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Magnetic inorganic nano-particle/ordered meso-porous silica core-shell microspheres and preparation thereof

A technology of mesoporous silica and amorphous silica, applied in the direction of fibrous fillers, etc., can solve the problems of poor magnetic response effect of composite materials, uneven shape and disorder of composite materials, etc.

Inactive Publication Date: 2008-06-25
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, there are few reports on the synthesis of core-shell composite nanospheres with magnetic oxide particles as the core and ordered mesoporous materials as the shell.
In the existing reports, the synthesized composite materials have disadvantages such as poor magnetic response effect, uneven shape of the composite material, and inability to disperse well in water.
In addition, the disordered or mesopores parallel to the surface of the microspheres in the synthesized materials have certain deficiencies in material transport.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] (1) Uniformly disperse 0.1g magnetic ferric ferric oxide particles with a size of about 300nm in 80ml ethanol, 20ml deionized water and 1ml concentrated ammonia water (28wt%), add 0.3g tetraethyl orthosilicate (TEOS), room temperature After stirring for 6 hours, a magnetic composite microsphere with a layer of silicon dioxide deposited on the surface was obtained. The product was separated by a magnet and washed with a mixed solution of ethanol and water. After washing, the product was dried at room temperature and then used.

[0017] (2) Ultrasonic disperse the magnetic Fe3O4 composite microspheres after depositing a layer of silicon dioxide on the surface in a solution containing 60ml ethanol, 80ml deionized water, 1.00g concentrated ammonia water and 0.30g cetyltrimethylammonium bromide (CTAB) mixed solution, after stirring for 0.5h to make the solution uniform, add 0.40g tetraethyl orthosilicate (TEOS) dropwise, and continue stirring for 6h after the dropwise additio...

Embodiment 2

[0020] (1) Uniformly disperse 0.1g magnetic iron ferric oxide particles with a size of about 500nm in 100ml ethanol, 10ml deionized water and 1ml concentrated ammonia water (28wt%), add 0.25g tetraethyl orthosilicate (TEOS), room temperature After stirring for 7 hours, the magnetic composite microspheres with a layer of silicon dioxide deposited on the surface were obtained. The product was separated by a magnet and washed with a mixed solution of ethanol and water. After washing, the product was dried at room temperature and then used.

[0021] (2) Ultrasonic disperse the magnetic Fe3O4 composite microspheres after depositing a layer of silicon dioxide on the surface in a solution containing 90ml ethanol, 60ml deionized water, 1.00g concentrated ammonia water and 0.30g cetyltrimethylammonium bromide (CTAB) mixed solution, after stirring for 0.8h to make the solution uniform, add 0.40g tetraethyl orthosilicate (TEOS) dropwise, and continue stirring for 5h after the dropwise add...

Embodiment 3

[0024] (1) 0.1g magnetic NiFe with a size of about 300nm 2 o 4The particles were evenly dispersed in 90ml of ethanol, 10ml of deionized water and 1ml of concentrated ammonia water (28wt%), added 0.5g of tetraethyl orthosilicate (TEOS), and stirred at room temperature for 10h to obtain a magnetic composite with a layer of silicon dioxide deposited on the surface. The microspheres are separated by a magnet and washed with a mixed solution of ethanol and water. After washing, the product is dried at room temperature for use.

[0025] (2) The magnetic NiFe after depositing a layer of silicon dioxide on the surface 2 o 4 The composite microspheres were ultrasonically dispersed in a solution containing 30ml ethanol, 110ml deionized water, 1.00g hydrochloric acid aqueous solution (1.0M) and 0.30g Brij 56 (C 16 h 33 EO 10 ) in the mixed solution, after stirring for 0.4h to make the solution uniform, add 0.40g orthomethyl orthosilicate (TEOS) dropwise, and continue stirring for 8h...

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PUM

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Abstract

The invention belongs to the nano-composite material technology field, in particular to a magnetic inorganic nano-particle / ordered mesoporous silica core-shell microsphere and a preparation method thereof. The invention first utilizes sol-gel chemical synthesis method, coats a layer of amorphous silica on the surface of a plurality of magnetic inorganic nano-particles, then utilizes self-assembly of an organic surfactant as structure-directing agent and inorganic species in the solution, coats a layer of ordered meso-structured silica / surfactant composite material on the surface of the magnetic inorganic nano-particle / silica composite microsphere, removes the surfactant through solvent extraction, and obtains the ordered mesoporous magnetic inorganic nano-particle / silica core-shell structure composite microsphere material. The composite microsphere has high specific surface area, strong magnetic responsiveness, and wide application prospect in bioseparation and bioabsorption. The invention is simple in method, easy in obtaining raw materials, and suitable for large scale production.

Description

technical field [0001] The invention belongs to the field of advanced nanocomposite materials and technology, and specifically relates to a magnetic inorganic nanoparticle / ordered mesoporous silica core-shell microsphere and a preparation method thereof. technical background [0002] In recent years, with the needs of people in biological analysis, separation, enzyme immobilization, and disease diagnosis, core-shell composite microspheres with magnetic iron oxide particles as the core and silica materials as the shell have attracted widespread attention. The reason is that this composite microsphere has magnetic response characteristics, can simplify and facilitate separation and analysis, has low toxicity to organisms, and can graft different functional groups on the surface of silica through chemical modification, thereby increasing its density. application field. [0003] Compared with traditional silica materials, ordered mesoporous silica materials have the characteris...

Claims

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Application Information

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IPC IPC(8): C09C1/22C09C1/24B22F1/02
Inventor 邓勇辉刘翀邓春晖赵东元
Owner FUDAN UNIV
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