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Superparamagnetism nano particle jointly modified by aminosilane coupling agent and hyskon and preparation method thereof

An aminosilane coupling agent, superparamagnetic technology, applied in the preparation of the superparamagnetic nanoparticles, in the field of superparamagnetic nanoparticles, can solve the problems of toxic and side effects of the body, complicated operation, etc., and achieve high hydrophilicity, biological Good compatibility and easy operation

Inactive Publication Date: 2009-10-14
ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, for the further combination of dextran-modified superparamagnetic nanoparticles and monoclonal antibodies, glutaraldehyde cross-linking method and sodium periodate oxidation method are mainly used at present, the operation is more complicated, and the glutaraldehyde and periodic acid used Chemical reagents such as sodium may cause toxic side effects to the body

Method used

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  • Superparamagnetism nano particle jointly modified by aminosilane coupling agent and hyskon and preparation method thereof
  • Superparamagnetism nano particle jointly modified by aminosilane coupling agent and hyskon and preparation method thereof
  • Superparamagnetism nano particle jointly modified by aminosilane coupling agent and hyskon and preparation method thereof

Examples

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Embodiment 1

[0032] Example 1, Preparation of Aminosilane Coupling Agent and Dextran Co-modified Superparamagnetic Nanoparticles

[0033] In this example, the aminosilane coupling agent AEAPS is used to prepare superparamagnetic Fe modified by AEAPS and dextran. 3 o 4 Nanoparticles (AEAPS / Dextran-SPION), including the following steps:

[0034]a. Preparation of dextran-coated superparamagnetic Fe 3 o 4 Nanoparticles (Dextran-SPION)

[0035] Weigh ferrous chloride 0.86g (4.33mmol), ferric chloride 1.99g (7.36mmol) and Dextran T-10 (relative molecular mass 10000, BBI company) 3.5g (0.35mmol) (Fe 2+ , Fe 3+ The molar ratio of glucan and dextran is 1:1.7:0.08), add 30mL of three-distilled water, stir to dissolve, and then under nitrogen protection, temperature is 60 ℃ and stirring speed is 1000r / min at the speed of 1mL / min Add dropwise ammonia water with a mass percentage concentration of 25% to adjust the pH to 8.0. After the dropwise addition, continue to stir and react at a constant te...

Embodiment 2

[0038] Example 2, Preparation of Aminosilane Coupling Agent and Dextran Co-modified Superparamagnetic Nanoparticles

[0039] In this example, the aminosilane coupling agent APTES is used to prepare superparamagnetic Fe modified by APTES and dextran. 3 o 4 Nanoparticles (APTES / Dextran-SPION), including the following steps:

[0040] a. Preparation of Dextran-SPION

[0041] Weigh ferrous sulfate 1.20g (4.33mmol), ferric sulfate 2.94g (7.36mmol) and Dextran T-10 (relative molecular mass 10000, BBI company) 3.5g (0.35mmol) (Fe 2+ , Fe 3+ The molar ratio of Dextran and Dextran is 1:1.7:0.08), add 30mL of three-distilled water, stir to dissolve, and then add dropwise at a rate of 1mL / min under the conditions of nitrogen protection, temperature of 60°C and stirring speed of 1000r / min. Adjust the pH to 8.0 with ammonia water with a concentration of 25% by mass. After the dropwise addition, continue to stir and react for 1 hour to obtain a black jelly. Cool naturally to room tempera...

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Abstract

The invention discloses superparamagnetism nano particle jointly modified by an aminosilane coupling agent and hyskon, and a preparation method thereof. The superparamagnetism nano particle has a core-shell structure; the inner core of the particle is magnetic ferroferric oxide; the surface of the inner core is a hyskon coating layer; and the external surface of the hyskon coating layer is connected with the aminosilane coupling agent. The preparation method comprises the following steps of: firstly preparing the hyskon-coated superparamagnetism ferroferric oxide nano particle; and secondly modifying the surface of the hyskon-coated superparamagnetism ferroferric oxide nano particle by the aminosilane coupling agent. The superparamagnetism nano particle has high hydrophilicity, steadily spreads in water phase, can reduce the phagotrophy quantity of reticulo endothelium, extends cycle time in water, is full with amidogen at the surface thereof, can conveniently combine with monoclonal antibody so as to improve active targeting, causes no toxic side effect to human body, and has good biocompatibility, simple preparation method and good application prospect in the early diagnosis of malignant tumor and the treatment field of targeting.

Description

technical field [0001] The invention relates to a magnetic nanoparticle, in particular to a superparamagnetic nanoparticle co-modified with an aminosilane coupling agent and dextran, and also to a preparation method of the superparamagnetic nanoparticle. Background technique [0002] Malignant tumors seriously endanger human health. Every year, 10 million people around the world suffer from cancer. Most patients have already had tumor cell infiltration and metastasis when they are diagnosed. They miss the chance of surgery and can only rely on drug treatment. Therefore, the early diagnosis of malignant tumors and the research of efficient, safe and economical targeted anti-tumor drugs have become clinical problems to be solved urgently. In recent years, the development of nanotechnology has provided new opportunities for early diagnosis and targeted therapy of malignant tumors. Superparamagnetic nanoparticles have been widely used in magnetic resonance imaging diagnosis, ma...

Claims

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Application Information

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IPC IPC(8): B01J13/02H01F1/11A61K47/36A61K49/12
Inventor 邓均郑峻松贺娟
Owner ARMY MEDICAL UNIV
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