Preparation of carbonate-containing hydroxylapatite powder

Abstract

The invention relates to a method for preparing hydroxyl apatite powder containing carbonate by introducing carbon dioxide gas for pressurization by adopting a hydrothermal method, which pertains to the field of inorganic non-metallic material. The production method is as follows: calcium nitrate and dipotassium hydrogen phosphate are taken as raw materials, the two dissolve in water in accordance with certain concentration respectively to form solutions which are mixed in accordance with certain Ca / P; and the mixture is put into a high-pressure reaction kettle. Before the reaction kettle is heated, carbon dioxide gas with certain pressure is led in. The hydrothermal reaction is realized by the setting of parameters such certain stirring speed, temperature rise speed, heating temperature and holding time and the like. After the reaction, the hydroxyl apatite powder containing carbonate is obtained by filtration, cleaning and drying. The method is simple and easy to be operated and theobtained power has high degree of crystallinity; the crystal grain takes the shape of rod with primary particle size length of about 500nm and length-diameter ratio of about 2; and carbonate belongs to type A and type B mixed substitution in hydroxyl apatite, and the hydroxyl apatite powder containing carbonate is suitable for industrial production in the biomaterial field.

Description

technical field [0001] The invention relates to a method for preparing carbonate-containing hydroxyapatite powder, specifically a method for preparing carbonate-containing hydroxyapatite powder by using hydrothermal and carbon dioxide gas pressurization, and belongs to the field of inorganic non-metallic materials. Background technique [0002] In physiological bone, a small amount of elements enter the hydroxyapatite lattice in the form of substitution, and the main substitute is carbonate, which accounts for about 5% to 8% in bone mineral mass. Studies have shown that consciously introducing some carbonate groups during the artificial synthesis of hydroxyapatite crystals can improve the bioactivity and osteoconductivity of the material. Carbonate-containing hydroxyapatite powder is currently widely used in hard tissue repair and replacement, and due to its excellent biocompatibility and chemical reactivity to different biological materials, it is also expected to become a ...

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Problems solved by technology

[0005] It can be seen from the above-mentioned published patents that the sol-gel method is a common preparation method for carbonate-containing hydroxyapatite. This method has a long cycle and low output, which is not conducive to industrial production. The secondary crystallization process is likely to cause powder Pollution; the production cycle of the novel in-situ deposition method is too long, and the glass contains many other metal elements, so it is not easy to obtain hydroxyapatite powder doped with only carbonate groups; there have been many reports on the preparation of hydroxyapatite by hydrothermal method , which proves that the preparation of powder by hydrothermal method has short cycle time, good crystal crystallinity and less pollution, and is especially suitable for fields with high requirements on powder purity, such as the field of biological materials.

However, the technical scheme of preparing carbonate-containing hydroxyapatite powder by hydrothermal and carbon dioxide gas pressure has not been reported yet.

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