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Rizatriptan benzoate film agent

A technology of rizatriptan benzoate and film preparations, which is applied in medical preparations of non-active ingredients, organic active ingredients, nervous system diseases, etc., to achieve the effects of convenient use, low production cost, and rapid dissolution

Inactive Publication Date: 2009-11-11
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For migraine patients, they always hope to be treated at the first moment; and it is reported that the bioavailability of oral rizatriptan benzoate tablets is only 45%, so there is an urgent need for a fast-acting, high-bioavailability preparation

Method used

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  • Rizatriptan benzoate film agent
  • Rizatriptan benzoate film agent
  • Rizatriptan benzoate film agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] prescription:

[0063] Rizatriptan Benzoate 10g

[0064] HPMC 56g

[0065] Glycerin 10g

[0066] Tween-80 2g

[0067] Titanium dioxide 2g

[0068] Aspartame 20g

[0069] Preparation:

[0070] Take HPMC and add 300ml of distilled water to dissolve, pass through 80 mesh sieve, remove insoluble matter, then add rizatriptan benzoate, glycerin, Tween-80, stir to dissolve. Add the finely ground titanium dioxide and aspartam into the slurry, stir, and leave overnight for vacuum degassing. Then stretch the membrane solution on a stainless steel belt, dry at 60°C, emboss with an embossing roller, cut it into a certain size, peel it off from the stainless steel belt, and seal the package.

Embodiment 2

[0072] Rizatriptan Benzoate 30g

[0073] HPMC 59.9g

[0074] PEG400 5g

[0075] Titanium dioxide 3g

[0076] Acesulfame K 2g

[0077] Sunset Yellow 60 0.1g

[0078] Take HPMC and add 300ml of distilled water to dissolve, pass through 80 mesh sieve to remove insoluble matter, then add rizatriptan benzoate, PEG 400, acesulfame potassium and sunset yellow 60, stir to dissolve. Add finely ground titanium dioxide into the slurry, stir, and leave overnight for vacuum degassing. Then stretch the membrane solution on a stainless steel belt, dry at 60°C, emboss with an embossing roller, cut it into a certain size, peel it off from the stainless steel belt, and seal the package.

Embodiment 3

[0080] Rizatriptan Benzoate 20g

[0081] PVA 46g

[0082] Glycerin 15g

[0083] Titanium dioxide 1g

[0084] Sodium saccharin 15g

[0085] Citric acid 2g

[0086] L-menthol 1g

[0087] Take PVA and add 100ml of distilled water to dissolve, pass through an 80-mesh sieve to remove insoluble matter, then add rizatriptan benzoate, glycerin, sodium saccharin and citric acid, and stir to dissolve. L-menthol was dissolved in ethanol and added to the film-forming slurry. Add finely ground titanium dioxide into the slurry, stir, and leave overnight for vacuum degassing. Then stretch the membrane solution on a stainless steel belt, dry at 60°C, emboss with an embossing roller, cut it into a certain size, peel it off from the stainless steel belt, and seal the package.

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PUM

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Abstract

The invention discloses a rizatriptan benzoate film agent. The film agent comprises the following components by weight percentage: 1-40 percent of rizatriptan benzoate, 40-98 percent of macromolecule film-forming material, 0-20 percent of plasticizer, 0-3 percent of titanium pigment, and 1-30 percent of flavoring agent. The high molecular film-forming material comprises more than one of the following components of hydroxypropyl methylcellulose, hydroxy propyl cellulose, polyvinyl alcohol, polyvinyl pyrrolidone, sodium alginate, polyoxyethylene, bletilla mucilage, cornstarch, or carrageenan. The film agent has rapid dissolving out, good stability and high bioavailability, can release medicaments on the surface of a mucosa, and absorb the medicaments quickly, is convenient in use, quick in effect, excellent in biological effectiveness, good in adaptability, popular by patients, has good formability, can be adhered at the drug administration position after drug administration, and keeps the drugs not to be dispersed, can keep the original state to release the drugs continuously, thus having accurate dosage; and no dust explosion occurs during the production process, thus being possible to solve the problems of labor security and environmental pollution.

Description

technical field [0001] The invention relates to a rizatriptan benzoate preparation. Background technique [0002] Migraine is a common clinical cerebrovascular disease, which seriously affects the daily life and work of patients. Epidemiological surveys show that the incidence rate of migraine in western countries is 10%, and in my country the incidence rate is 4.2-14.6%, and the incidence rate of women (18%) is higher than that of men (6%). [0003] Currently, the drugs for clinical treatment of migraine include: analgesics (such as Sanlitong), ergotamine preparations (such as methysergide, dihydroergot, ergotamine) and 5-HT1B / 1D receptor agonists (triptans). )Wait. Painkillers and ergotamine preparations are old drugs. Although they can relieve the symptoms of migraine, both types of drugs have serious side effects, and their specificity is not strong. [0004] Triptans are a new generation of drugs for the treatment of migraine. In February 1991, the first triptan drug...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4196A61K47/38A61K47/36A61K47/34A61K47/32A61P25/06A61K47/10A61K47/26
Inventor 侯惠民陈芳
Owner SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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