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Compound sustained-release preparation for paracetamol and pseudoephedrine

A technology for paracetamol and sustained-release preparations, which is applied in the field of medicine and achieves the effects of stable blood drug concentration, fewer medication times, and reduced medication times.

Active Publication Date: 2009-12-09
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there is no specific treatment at all, it is not necessary for the virus to be firm, and only symptomatic treatment can be used to relieve many symptoms of the common cold

Method used

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  • Compound sustained-release preparation for paracetamol and pseudoephedrine
  • Compound sustained-release preparation for paracetamol and pseudoephedrine
  • Compound sustained-release preparation for paracetamol and pseudoephedrine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] prescription:

[0019] Acetaminophen

325g

Pseudoephedrine Hydrochloride

90g

Hypromellose E5

40g

carnauba wax

15g

microcrystalline cellulose

36g

10% Povidone K 30 aqueous solution

Appropriate amount

Magnesium stearate

Appropriate amount

[0020] Coating prescription:

[0021] Opadry

15g

pure water

Add to 100ml

[0022] Preparation:

[0023] (1) Preparation of granules: Hypromellose E5 and microcrystalline cellulose are respectively passed through 80 mesh sieves, fully mixed with equal increment method, and then mixed with acetaminophen, pseudoephedrine hydrochloride and Brazil Palm wax mixed well with 10% povidone K 30 The aqueous solution is a soft material made of adhesive, wet granules are prepared through a 20-mesh sieve, dried at 60°C, granulated through a 20-mesh sieve, and set aside.

[0024] (2) Preparation of coating liquid Add O...

Embodiment 2

[0035] prescription:

[0036] Acetaminophen

500g

Pseudoephedrine Hydrochloride

60g

Hypromellose K15

6g

Hypromellose E6

75g

microcrystalline cellulose

45g

10% Povidone K 30 aqueous solution

Appropriate amount

stearic acid

Appropriate amount

[0037] Coating prescription:

[0038] Pseudoephedrine Hydrochloride

30g

Cellulose acetate

70.5g

water

Appropriate amount until completely dissolved

[0039] Preparation:

[0040] (1) Preparation of granules Hypromellose K15, Hypromellose E6, and microcrystalline cellulose are passed through a 80-mesh sieve respectively, mixed evenly, and then mixed evenly with acetaminophen and pseudoephedrine hydrochloride to obtain 10% Povidone K 30 The aqueous solution is a soft material made of adhesive, wet granules are prepared through a 20-mesh sieve, dried at 60°C, granulated through a 20-mesh sieve, a...

Embodiment 3

[0051] prescription:

[0052] Acetaminophen

650g

pseudoephedrine sulfate

45g

pregelatinized starch

110g

Sodium carboxymethyl starch

20g

Hypromellose K4

7g

Hydroxyethyl cellulose

72g

microcrystalline cellulose

60g

carnauba wax

50g

[0053] 10% Povidone K 30 aqueous solution

Appropriate amount

Talc powder

20g

[0054] Coating prescription:

[0055] Opadry II

30g

pure water

1000ml

[0056] Preparation:

[0057] (1) Each component in the prescription is passed through a 100-mesh sieve respectively, and set aside;

[0058] (2) Preparation of immediate-release granules: Fully mix the prescription amount of pregelatinized starch and 1 / 2 amount of sodium carboxymethyl starch, then mix them with acetaminophen in an equal increment method, and mix them with 10% povidone K 30 The aqueous solution is a so...

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Abstract

The invention relates to a sustained-release preparation taking paracetamol, pseudoephedrine or physiologically acceptable salt as active components. The sustained-release preparation is characterized in that a release system comprises a tablet core and / or a pill core and / or a coating which enables medicines to be slowly released, one part or all of the active components exist in the tablet core and / or the pill core, and the residual part of the active components exist in the coating.

Description

technical field [0001] The invention relates to a sustained-release preparation which takes acetaminophen, pseudoephedrine or a physiologically acceptable salt thereof as active ingredients, and belongs to the field of medicine. Background technique [0002] A cold is an infection of the upper respiratory tract mucosa caused by many different types of viruses. The main symptoms are nasal congestion, sneezing, mild sore throat, and fever. Systemic symptoms include general discomfort, headache, and myalgia. Because there is no specific treatment at all, it is not necessary to make the virus firm, and only symptomatic treatment can be used to promote the relief of many symptoms of the cold. Since there is still no one drug to alleviate the coexisting symptoms, various compound preparations have been listed one after another. These compound preparations are composed of drugs with different curative effects to relieve different symptoms that exist at the same time. If the patie...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/167A61K31/137A61K47/30A61P11/00A61P31/12
Inventor 郑顺利林鹏李育巧
Owner COSCI MED TECH CO LTD
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