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Salvia miltiorrhiza total phenolic acid gastric stasis preparation

A technology of total salvianolic acid and gastric retention, applied in the field of medicine, can solve the problems of salvianolic acid stability easily affected by pH, low bioavailability, poor membrane permeability, etc., to prolong effective absorption time and increase gastrointestinal absorption , The effect of increasing the retention rate

Inactive Publication Date: 2008-07-30
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Salvianolic acid belongs to the class III drug of the drug biopharmaceutical classification system, that is, it has high solubility and poor membrane permeability
Studies have shown that the stability of salvianolic acid is easily affected by pH, and it is prone to degradation when pH>6, so salvianolic acid is unstable under the pH condition of the small intestine, and the absorption rate in the middle and rear part of the small intestine is very low, which is Main reasons for low bioavailability of salvianolic acid after oral administration

Method used

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  • Salvia miltiorrhiza total phenolic acid gastric stasis preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Salvia miltiorrhiza total phenolic acid intragastric floating tablet 1

[0047] Salvia Total Phenolic Acids 25%

[0048] Hydroxypropyl Methyl Cellulose 40%

[0049] Stearyl Alcohol 20%

[0050] Lactose 9%

[0051] Sodium bicarbonate 5%

[0052] Magnesium Stearate 1%

[0053] Grind the main ingredient and auxiliary materials finely, and pass through an 80-mesh sieve for later use. Weigh the main drug and auxiliary materials in the prescribed amount, mix them evenly and then sieve them, and press the powder directly into tablets to obtain smooth and clean stomach-floating tablets with a hardness of 3 to 5 kg. The floating performance was observed by in vitro method, the tablet floated immediately, and the floating time lasted >8h.

Embodiment 2

[0054] Example 2: Salvia miltiorrhiza total phenolic acid intragastric floating tablet 2

[0055] Salvia Total Phenolic Acids 25%

[0056] Hydroxypropyl Methyl Cellulose 25%

[0057] Stearyl Alcohol 10%

[0058] Lactose 35%

[0059] Sodium bicarbonate 4%

[0060] Magnesium Stearate 1%

[0061] Grind the main ingredient and auxiliary materials finely, and pass through an 80-mesh sieve for later use. Weigh the main drug and auxiliary materials in the prescribed amount, mix them evenly and then sieve them, and press the powder directly into tablets to obtain smooth and clean stomach-floating tablets with a hardness of 3 to 5 kg. The floating performance was observed by in vitro method, starting to float in 1.2 minutes, and continuing to float for 5 hours.

Embodiment 3

[0062] Example 3: Salvia miltiorrhiza total phenolic acid intragastric floating tablet 3

[0063] Salvia Total Phenolic Acids 25%

[0064] Hydroxypropyl Methyl Cellulose 60%

[0065] Stearyl Alcohol 10%

[0066] Sodium bicarbonate 4%

[0067] Magnesium Stearate 1%

[0068] Grind the main ingredient and auxiliary materials finely, and pass through an 80-mesh sieve for later use. Weigh the main drug and auxiliary materials in the prescribed amount, mix them evenly and then sieve them, and press the powder directly into tablets to obtain smooth and clean stomach-floating tablets with a hardness of 3 to 5 kg. The floating performance was observed by in vitro method, starting to float in 0.2 minutes, and the continuous floating time was more than 8 hours.

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Abstract

The invention belongs to the medicine technical field, in particular to a gastric retention preparation containing total salvianolic acid. The invention adopts the effective position of the Chinese medicine of total salvianolic acid as the main component, and the stomach retention preparation is made with acceptable auxiliary materials in pharmacy. The preparation of the invention is gastric floating preparation or stomach mucoadhesive preparation; the invention can significantly prolong the retention time of the total salvianolic acid on the stomach and the upper part of small intestine, enhance stability of medicine, and prolong effective absorption time and improve the utilizing degree of salvianolic acid biology through the double effect of enhancing the medicine stability and prolonging the effective absorption time. The invention can not only improve gastrointestinal absorption, but also have better efficacy in treating gastric ulcer and some other diseases; the invention also has simple production technique and is easy for industrialization; the invention is easy for the patients to take with good compliance.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a gastric retention preparation containing salvianolic acid. Background technique [0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza Bunge, which is one of the most commonly used medicinal materials in traditional medicine in my country. Modern chemical and pharmacological studies have shown that Salvia miltiorrhiza mainly contains fat-soluble tanshinones and water-soluble salvianolic acids, among which salvianolic acid is the main effective part of Salvia miltiorrhiza, which has significant protection against cardiovascular system and brain damage, anti-hepatic Fibrosis, treatment of gastric ulcer, induction of apoptosis and prevention of neurodegenerative diseases, etc., its active ingredients include salvianolic acid A (salvianolic acid A), B (salvianolic acid B), C, D, E, F, G , danshensu, protocatechualdehyde, salviol, rosmarinic acid, lithospe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K31/343A61K9/16A61K9/20A61K47/32A61K47/36A61K47/38A61P1/04A61P1/16A61P9/10A61P25/00A61K125/00
Inventor 韩丽妹王建新高东燕马琳怡
Owner FUDAN UNIV
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