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Red rice vinegar with antihypertensive function

A technique of red yeast rice vinegar and blood pressure lowering, applied in the field of red yeast rice vinegar, can solve the problems of high random factors, difficulty in strain screening, inability to know GABA, etc., and achieve the effect of increasing added value

Inactive Publication Date: 2008-12-31
义乌市丹溪酒业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In 1979, Professor Yuan Tengzhang of Japan Agricultural University, according to the records of Chinese medicine theory recorded by Yuan Dynasty doctor Zhu Danxi, revealed that red yeast rice has the effect of invigorating blood circulation, and found that the products fermented with red yeast rice have the effect of lowering blood fat, blood pressure, and blood sugar on the human body. Efficacy: In 1987, Kohama et al. isolated GABA and acetylcholine from red yeast rice, which has the effect of lowering blood pressure. Chinese patent application (02158370.6) Monascus mutant strain and its use in the preparation of blood pressure-lowering active fermentation products, although it has screened the GABA content Monascus mutant strain with higher and lower citrinin content and related to its culture method, pharmaceutical composition and food additives, but the screening of this strain is difficult, and the survival rate after mutation is low, and the random factor is high; in addition, from the It is not known in the patent application documents whether the GABA in Monascus or its fermented product is inactivated by factors such as temperature and pH value, thus losing its medicinal properties for treating hypertension

Method used

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  • Red rice vinegar with antihypertensive function
  • Red rice vinegar with antihypertensive function
  • Red rice vinegar with antihypertensive function

Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1

[0051] Take Danxi-1 (Monascus red strain Danxi-1), under aseptic conditions (sterile room or ultra-clean workbench), pick a small amount of bacteria by inoculation, transfer to sterilized The solid maltose agar medium culture dish was placed in an incubator at 25°C ± 1°C for activation and cultivation for 96 hours. Take out the activated strains for 96 hours, insert the activated strains into the sterilized first-grade solid maltose agar medium in the same way under aseptic conditions, and cultivate them at 25°C ± 1°C for 96 hours, which is Danxi-1 No. 1 seed.

[0052] Adopt 500 milliliter glass triangular flasks, fill 100 milliliters of prepared liquid maltose culture medium, sterilize at 15 pounds for 30 minutes and set aside. Take Danxi-1 first-class seeds, under aseptic conditions, inoculate in 500 ml glass triangular flasks with 100 ml of liquid maltose medium, the inoculation amount of first-class seeds is five triangular flasks connected to each petri dish, to After c...

manufacture example 2

[0054] Take Danxi-3 (Monascus strain Danxi-3), under aseptic conditions (sterile room or ultra-clean workbench), pick a little strain by inoculation, transfer to the sterilized Place the solid maltose agar medium culture dish in an incubator at 25°C ± 1°C for activation and culture for 168 hours. Take out the strains activated for 168 hours, insert the activated strains into the sterilized first-grade solid maltose agar medium in the same way under aseptic conditions, and cultivate them at 25°C ± 1°C for 168 hours, which is Danxi-3 first-class seed.

[0055] Adopt 500 milliliter glass triangular flasks, fill 100 milliliters of prepared liquid maltose culture medium, sterilize at 15 pounds for 30 minutes and set aside. Get Danxi-3 primary seeds, under aseptic conditions, inoculate in 500 ml glass triangular flasks with 100 ml liquid maltose medium, the inoculation amount of primary seeds is five triangular flasks connected to each petri dish, to After 168 hours of shaker cult...

Embodiment 1

[0057] Steam the early indica rice used for making koji with water, then add Danxi No. 1 as the secondary seed liquid in the above manufacturing example 1 into the early indica rice, stir and ferment evenly for 5 days to make red koji, and dry the above-mentioned red koji Standby; take red koji distiller's grains and rice skin, add red koji, then add water and mix well, and ferment for 200 hours at a temperature of 25°C and a pH value of 6.0 to make functional red koji distiller's grains; wherein the red koji distiller's grains , the weight ratio of rice skin and red yeast rice is: 2.0: 1.0: 0.11; the weight ratio of the three raw materials and water is 100: 150; the selected organic glutinous rice is used as raw material, soaked in water for 30 hours, so that the raw material can fully absorb water, and the soaked After the raw materials are evenly steamed for 10 minutes, then add water at 25-35°C with a weight ratio of 100% of the raw materials for fermentation; in the above ...

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Abstract

The invention relates to a red yeast vinegar having the blood pressure lowering function; and the red yeast vinegar is prepared by the following processes of: taking glutinous rice as a raw material, steaming and boiling the glutinous rice, and then adding distillers yeast made of red yeast and supplementary materials as well as functional red yeast wine lees with the weight percent of 10 percent to 20 percent of the raw material for undergoing initial fermentation and secondary fermentation, then pressing the mixture to make the red yeast yellow wine, and recovering the red yeast wine lees, and the red yeast wine is made into the red yeast vinegar having the blood pressure lowering function through the acetic acid liquid fermentation; the invention fully utilizes the supplementary material of red yeast wine lees for producing the red yeast wine, thereby increasing the added value and preparing the red yeast vinegar with high GABA content and blood pressure lowering function; and the red yeast vinegar has an unexpected effect to the treatment and prevention of hypertension, and also has the auxiliary blood pressure lowering function.

Description

technical field [0001] The invention relates to a metabolite of red yeast rice, in particular to a red yeast vinegar with the function of lowering blood pressure. Background technique [0002] Hypertension is a common disease with elevated blood pressure in the systemic circulation as the main clinical manifestation. It often involves blood vessels, especially small and small arteries throughout the body, and important organs such as the heart, kidney, and brain, and often causes stroke and chronic cardiac insufficiency. , renal failure and other complications, the existing antihypertensive drugs can be divided into: (1) diuretics, hydrochlorothiazide, etc., but the use of these drugs will cause adverse reactions such as aggravating hyperlipidemia and reducing glucose tolerance; (2) ) Angiotensin I-converting enzyme inhibitors and angiotensin II receptor blockers, captopril, losartan, etc., but the use of these drugs may cause adverse reactions such as hypotension, cough, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12J1/00
Inventor 陈豪锋朱睦元朱丹华薛临生陈铭朱兰琴
Owner 义乌市丹溪酒业有限公司
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