Porous bone replacing material and preparation method thereof

Abstract

The invention provides an antibiotic controlled freed porous bone replacing material and a preparation method thereof. The antibiotic controlled freed porous bone replacing material is characterized by consisting of polycaprolactone, nano tricalcium phosphate, chitosan/vancomycin microsphere with sodium alginate coating, and tobramycin. The preparation method comprises the following steps: dissolving the chitosan in glacial acetic acid solution, dissolving the vancomycin in the glacial acetic acid solution, spraying and drying to prepare the chitosan/vancomycin microsphere; moving the microsphere into the sodium alginate solution; dissolving the microsphere and the nano tricalcium phosphate powder in dichloromethane solution of the polycaprolactone, adding a pore-forming agent, stirring uniformly, extruding and forming, putting the formed material in deionized water after the dichloromethane is volatilized, dissolving out the pore-forming agent, and obtaining the porous material; and immersing the porous material into tobramycin sulfate solution, and drying. The invention has the advantages that the vancomycin and the tobramycin can be released simultaneously in the early stage. The two antibiotics can kill the intractable bacteria of methicillin-resistant Staphylococcus aureus and the like, which are common clinically and infected chronically by bones.

Description

technical field [0001] The invention relates to a porous bone substitute material and a preparation method thereof, which are used for treating various bacteria, especially infectious bone defects combined with methicillin-resistant Staphylococcus aureus (MRSA), and filling treatment for chronic osteomyelitis. Background technique [0002] At present, the only way to clear the bacteria that cause bone infection is to increase the local concentration of antibiotics in the infected tissue to exert effective antibacterial activity. Scientists have tried many local drug delivery systems, such as antibiotic-loaded acrylic bone cement, polymethylmethacrylate Bead chain, hydroxyapatite (HAp), etc. Shinto et al. first used porous hydroxyapatite as a drug sustained release system, and obtained good results in animal experiments. [0003] Some artificial bone materials currently on the market are either not sensitive to the antibacterial spectrum of antibiotics, or their materials ar...

AI Technical Summary

Problems solved by technology

Michael et al. have used the nano-HAp material as the carrier of vancomycin, but their method is to make the material into particles first, and then immerse it in the aqueous solution of vancomycin to prepare it, but the disadvantage of this method is that the carrier The dose is unstable, and the slow release of the drug cannot be controlled, and the drug content of the granules gradually decreases from the surface to the inside, which is not conducive to maintaining a continuous antibacterial effect

[0006] Tobramycin-containing Ca 2 SO 4 Although artificial bone is widely used in clinical practice, its degradation rate is too fast, and sometimes it is difficult to maintain a sustained antibacterial concentration. Moreover, none of the above-mentioned products are constructed of porous materials, which are conducive to the growth of osteoblasts and the implantation of artificial bones. The reabsorption of materials promotes the repair of bone defects.

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