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Medicinal composition for treating ophthalmic inflammation and application thereof

A technology of composition and traditional Chinese medicine, which is applied in the direction of drug combination, active ingredients of boron compounds, active ingredients of hydroxyl compounds, etc., can solve the problems of unclear active ingredient groups of collagen, infeasibility, unclear collagen process parameters, etc.

Inactive Publication Date: 2010-02-17
BEIJING HERUN INNOVATION PHARMA TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the patent application for collagen eye drops (publication number CN1927391A), the collagen used has no clear active ingredient group, and the process parameters are not clear when preparing collagen, which leads to unclear effective parts. ; Adopt pepsin or papain to carry out enzymolysis in this patent application, because pepsin enzymolysis specific limitation, it can not enzymolyze the proline peptide bond in the collagen, that is to say that pepsin can't enzymatically decompose collagen into Collagen, so the collagen described in this patent application is not collagen in the actual sense (relative molecular weight is not higher than 100kD), so this patent application is not feasible; in the patent application for composite collagen eye drops ( Publication No. CN1927392A) added chemical medicine antibiotics to be used in combination with collagen, but it is limited to the application of chemical medicine, and it is not reproducible for traditional Chinese medicine with complex components, and the patent also does not specify the active ingredient group of collagen , confusing the concept of collagen and collagen
It can be seen that the prior art does not really solve the technical problems of collagen or collagen in ophthalmic medicine, especially the situation of combining collagen or collagen with traditional Chinese medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] Prescription: 5g of bear bile powder, 100ml of collagen extract (containing 2.5g of collagen)

[0091] Preparation method: Take bear bile powder, add 100ml of water for injection, heat to boil to dissolve, let cool, add ethanol to make the alcohol content reach 75%, let it stand for 24 hours, filter, and recover the ethanol from the filtrate under reduced pressure until it has no alcohol smell, and set aside Take 600ml of water for injection, add 12g of boric acid, 0.6g of borax, and 0.8g of ethylparaben, stir until clarified, heat to 70°C, filter, add the above-mentioned bear bile aqueous solution under stirring, and then add collagen extract, Add water for injection to 1000g, pass through a microporous membrane (0.22μm), and aseptically dispense to obtain the product. (Note: The collagen used is gelatin biomimetic hydrolysis with pepsin and trypsin, and then obtained by ultrafiltration with a 5kD ultrafiltration membrane)

Embodiment 2

[0093] Prescription: Curcuma 1000g, Collagen Extract 200ml (Containing Collagen 5g), Sodium Hyaluronate 1.4g

[0094] Preparation method: take curcuma medicinal material, steam distillation to extract volatile oil, separate volatile oil, take 4g, add 15g polysorbate 80, grind well, and set aside; take 1600ml water for injection, add gellan gum, stir evenly, put in boiling water bath, stir Until clarification, add 24g of boric acid, 1.2g of borax, and 1.2g of ethylparaben, heat to 70°C, stir until clarification, filter, add the above-mentioned curcuma oil while stirring, then add collagen extract, add water for injection to 2000g , add sodium hyaluronate, fully swell, stir evenly, pass through a microporous membrane (0.22 μm), and aseptically dispense to obtain. (Note: The collagen used is obtained from pigskin after enzymatic hydrolysis with neutral protease, and then ultrafiltration through a 10kD ultrafiltration membrane)

Embodiment 3

[0096] Prescription: Pueraria 2000g, aloe vera gel 20g, borneol 1g

[0097] Collagen extract 120ml (contains collagen 3g)

[0098] Preparation method: Take Pueraria root, add 8 times the amount of water to decoct twice, each time for 2 hours, filter, combine the filtrate, concentrate under reduced pressure, add ethanol to make the alcohol content reach 70%, let it stand overnight, take the supernatant to reduce Recover ethanol under pressure, put the remaining water on the AB-8 macroporous adsorption resin column, elute with water and ethanol respectively, collect the ethanol eluate, recover the ethanol under reduced pressure until there is no alcohol smell, and use the water for later use; take another phenoxyethanol to add Add 1000ml of water for injection that has been heated to about 80°C, stir well, add 24g of boric acid and 1.2g of borax while it is hot, stir to dissolve, let it cool, add it to the kudzu root extract, stir well, slowly add aloe vera gel, ethanol C...

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PUM

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Abstract

The invention discloses a Chinese medicinal composition for treating ophthalmic inflammation, which consists of collagen and Chinese medicaments for clearing heat and diminishing inflammation, and belongs to the field of Chinese medicament. Raw material medicaments of effective components of the Chinese medicinal composition comprise collagen and Chinese medicaments for clearing heat and diminishing inflammation such as bear bile powder, pig bile, wild chrysanthemum and the like which are prepared into various eye preparations by combining the prior art. The technical scheme creatively combines and applies the collagen and the effective components of the Chinese medicaments in the eye preparations so as to enlarge the application range of the collagen and achieve remarkable effect in the aspect of treating various ophthalmic inflammations.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating ophthalmic inflammation, which is composed of collagen and traditional Chinese medicines for clearing away heat and reducing inflammation, and belongs to the field of traditional Chinese medicines. Background technique [0002] Ophthalmic inflammation accounts for a relatively large proportion of ophthalmic diseases. At present, conjunctivitis, keratitis, trachoma, blepharitis, blepharitis, scleritis, lacrimal gland inflammation, dacryocystitis and corneal ulcer are common clinically. . Ophthalmic inflammatory lesions have brought great suffering to the majority of patients. Chinese medicine has its own unique features in the treatment of these diseases under the same conditions. The theory of nature and flavor of traditional Chinese medicine highly summarizes the general law of drug efficacy, and successfully guides the clinical practice of prescriptions and medications ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K38/39A61P27/02A61K36/906A61K36/744A61K36/634A61K36/539A61K36/28A61K36/56A61K36/534A61K33/22A61K35/56A61K35/55A61K31/045A61K35/32A61K35/413A61K33/30
Inventor 朴美善王广录
Owner BEIJING HERUN INNOVATION PHARMA TECH DEV
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