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a drug for diabetes

A technology for diabetes and drugs, applied in the field of drugs for the treatment of diabetes, to achieve the effect of enhancing insulin sensitivity, simple process, and reducing fasting and postprandial blood sugar

Inactive Publication Date: 2011-11-30
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there are various side effects of the above-mentioned drugs, so the market still needs new anti-diabetic drugs with new uses and mechanisms

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, the preparation of the medicine for the treatment of diabetes

[0027] With 1 mass part of scorpion crude drug (Shenzhen Lifeng Pharmaceutical Co., Ltd., batch number 20090314) and 10 mass parts of gypsum crude drug (the main component is CaSO 4 2H 2 O, Shenzhen Lifeng Pharmaceutical Co., Ltd., batch number 20090118) prepares the medicine for the treatment of diabetes (the above Chinese herbal medicines have all reached the corresponding quality control detection standard established by the 2005 edition of the Pharmacopoeia of the People's Republic of China (Part One)), the steps are as follows:

[0028] 1. Dry the scorpion at 60°C for 24 hours, crush it, and pass it through a 100-mesh sieve to get the scorpion powder;

[0029] 2. Add 5 times the weight of distilled water to the gypsum, bathe in 95°C water for 1 hour, and filter with cotton or gauze to obtain the gypsum water extract (suspension);

[0030] 3. The scorpion powder and the water extract of ...

Embodiment 2

[0031] Embodiment 2, the drug effect of the medicine for the treatment of diabetes

[0032] 1. Production of NIH mouse diabetes model

[0033] NIH male mice (about 20 g) were fasted for 24 hours, and injected intraperitoneally once with 100 mg / kg streptozotocin (Streptozotocin, Sigma Company, USA) (streptozotocin was freshly prepared with ice-bathed citrate buffer solution in advance). reconstituted (0.1M, pH 4.5), injected within 5 minutes). After 10 days, the mice with a stable increase in blood sugar (blood sugar above 11.1 mmol / L) were the NIH mouse diabetes models.

[0034] 2. Administration of NIH mouse diabetes model

[0035] Administration group A (scorpion treatment group; D+S): NIH mouse diabetes model; the scorpion powder of step 1 of Example 1; 350mg scorpion powder / kg mouse / day;

[0036] Administration group B (gypsum treatment group; D+G): NIH mouse diabetes model; the water extract of gypsum in step 2 of Example 1; the water extract of 3.5g gypsum / kg mouse / day;...

Embodiment 3

[0070] Embodiment 3, the glucose tolerance experiment of mice after administration

[0071] 1. Oral glucose tolerance

[0072] 1. Production of NIH mouse diabetes model

[0073] Same as Step 1 of Example 2.

[0074] 2. Administration of NIH mouse diabetes model

[0075] Scorpion+gypsum treatment group (D+SG): NIH mouse diabetes model; the medicine for treating diabetes in the step 3 of embodiment 1; (the medicine obtained by mixing the water extract of 350mg scorpion powder and 3.5g gypsum) / kg mouse / day;

[0076] Metformin group (D+M): NIH mouse diabetes model; Metformin (Tianjin Pacific Pharmaceutical Technology Group, production batch number 071101); 250mg metformin / kg mouse / day;

[0077] Normal group (N): normal NIH male mice; double distilled water;

[0078] Diabetic control group (D): NIH mouse diabetes model; double distilled water;

[0079]In the above administration groups, the drug was suspended in equal volume of double distilled water before use, and administ...

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Abstract

The invention discloses a medicament for treating diabetes. Active components of the medicament for treating the diabetes are prepared from the following raw materials in part by weight: 0.5 to 2 parts of scorpion and 8 to 12 parts of gypsum. The medicament is a natural and simple Chinese medicinal compound preparation, which combines animal and mineral medicaments in traditional Chinese medicaments for preventing and treating the diabetes progressively increased for the first time. The medicament has the effects of strengthening insulin sensitivity, reducing fasting and postprandial blood glucose, regulating lipid disturbance caused by the diabetes and the like, and has the action mechanism of mainly promoting the recovery of pancreas islet function. The scorpion dosage in the medicament is the common safe dosage, and obvious toxic or side effects are not found in the usability process. The medicament is unique in curative effect, clear in mechanism and simple in process and is suitable for industrialization and international markets.

Description

technical field [0001] The invention relates to a medicine for treating diabetes. Background technique [0002] Diabetes is a chronic metabolic disorder and has become the third major non-communicable disease after cardiovascular and cerebrovascular diseases and tumors, accounting for about 5% of the total population. Diabetes is mainly divided into type 1 diabetes and type 2 diabetes, of which type 2 diabetes accounts for more than 90%. Type 1 diabetes mainly manifests as defects in islet function, decreased or lacking insulin levels, severe hyperglycemia, weight loss, sugar in urine, increased appetite, and the need for insulin supplementation to maintain normal blood sugar, also known as insulin-dependent diabetes. In the early stage of type 2 diabetes, the main manifestations are insulin resistance, increased, unchanged or decreased insulin levels, relative lack of insulin, elevated blood sugar and other symptoms. In patients with advanced type 2 diabetes, the pancreat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61P3/10A61K33/06A61K35/646
Inventor 谢伟东张雅鸥
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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