Acidum folicum effervescent tablet and preparation thereof

A technology of effervescent tablets and folic acid, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of hindering the production of effervescent folic acid tablets, increased perinatal deaths, and low birth rates. Weight gain and other issues

Inactive Publication Date: 2008-11-12
广东世信药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Taking 5mg folic acid tablets to women of childbearing age or before and after pregnancy will cause adverse consequences, such as causing severe nervous system damage, inducing convulsions, seriously affecting the metabolism of zinc in pregnant women and ca

Method used

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  • Acidum folicum effervescent tablet and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] [Example 1] Folic acid effervescent tablet

[0066] prescription:

[0067] The dosage per 1000 tablets is

[0068] Folic acid 0.4g

[0069] Stevia 35g

[0070] Pigment 6.6g

[0071] Tartaric acid 685g

[0072] Sodium bicarbonate 400g

[0073] Sodium chloride 100g

[0074] Macrogol 6000 100g

[0075] Lactose 553g

[0076] Low-substituted hydroxypropyl cellulose 80g

[0077] Orange Flavor 20g

[0078] Orange flavor 20g

[0079] Preparation Process:

[0080] (1) Material drying

[0081] Dry tartaric acid, sodium bicarbonate, lactose, sodium chloride, and low-substituted hydroxypropyl cellulose at below 50°C, and dry polyethylene glycol 6000 at below 30°C, so that the water content of each material is ≤1.5%;

[0082] (2) Crushing and screening

[0083] Sodium bicarbonate, 342.5g of tartaric acid, polyethylene glycol 6000, lactose, and low-substituted hydroxypropyl cellulose were pulverized respectively, and passed through an 80-mesh sieve; the particle size of...

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Abstract

The invention relates to a folic acid effervescent tablet. Each 1000 effervescent tablets are prepared by folic acid which is taken as an active ingredient and various carriers, the folic acid effervescent tablet comprises the following compositions by weight portion: 0.3 to 0.5g of folic acid, 650 to 720g of tartaric acid, 370 to 430g of sodium bicarbonate, 80 to 120g of sodium chloride, 600080 to 120g of polyethyleneglycol, 520 to 580g of lactose, 50 to 150g of low-substituted hydroxyproxyl cellulose, and 35 to 45ml of 3 percent PVP absolute ethyl alcohol solution. The tartaric acid, the sodium chloride and the low-substituted hydroxyproxyl cellulose adopt internal and external additions. The folic acid effervescent tablet can be disintegrated within 2 minutes, has convenient administration, good taste, quick absorption, and high bioavailability, and can form a cup of drink with good color, odor and flavor after the effervescent tablet is placed into the water for effervescence, thereby improving the dosing flexibility, meeting dosing requirements of different pregnant women, and better meeting the medical need.

Description

technical field [0001] The invention relates to a folic acid effervescent tablet and a preparation method thereof, belonging to the improvement of pharmaceutical dosage forms. Background technique [0002] Neural Tube Defects (NTD for short) is a severe congenital disorder with a relatively high incidence rate. It is a serious birth defect disease, accounting for about 1 / 3 of birth defects, and it is a major problem that needs to be solved urgently worldwide. . In developed countries, NTDs range from 0.5 to 3.6 per 1000 births. my country is an area with a high incidence of neural tube defects, with nearly 100,000 cases occurring every year, which is 10 times higher than the average incidence in other regions of the world. [0003] Folate deficiency in women of childbearing age is an important cause of NTD. Folic acid has long been used to prevent NTD. Studies have shown that folic acid supplementation for women from one month before pregnancy to the end of three months a...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61K9/46A61K47/38A61P3/02A61P25/00
Inventor 李宏
Owner 广东世信药业有限公司
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