Valnemulin for livestock and saline premix and preparation method thereof

A technology of vonimulin and premix, which is applied to non-active ingredients in medical preparations, pharmaceutical formulations, antibacterial drugs, etc., can solve the problems of affecting animal feeding, adverse treatment effects, and increasing the number of administrations, etc. Achieve the effect of improving palatability, ensuring dosage, and prolonging action time

Active Publication Date: 2013-03-06
BEIJING DABEINONG ANIMAL HEALTH TECH
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Vernimulin is easily hydrolyzed, sensitive to temperature, and poor in stability
At present, wernemulin is mainly administered orally, but the raw material of wernemulin has a strong smell and is easy to scatter, which makes it poor in palatability and affects animal feed intake, and because of its fast excretion, it is necessary to increase the number of administrations. Facilitate effective treatment

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Valnemulin for livestock and saline premix and preparation method thereof
  • Valnemulin for livestock and saline premix and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation of embodiment 1 warnemulin sustained-release pellets

[0030] prescription:

[0031] prescription ingredients

Dosage of 1000g microspheres (g)

weight percentage (%)

Warney Millennium

800

80

starch

50

5

Sucrose (80 mesh)

30

3

PVPk30

100

100

Ethyl cellulose

20

2

[0032] Preparation Process:

[0033] 1) Add varnemulin, starch, and sucrose into the fluidized bed, and blow in air to make the materials mix evenly in a fluidized state;

[0034] 2) Dissolve PVPk30 in ethanol to make a 30% solution. Spray the solution into the coating column, control the inlet temperature to 60°C, the spray pressure to 0.5MPa, and the spray speed to 100ml / min. After the spraying is over, wernemulin pellets are obtained;

[0035] 3) dissolving ethyl cellulose in ethanol to prepare a coating solution with a concentration of 30%. Spray the coating solution in...

Embodiment 2

[0037] The preparation of embodiment 2 warnemulin hydrochloride ordinary pellets

[0038] prescription:

[0039] prescription ingredients

Dosage of 1000g microspheres (g)

weight percentage (%)

Warnemulin Hydrochloride

900

90

PVP k30

80

80

Hydroxypropyl Cellulose

20

2

[0040] Preparation Process:

[0041] 1) adding warnemulin hydrochloride into a high-speed stirring granulator, spraying into 30% PVP k30 ethanol solution, rotating and stirring at a high speed to granulate;

[0042] 2) drying the prepared wet granules at 60°C;

[0043] 3) Put the dried granules in a coating pan, spray into 30% hydroxypropyl methylcellulose aqueous solution for coating;

[0044] 4) Sieve to collect pellets with a size of 10-50 mesh.

Embodiment 3

[0045] The preparation of embodiment 3 warnimulin ordinary pellets

[0046] prescription:

[0047] prescription ingredients

Dosage of 1000g microspheres (g)

weight percentage (%)

Warney Millennium

800

80

starch

50

5

Lactose (80 mesh)

30

3

Sodium dodecyl sulfate

20

2

PVPk30

100

10

[0048] Preparation Process:

[0049] 1) Add warnemulin, starch, lactose, and sodium lauryl sulfate into the fluidized bed, and blow in air to make the materials mix evenly in a fluidized state;

[0050] 2) Spray 300ml of 30% PVP k30 ethanol solution into the coating column, control the air inlet temperature to be 40°C, the spray pressure to be 0.5MPa, and the spray speed to be 100ml / min, and then sprayed in for granulation;

[0051] 3) Spray the remaining 30% ethanol solution of PVP k30 for coating, the air inlet temperature is 50°C, the spray pressure is 0.5MPa, and the spray s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a valnemulin for livestock and saline premix and a preparation method thereof, belonging to the field of antibiotics for livestock; the preparation contains valnemulin common pellets and / or slow-release pellets, and premix ground substances such as amylum and bran oil can be added in the preparation for being prepared into premix with different concentration. The valnemulin and the saline premix in the invention contain two kinds of pellets with different drug release rate, so as to have quick-acting and long-acting effect; furthermore, the valnemulin and the saline pellets have the advantages of damp-proofing and harmful environment isolation; unpleasant odor of the drug is covered, and the compliance of the livestock to the drug is increased; the valnemulin and the saline premix have smooth surface and good mobility and are easy to carry out dose administration by mixing with the fodder.

Description

technical field [0001] The invention belongs to the field of veterinary antibiotic preparations, and relates to a premix of warnemulin and its salt and a preparation method thereof. Background technique [0002] Valnemulin and its salts are a new bag of pleuromutilin semi-synthetic antibiotics, which belong to diterpenes and belong to the same class of drugs as tiamulin. They are animal-specific antibiotics and are mainly used to prevent and treat pigs, Mycoplasmosis and Gram-positive bacterial infections in cattle, sheep and poultry. In 1999, it was approved by the European Community for the prevention and treatment of swine dysentery caused by Brachyspira hyodysenteriae infection and swine enzootic pneumonia caused by Mycoplasma pneumoniae infection. It is the first veterinary drug premix approved in Europe. Classified as a prescription drug for veterinary use. [0003] Wonimulin absorbs quickly in the body, and the part is extensive, and the bioavailability is high. Ve...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/22A61K47/38A61K47/32A61P31/00A61P31/04
Inventor 田玲刘澜周德刚莫云葛冰王海良张俊儒葛代兴邓利斌黄建茹丛日刚庞加春布仁阿古达木
Owner BEIJING DABEINONG ANIMAL HEALTH TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap