Method for synthesizing lactic acid by using glycerol

A technology of glycerin and lactic acid, which is applied in chemical instruments and methods, preparation of organic compounds, preparation of carboxylate, etc., can solve problems such as equipment corrosion, high equipment requirements, harsh production equipment, etc. The effect of simple system and easy industrialization

Active Publication Date: 2008-07-23
PEKING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The problem that this method exists is: (1) needs to use a large amount of H in the reaction 2 As a reaction raw material, while H 2 It is a very important energy source, its source is limited, its cost is high, and it is not easy to store and transport; Avoi...

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  • Method for synthesizing lactic acid by using glycerol
  • Method for synthesizing lactic acid by using glycerol
  • Method for synthesizing lactic acid by using glycerol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1, glycerin oxidation directly synthesizes lactic acid

[0034] 2 g of glycerol (Glycerol A.R. Beijing Chemical Reagent Company) and 3.46 g of sodium hydroxide (Sodium hydroxide A.R. Beijing Beihua Fine Chemicals Co., Ltd.) were dissolved in 40 mL of water and transferred to a 100 mL three-neck round bottom flask. Add 0.13g Au / TiO 2 Catalyst (World Gold Council World Gold Council), the O 2 , heated to 90°C, and reacted for 3 hours. The experiment was repeated three times, each with 10 bottles.

[0035] After the reaction finishes, measure the amount of lactic acid in the reaction solution according to the following method:

[0036] The reaction products were qualitatively and quantitatively analyzed by high performance liquid chromatography (Agilent 1100 Series HPLC, Beijing Agilent Co., Ltd., the separation column was: Alltech OA-1000 Organic Acids, diluted with H 2 SO 4 The aqueous solution is the mobile phase, the flow rate is 0.3ml / min, the ultraviol...

Embodiment 2

[0043] Embodiment 2, glycerol oxidation direct synthesis lactic acid

[0044] 2 g of glycerol (Glycerol A.R. Beijing Chemical Reagent Company) and 1.73 g of sodium hydroxide (Sodiumhydroxide A.R. Beijing Beihua Fine Chemical Co., Ltd.) were dissolved in 40 mL of water and transferred to a 100 mL three-neck round bottom flask. Add 0.10g Au / C catalyst (World Gold Council World Gold Council), feed 1atm flow rate and be the O of 70ml / min 2 , heated to 140°C, and reacted for 2 hours. The experiment was repeated three times, each with 10 bottles.

[0045] After the reaction, according to the method described in Example 1, the amount of lactic acid in the reaction solution was measured.

[0046] The chromatographic detection results of the reaction products are shown in Figure 2. Lactic acid standard curve is y=277504x-13.315, R 2 = 0.9999. The result shows that the retention time of the peak of the product lactic acid on the chromatogram is exactly the same as that of the lacti...

Embodiment 3

[0048] Embodiment 3, glycerol oxidation directly synthesizes lactic acid

[0049] 0.8 g of glycerol (Glycerol A.R. Beijing Chemical Reagent Company) and 3.46 g of potassium hydroxide (Potassium hydroxide A.R. Beijing Beihua Fine Chemical Co., Ltd.) were dissolved in 40 mL of water and transferred to a 100 mL three-neck round bottom flask. Add 0.13g Au / ZrO 2 Catalyst catalyst (World Gold Council World Gold Council), the O 2 , heated to 60°C, and reacted for 4 hours. The experiment was repeated three times, each with 10 bottles.

[0050] After the reaction, according to the method described in Example 1, the amount of lactic acid in the reaction solution was measured.

[0051] The chromatographic detection results of the reaction products are shown in Figure 3. Lactic acid standard curve is y=277504x-13.315R 2 = 0.9999. The result shows that the retention time of the peak of the product lactic acid on the chromatogram is exactly the same as that of the lactic acid standard...

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Abstract

The invention discloses a synthesis method of lactic acid by using glycerol, which is characterized in that the glycerol is adopted as the material; the lactic acid is obtained via reaction under the alkaline condition with the reaction pressure of 1 to 15 atm, the reaction temperature of 20 to 140 DEG C, the reaction time of 0.5 to 48 h and the catalyst and the oxidant existing; and when the synthesis method of lactic acid is adopted, the glycerol can be partially converted into the lactic acid with conversion rate of the glycerol being 12% to 70%, selectivity of the lactic acid being 33% to 81% and yield of the lactic acid being 9.7% to 32%. The synthesis method of lactic acid by using glycerol has the advantages that high reaction temperature is not needed, and the reaction can be conducted under the condition of normal temperature or close to normal temperature, thus a large amount of energy is saved; the reaction is conducted under the condition of atmospheric pressure or close to atmospheric pressure with the oxygen existing, thus requirement to equipments is low and investment is small; and the reaction system is simple which is beneficial to industrialization, and the catalyst has long service life without loss.

Description

technical field [0001] The invention relates to a method for synthesizing lactic acid from glycerin. Background technique [0002] Lactic acid is an organic acid with a wide range of uses. It has a wide range of uses in food, medicine, light industry, tobacco, plastics and paints. Polylactic acid obtained from lactic acid is the future due to its biodegradability and excellent physical and chemical properties. Ideal polymer material. At present, the main methods of industrial production of lactic acid are starch fermentation and chemical synthesis. Among them, the starch fermentation method has problems such as uncontinuous production, large consumption of raw materials, high energy consumption, and unstable product quality; the chemical synthesis methods mainly include lactonitrile method and acrylonitrile method. Low consumption, but due to the use of acetaldehyde and highly toxic hydrocyanic acid and other substances in the raw materials, there is a greater risk of poll...

Claims

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Application Information

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IPC IPC(8): C07C59/08C07C51/215
Inventor 刘海超沈宜泓李宏佳
Owner PEKING UNIV
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