Compound medicament intravascular stent and preparation method thereof

Abstract

The invention relates to a composite drug stent and a preparation method thereof. The stent includes a stent body and active drugs; wherein, the stent body is a perforated medical material with good biocompatibility, which can be made by optionally using stainless steel, cobalt-based alloy, titanium alloy, nickel-titanium alloy, or polylactic acid bio-polymer material; the active drugs include special endothelial progenitor cell antibody drug and anti-smooth muscle cell proliferation drug. The internal surface of the perforated stent body is fixedly provided with the special endothelial cell antibody drug, while the external surface of the perforated stent body is coated with the anti-smooth muscle cell proliferation drug. The preparation method includes as follows: (1) pretreating the surface of the stent body; (2) making holes; (3) post-treating the surface of the stent body; (4) dispensing medicines; (5) coating the external surface; (6) fixing the internal surface; (7) drying at low temperature. The preparation method can selectively absorb endothelial progenitor cells and facilitate in repairing endodermis, and can effectively inhibit the proliferation and migration of vascular smooth muscle cells, persistently and effectively reduce the newborn endangium, effectively prevent the stent from narrowing, and avoid the risk of tardive thrombosis.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a novel composite medicine vascular stent and a preparation method thereof. Background technique [0002] Since 1987, when Sigwart et al first applied intravascular metal stents to coronary arteries, it has provided a good way to treat vascular occlusive diseases. The main reason for the efficacy of treatment (PCI). The main mechanism of in-stent restenosis is the hyperplasia of vascular intima and the delay of vascular endothelialization. Therefore, the prevention and treatment of in-stent restenosis is mainly to promote the rapid repair of vascular endothelium and inhibit the excessive proliferation of smooth muscle cells. [0003] The wide application of drug-eluting stents has greatly reduced the occurrence of in-stent restenosis. Although drug-eluting stents can effectively inhibit the proliferation of smooth muscle cells and reduce and prevent intimal hyperplasia, they delay t...

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Problems solved by technology

[0003] The wide application of drug-eluting stents has greatly reduced the occurrence of in-stent restenosis. Although drug-eluting stents can effectively inhibit the proliferation of smooth muscle cells and reduce and prevent intimal hyperplasia, they delay the repair of vascular endothelium; CD34 antibody-engineered stents Although endothelial progenitor cells can be captured in blood vessels based on the antigen-antibody binding theory and rapidly endothelialized on the surface of vascular stents, the specific inhibition of smooth muscle cells is ignored

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