Nano-Artesunate capsule and preparation process thereof

A technology of artesunate and preparation process, applied in the field of nano artesunate capsules and preparation thereof, can solve the problems of loss of activity, instability, ring breakage and the like, and achieve sustained drug release, convenient operation and good packaging state Effect

Inactive Publication Date: 2010-02-10
SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although both dragon's blood and artesunate are powdery solids, they are easily soluble in organic solvents such as ethanol, but artesunate has a peroxide bridge ring structure, which is unstable, easy to ...

Method used

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  • Nano-Artesunate capsule and preparation process thereof
  • Nano-Artesunate capsule and preparation process thereof
  • Nano-Artesunate capsule and preparation process thereof

Examples

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Embodiment Construction

[0031] The core of the capsule of the present invention is artesunate, the capsule is gelatin, and the capsule is spherical or ellipsoidal.

[0032] The preparation process is to swell gelatin with distilled water to form a colloid, dissolve powdered artesunate in ethanol, dissolve glacial acetic acid in distilled water, take the gelatin solution, and slowly add it dropwise while stirring in a constant temperature water bath at 40°C. The artesunate ethanol solution is adjusted to pH with glacial acetic acid solution, and formaldehyde is slowly dropped into the ice bath to solidify the artesunate capsule, filtered and sterilized, and freeze-dried to obtain artesunate nanocapsule powder.

[0033] The best solution is to dissolve 2g of gelatin with 100ml of distilled water, the weight ratio of gelatin to artesunate is 1:1, and the dissolution temperature of artesunate in ethanol is less than 30°C.

[0034] The present invention utilizes the different solubility of the solid capsu...

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Abstract

The invention relates to a nano-Artesunate capsule and a preparation process thereof. A capsule heart is Artesunate, a capsule film is gelatin, a capsule shape is in a ball shape or an ellipsoid shape, and the diameter of the capsule is 30 nm. The invention adopts the following preparation process: swelling the gelatin by distilled water to form colloid, dissolving powdered Artesunate in ethanol at the room temperature, dissolving glacial acetic acid in the distilled water, taking gelatin solution, slowly dropping the Artesunate ethanol solution under the stirring in a water bath with the constant temperature of 40 DEG C, adjusting pH value with glacial acetic acid solution, slowly dropping formaldehyde under the condition of ice bath, solidifying to form the capsule, and freezing and drying to obtain powder of the nano-Artesunate capsule. The capsule prepared by the invention can be taken orally as well as injected by injection, the dosage is small, and no toxic or side effect occursby taking orally; and the injection cannot cause thrombus, and the like in blood vessels, can support sustained release of medicine delivery, and the injection has high efficiency and long effective period. The grain size of the capsule is uniform, the covering state is good, and the covering rate is 50%; the addition of emulsifier and coagulant aid is not needed during preparation, the process issimple, and the operation is convenient.

Description

technical field [0001] The invention relates to a nano artesunate capsule and a preparation process thereof. Background technique [0002] Artesunate (Artesunate) is a derivative of the semiterpene lactone compound artemisinin, the chemical name is dihydroartemisinin-1,2-a-succinic acid monoester, and the molecular formula is C 19 o 8 h 28 , molecular weight 384.43, white powder, odorless, almost tasteless, easily soluble in acetone, chloroform, soluble in ethanol or ethyl acetate, almost insoluble in water, melting point 130---137. Artesunate mainly acts on the erythrocytic clones of Plasmodium, and is currently the only effective derivative of artemisinin that can be made into water-soluble preparations. It is used for the treatment of various malaria, especially multidrug-resistant falciparum malaria. It also has anti-pregnancy, anti-fibrosis, anti-schistosome, anti-toxoplasma, anti-arrhythmia and tumor cytotoxic effects. [0003] The main problems of artemisinin and ...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K31/357A61K47/42A61P33/06
Inventor 洪宗国
Owner SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES
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