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Glyceryl guaiacolate and pseudoephedrine compound sustained release preparation

A technology of guaiacol glyceryl ether and pseudoephedrine, which is applied in the field of medicine and achieves the effects of small fluctuation, less medication frequency and reduced medication frequency.

Active Publication Date: 2010-03-03
北京科信聚润医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there is no specific treatment at all, it is not necessary for the virus to be firm, and only symptomatic treatment can be used to relieve many symptoms of the common cold

Method used

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  • Glyceryl guaiacolate and pseudoephedrine compound sustained release preparation
  • Glyceryl guaiacolate and pseudoephedrine compound sustained release preparation
  • Glyceryl guaiacolate and pseudoephedrine compound sustained release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] prescription:

[0028] Guaifenesin

800g

Pseudoephedrine Hydrochloride

90g

Hypromellose E5

40g

carnauba wax

25g

microcrystalline cellulose

36g

Povidone K 30 aqueous solution

Appropriate amount

Magnesium stearate

Appropriate amount

[0029] Coating prescription:

[0030] Opadry

15g

pure water

Add to 100ml

[0031] Preparation:

[0032] (1) Preparation of granules Hypromellose E5 and microcrystalline cellulose were sieved respectively, mixed evenly with guaiacol glyceryl ether, pseudoephedrine hydrochloride and carnauba wax, and mixed with 5% povidone K 30 The aqueous solution is a soft material made of adhesive, wet granules are prepared through a 20-mesh sieve, dried at 60°C, granulated through a 20-mesh sieve, and set aside.

[0033] (2) Preparation of coating liquid Add Opadry to pure water, and add pure water to 100ml, stir for 1 hour, ...

Embodiment 2

[0043] prescription:

[0044] Guaifenesin

400g

Pseudoephedrine Hydrochloride

60g

Hypromellose K100

6g

Hypromellose E5

75g

[0045] microcrystalline cellulose

45g

Povidone K 30 aqueous solution

Appropriate amount

stearic acid

Appropriate amount

[0046] Coating prescription:

[0047] Pseudoephedrine Hydrochloride

30g

Opadry

25g

water

Appropriate amount until completely dissolved

[0048] Preparation:

[0049] (1) Preparation of granules Hypromellose and microcrystalline cellulose are sieved respectively, mixed and evenly mixed, then mixed evenly with guaiacol glyceryl ether and pseudoephedrine hydrochloride, and mixed with 8% povidone K 30 The aqueous solution is a soft material made of adhesive, wet granules are prepared through a 20-mesh sieve, dried at 60°C, granulated through a 20-mesh sieve, and set aside.

[0050] (2) ...

Embodiment 3

[0060] prescription:

[0061] Guaifenesin

600g

pseudoephedrine sulfate

60g

pregelatinized starch

110g

Sodium carboxymethyl starch

20g

Hypromellose K4

7g

Hydroxyethyl cellulose

72g

microcrystalline cellulose

60g

carnauba wax

50g

Povidone K 30 aqueous solution

Appropriate amount

Talc powder

20g

[0062] Coating prescription:

[0063] Opadry II

30g

pure water

1000ml

[0064] Preparation:

[0065] (1) Each component in the prescription is passed through a 100-mesh sieve respectively, and set aside;

[0066] (2) Preparation of immediate-release granules: Fully mix the prescription amount of pregelatinized starch and 1 / 2 amount of sodium carboxymethyl starch, mix evenly with guaiacol glyceryl ether, and mix with 5% povidone K 30 The aqueous solution is a soft material made of adhesive, 20-mesh sieve is used ...

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PUM

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Abstract

The invention relates to a sustained release preparation taking glyceryl guaiacolate and pseudoephedrine or physiologically acceptable salts thereof as active components, and provides a compound preparation which can overcome cold related symptoms and of which all the active components are slowly released.

Description

technical field [0001] The invention relates to a sustained-release preparation with guaiacol glycerin, pseudoephedrine or a physiologically acceptable salt thereof as active components, and belongs to the field of medicine. Background technique [0002] A cold is an infection of the upper respiratory tract mucosa caused by many different types of viruses. The main symptoms are nasal congestion, sneezing, mild sore throat, and fever. Systemic symptoms include general discomfort, headache, and myalgia. Because there is no specific treatment at all, it is not necessary to make the virus firm, and only symptomatic treatment can be used to promote the relief of many symptoms of the cold. Since there is still no one drug to alleviate the coexisting symptoms, various compound preparations have been listed one after another. These compound preparations are composed of drugs with different curative effects to relieve different symptoms that exist at the same time. If the patient h...

Claims

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Application Information

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IPC IPC(8): A61K9/28A61K31/09A61K31/137A61P11/00A61P31/12
Inventor 郑顺利
Owner 北京科信聚润医药科技有限公司
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