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Analgesic agent comprising cyclic phosphatidic acid derivative

An analgesic, straight-chain technology, applied in medical preparations containing active ingredients, non-central analgesics, anti-inflammatory agents, etc.

Active Publication Date: 2009-12-23
OCHANOMIZU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antipyretic analgesics generally have anti-inflammatory and analgesic and antipyretic effects caused by COX blockade, but there are also analgesic and antipyretic drugs that do not have COX blockade effects such as acetaminophen

Method used

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  • Analgesic agent comprising cyclic phosphatidic acid derivative
  • Analgesic agent comprising cyclic phosphatidic acid derivative
  • Analgesic agent comprising cyclic phosphatidic acid derivative

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0057] As additives that can be used in the preparation of preparations for oral administration, for example: excipients such as glucose, lactose, D-mannose, starch, or crystalline cellulose; carboxymethylcellulose, starch, or carboxymethylcellulose; Disintegrants or disintegration aids such as plain calcium; binders such as hydroxypropylcellulose, hydroxypropylmethylcellulose, polyvinylpyrrolidone or gelatin; lubricants such as magnesium stearate or talc; hypromellose Coating agents such as base cellulose, white sugar, polyethylene glycol or titanium oxide; bases such as petrolatum, liquid paraffin, polyethylene glycol, gelatin, kaolin, pure water or solid fat.

[0058] As additives that can be used in the preparation of injection or infusion preparations, distilled water for injection, physiological saline, propylene glycol, etc. can be used as dissolving agents or dissolution aids that can constitute aqueous or instant injections; glucose, sodium chloride, D - Mannose, glyc...

Embodiment

[0065] (1) Experimental method

[0066] biomaterials

[0067] Wister male rats (body weight 300-375 g) were used.

[0068] anaesthetization

[0069] Anesthetized by intraperitoneal administration of urethane 1.1g / Kg for the first time. Observe the depth of anesthesia by the changes of blood pressure and heart rate, and subcutaneously administer 1 / 20-1 / 10 of the initial dose every 1-2 hours to maintain the depth of anesthesia.

[0070] maintenance of breathing

[0071] The trachea of ​​the rat was incised, a tracheal tube was inserted, and breathing was maintained using an artificial respirator (SN-480-7, Shinano, Tokyo). An exhalation gas monitor (1H26, NEC San-ei, Tokyo) was used to monitor the carbon dioxide concentration in exhalation, and the respiratory volume was adjusted to about 3% in the experiment.

[0072] maintenance of body temperature

[0073] A thermistor was inserted into the rectum to continuously monitor the deep body temperature, and the body t...

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PUM

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Abstract

An object of the present invention is to elucidate an analgesic effect as one of new cPA bioactivities and thus to provide a novel analgesic agent. The present invention provides an analgesic agent which comprises a cyclic phosphatidic acid derivative that is one type of phospholipid.

Description

technical field [0001] The present invention relates to an analgesic containing a cyclic phosphatidic acid derivative which is one type of phospholipid. Background technique [0002] The treatment of "pain" in Japan is considered to be lower than that in Europe and the United States. The research environment for basic research related to "pain" is also far worse than that in Europe and the United States. In addition, the society or government's low understanding of "pain" makes it impossible to link pain with treatment. [0003] In order to break through this status quo and improve "pain" medicine, it is necessary to promote activities in Japan in cooperation with front-line medical doctors, researchers engaged in basic research, and people related to the government. Starting from the fact-finding investigation of the treatment of "pain" in Japan or the investigation of its impact on the social economy, etc., to the elucidation of the mechanism of "pain", the development of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/665A61P25/04A61P29/00
CPCA61K31/665A61P25/04A61P29/00
Inventor 室伏贵美子金敷晴美
Owner OCHANOMIZU UNIVERSITY