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Application of quinolones anti-bacterial medicines to curing psoriasis

A technology for psoriasis and drugs, applied in the application field of quinolone antibacterial drugs in the treatment of psoriasis, can solve the problems of ineffective treatment, toxic and side effects, and inability to achieve cure, and achieve high cure rate, small toxic and side effects, and control Effects of Psoriasis Conditions

Inactive Publication Date: 2012-04-04
王国礼
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Polat et al. believe that macrolide antibiotics are effective in the treatment of psoriasis vulgaris, while others believe that penicillin antibiotics are ineffective in the treatment of such diseases
In addition, commonly used clinical treatment options for psoriasis include topical medication, photochemotherapy, systemic therapy, etc., but there are still many problems in various treatment methods that cannot achieve the goal of cure
Vitamin D analogues and corticosteroids are the main topical medications, which have the disadvantages of temporary relief of symptoms and reduced curative effect of continuous medication
Photochemotherapy can be used for patients with poor local treatment effect. The short-term side effects of this method are mainly phototoxicity reactions, and the long-term side effects include accelerated skin aging, eye damage, carcinogenesis, etc.
Systemic drugs such as methotrexate, cyclosporine, acitretin, and fumaric acid are only used for local treatment or when phototherapy cannot be controlled, but these drugs often have potentially serious side effects

Method used

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  • Application of quinolones anti-bacterial medicines to curing psoriasis
  • Application of quinolones anti-bacterial medicines to curing psoriasis
  • Application of quinolones anti-bacterial medicines to curing psoriasis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Name: Zhou ×× Gender: Female Age: 30 years old. History of present illness: erythema and scales all over the body for 12 years. Physical examination: Scattered erythema and silvery white scales were seen on the face and extremities, and erythema the size of rice grains to bean grains was seen on the trunk. Treatment plan: the first course of treatment: Ciprofloxacin tablets 0.5gtidpo for 1 week, vitamin B complex tablets 3 tablets tidpo for 2 weeks, the second course of treatment: Amikacin injection 0.4givdripqd for 10 days. Disease outcome: After treatment, the skin lesions completely subsided. figure 1 A photo of the affected skin of the patient before treatment, figure 2 A photograph of the same skin area two weeks after dosing the patient.

Embodiment 2

[0028] Name: Li × Gender: Male Age: 37 years old, history of present illness: red papules all over the body, desquamation and itching for 1 month. One month ago, after upper respiratory tract infection, local red papules appeared on the right lower extremity, which gradually increased. After external application of "perisone, tazarotene gel, and narrow-band UVB irradiation for 5 times", there was no obvious improvement. Physical examination: mung bean-sized red papules scattered on the face, neck, trunk, and limbs, partly covered with white scales. Treatment plan: the first course of treatment: Ciprofloxacin 0.5g tid po for 2 weeks. Vitamin B complex tablets 2 tidpo 2 weeks. The second course of treatment: 1 week as above; the third course of treatment: Amikacin injection 0.4givdripqd for 1 week. Outcome of the disease: the skin lesions subsided, and there was no recurrence after 2 months of drug withdrawal. attached image 3 A photo of the skin of the patient's affected are...

Embodiment 3

[0030] Name: Zhang ×× Gender: Male Age: 37 years old, history of present illness: erythema and desquamation on the trunk and limbs for 1 week. One week ago, erythema and desquamation appeared on the trunk, and then spread all over the body. There were no obvious subjective symptoms, no fever, and no joint pain. Examination: The trunk and proximal extremities are densely covered with bean macula and papules, with clear boundaries and a little desquamation, which is easy to scrape off, and thin film phenomenon and spotting hemorrhage can be seen. Pharynx was not congested. Treatment plan: first course of treatment: amikacin injection 0.4givdripqd for 1 week; second course of treatment: ciprofloxacin 0.5gtidpo for 2 weeks. Outcome of the disease: the skin lesions disappeared completely, and there was no recurrence for 5 months, and no recurrence for 6 months after the cure. attached Figure 5 A photo of the skin of the patient's affected area before treatment, with Figure...

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Abstract

The invention relates to quinolones anti-bacterial medicines, in particular to pharmaceutical composition and application thereof to preparing medicines for treatment of psoriasis. The invention is characterized in that the quinolones anti-bacterial medicines are applied to treat the psoriasis by ways of intravenous and muscle injection, oral, aerosol inhalation and dissolving in mouth for administration, and the quinolones anti-bacterial medicines are applied to prepare the pharmaceutical composition for treating the psoriasis. According to a treatment mechanism of the quinolones anti-bacterial medicines which can take deoxynucleotide of bacteria as a target object and have a targeted bactericidal effect on the main inducement- cell wall defect bacteria of the psoriasis, the invention realizes controlling the illness state of the psoriasis effectively and achieving a cure purpose finally, and has the advantages of high cure rate, little toxic and side effect, safety and reliability, and the like.

Description

technical field [0001] The invention relates to quinolone antibacterial drugs, in particular to the application of quinolone antibacterial drugs in the treatment of psoriasis. Background technique [0002] Psoriasis is a chronic proliferative skin disease with an incidence rate of 1%-3% in the population. The disease has a long course and can invade multiple organs. It has become one of the key research diseases in the field of dermatology. The clinical types of psoriasis mainly include four types: vulgaris, pustular, erythrodermic, and arthropathy. Psoriasis vulgaris is the most common type, accounting for more than 90%. [0003] The etiology and treatment of psoriasis are still unclear. Many studies have shown that psoriasis can be induced or aggravated by various biological factors, among which the more important theory is the relationship between streptococcus and guttate psoriasis vulgaris and chronic plaque psoriasis. This theory holds that psoriasis is a kind of st...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K31/7036A61P17/06
Inventor 王国礼
Owner 王国礼
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