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Gallic acid chelates composition and uses thereof

A technology of gallic acid and chelate, which is applied in the direction of drug combination, medical preparations containing active ingredients, metabolic diseases, etc., can solve the problems of high toxicity, high price, unsatisfactory absorption rate, etc., and achieve the effect of high absorption rate

Inactive Publication Date: 2008-12-24
惠州市昆泰精细化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These compounds meet the needs of people to a certain extent, but these compounds have the disadvantages of high toxicity, unsatisfactory absorption rate and high price.

Method used

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  • Gallic acid chelates composition and uses thereof
  • Gallic acid chelates composition and uses thereof
  • Gallic acid chelates composition and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of embodiment 1 gallic acid chelated calcium

[0017] Add 8.5 g of gallic acid to 50 ml of 65% aqueous ethanol solution, stir, and heat to 60°C to dissolve the sample completely. Add 10 g of calcium carbonate in batches without stopping the stirring, and continue stirring at a constant temperature until no bubbles are generated. After cooling to room temperature, cool in an ice bath until the calcium gallate chelate precipitates completely. The reactant was suction-filtered, the solid was washed with ethanol, and vacuum-dried at room temperature to obtain 12.3 g of gallic acid chelated calcium (97.5% yield).

Embodiment 2

[0018] The preparation of embodiment 2 gallic acid chelated magnesium

[0019] Add 6.8 g of gallic acid to 50 ml of 65% aqueous ethanol solution, stir, and heat to 50° C. to dissolve the sample completely. Add 6.8 g of magnesium carbonate in batches while stirring, and continue stirring at constant temperature until no bubbles are generated. The reactant was cooled to room temperature, cooled in an ice bath until the precipitation was complete, and filtered with suction. The obtained solid was washed with ethanol, and dried under vacuum at room temperature to obtain 8.0 g of magnesium gallic acid chelate (yield 92%).

Embodiment 3

[0020] The preparation of embodiment 3 gallic acid chelated zinc

[0021] Add 6.8g gallic acid to 50ml 75% ethanol aqueous solution, stir, and heat to 50°C to dissolve the sample completely. While stirring, add zinc carbonate 10g in batches, keep stirring at constant temperature until no bubbles are generated. The reactant was cooled to room temperature, cooled in an ice bath until the precipitation was complete, and filtered with suction. The obtained solid was washed with ethanol, and dried under vacuum at room temperature to obtain 10.2 g of gallic acid chelated zinc (91.2% yield).

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Abstract

The invention discloses a gallic acid chelate compound and an application thereof. The gallic acid chelate compound comprises 70 percent to 95 percent of calcium gallic acid chelate, 0 percent to 8 percent of zinc gallic acid chelate, 0 percent to 2 percent of magnesium gallic acid chelate, 0 percent to 2 percent of strontium gallic acid chelate and 5 percent to 18 percent of inulin. In the invention, the gallic acid chelate is in chelation reaction with the bivalent metallic ion calcium, zinc, magnesium and strontium to prepare the calcium gallic acid chelate, zinc gallic acid chelate, magnesium gallic acid chelate and strontium gallic acid chelate. The gallic acid chelate compound which is prepared through the mixing of the four chelates with the inulin according to a certain proportion can be used for treating and preventing acalcerosis or chlasma. The gallic acid chelate compound has the advantages of high absorption efficiency, low toxicity and cheapness, and meanwhile has the characteristics of antivirus, anti-tumor, anti-mutation and oxidation-resistant activities and a plurality of other physiological and pharmacological activities.

Description

technical field [0001] The invention relates to an organometallic chelate, in particular to a gallic acid chelate composition and its application. Background technique [0002] Life originates from elements, and elements make up life forms. There are generally 29 kinds of life elements, including 11 kinds of constant elements and 18 kinds of trace elements. These elements are indispensable for living organisms to maintain their normal life functions. These 29 elements exist in various valence states in the human body and reach a certain dynamic balance. Once one or several elements deviate from this balance, the body will produce one or that kind of disease. Calcium and magnesium are macro elements; iron, zinc, copper and manganese are trace elements, which play an important role in the human body. The content of these elements in the body is often reduced due to diet or other diseases, which breaks the balance of elements in the body, resulting in more serious diseases or...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61P3/14A61P3/02A61P43/00
Inventor 张博钧
Owner 惠州市昆泰精细化工有限公司
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