiangzhuo prescription of the present invention on the morphological changes of pancreas and liver in OLETF rats (spontaneous type 2 diabetic rats)

[0047] Forty OLETF rats (purchased from Tokushima Research Institute of Otsuka Pharmaceutical Co., Ltd., Japan) were fed with conventional diet for 32 weeks, and their body weight was >560 g. They were randomly divided into 4 groups, 10 rats in the diabetes model group, 10 rats in the western medicine group, and 10 rats in the traditional Chinese medicine group. There were 10 rats in the dosage group and 10 rats in the high-dose Chinese medicine group. Ten Wistar rats (purchased from the Experimental Animal Center, Chinese Academy of Medical Sciences) were used as normal controls.

[0048] Experiments were carried out with the medicine prepared in Example 1, which was diluted with distilled water to a solution with a concentration of 4 g crude drug / ml before gavage. Rats were administered...

Embodiment 3

[0077] Example 3, Experimental Research on the Mechanism of Qingrejiangzhuo Recipe of the Present Invention Improving the Insulin Resistance of Experimental STZ Diabetic Rat Model

[0078] 1) Preparation and administration of diabetes models

[0079] 50 male Wistar rats (purchased from the Experimental Animal Center of Chinese Academy of Medical Sciences), weighing 180-220 g, aged 6-8 weeks. Streptozotocin (STZ) (Sigma, batch number: 202-263-7) was prepared into a 1% solution in an ice bath with 0.1 mol / L citric acid buffer, pH 4.4. After fasting for 12 hours, 40 rats were randomly selected, and STZ was injected intraperitoneally in the left lower abdomen, 65 mg / kg body weight. Three days later, the blood glucose of the rats was measured, and those above 16.7mmol / L were determined to be diabetes mellitus, and 30 diabetic rats were selected and divided into a diabetes model group (10 rats), a Chinese medicine group (10 rats) and a Western medicine group (10 rats) . Ten rats ...

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PUM

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Abstract

The invention discloses a medicine for treating diabetes mellitus. The medicine is made by the following raw materials: balsam pear slices 30g, sophorae flavescentis radix 9g, coptis chinensis 30g, anemarrhenae rhizome 30g, spina date seed 15g, zingiberis rhizoma tostum 6g, monascus 3g, tangerine peel 9g, rhubarb 2g and persicae semen 6g. The invention achieves repeatable affirmation effect through the clinical test for treating 2-type diabetes mellitus by the heat clearing and cloud dropping method, which can improve a 2-type diabetes mellitus model rat abnormal glucose metabolism by means of the obvious improvement of insulin resistance and islet cell function. The invention has great significance on alleviating fatty liver and maintaining normal blood lipid.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating diabetes. Background technique [0002] Diabetes mellitus is a systemic disease mainly caused by the disorder of glucose metabolism caused by absolute or relative insufficiency of insulin in the body. In recent years, with the in-depth research on the pathogenesis of type 2 diabetes, especially some new experimental techniques such as cell potential measurement, targeted gene mutation, transgene synthesis, and the application of fluorescent proteins in the study of mammalian gene expression, pancreatic islet cells Self-insulin resistance (including β, α and δ cell insulin resistance) is gradually recognized by people. The latest research has confirmed that insulin receptors and their downstream signal transduction pathways also exist on islet cells; islet cells are not only insulin-secreting cells, but also target cells for insulin act...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/14A61K9/16A61K9/20A61K9/48A61P3/10
Inventor 仝小林
Owner GUANGZHOU BAIYUNSHAN ZHONGYI PHARMA COMPANY
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