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Preparation method of acanthopanax effervescent tablet and products thereof

A kind of Acanthopanax and effervescent tablet technology, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of poor stability of preparations, poor foaming effect, and easy sticking, etc. problem, to achieve the effect of reducing moisture absorption, strong operability and increasing stability

Inactive Publication Date: 2010-06-23
HARBIN RENHUANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] According to this process, the main disadvantage of the preparation of Acanthopanax effervescent tablets is that the alkaline effervescent sodium carbonate in the formula is in direct contact with the acidic substances in the formula, which makes the stability of the preparation poor, the foaming effect is poor, and it is easy to stick when tableting rush

Method used

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  • Preparation method of acanthopanax effervescent tablet and products thereof
  • Preparation method of acanthopanax effervescent tablet and products thereof
  • Preparation method of acanthopanax effervescent tablet and products thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Weigh 300g of Acanthopanax extractum, 150g of lactose, 485g of citric acid, 730g of sodium bicarbonate, 65g of polyethylene glycol 4000, 100g of fumaric acid, and 60g of cyclamate;

[0041] According to the process described in Test Example 1, the Acanthopanax saponiosa extract and lactose were mixed evenly, dried, pulverized into fine powder, and set aside; measure 500ml of ethanol solution to dissolve polyethylene glycol 4000, and add sodium bicarbonate to polyethylene glycol Wrap it in the solution to obtain a mixed solution containing inclusions, spray it into a rotating coating pan filled with Acanthopanax extractum and lactose mixed fine powder, sieve, and granulate to obtain granules for later use; Sieve citric acid and cyclamate to make granules, mix with the above granules and fumaric acid fine powder, and press 1000 tablets (1.8g / tablet). All the inspection indexes of the prepared granules are in compliance with the regulations, and the accelerated test has be...

Embodiment 2

[0043] Weigh 300g of Acanthopanax extirgae extract, 175g of lactose, 370g of citric acid, 555g of sodium bicarbonate, 60g of polyethylene glycol 4000, 80g of fumaric acid, and 50g of cyclamate;

[0044] According to the process described in Test Example 1, mix Acanthopanax saponiosa extract and lactose evenly, dry, pulverize into fine powder, and set aside; measure 400ml of ethanol solution to dissolve polyethylene glycol 4000, and add sodium bicarbonate to the polyethylene glycol solution Wrap it up to obtain a mixed solution containing inclusions, spray it in a rotary coating pan filled with Acanthopanax extractum and lactose mixed fine powder, sieve, and granulate to obtain granules for later use; Citric acid and cyclamate were sieved to make granules, mixed with the above granules and fumaric acid fine powder, and pressed into 1000 tablets (1.5g / tablet). All the inspection indexes of the prepared granules are in compliance with the regulations, and the accelerated test has...

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Abstract

The invention discloses a preparation method of acanthopanax effervescent tablet, which comprises the following steps of: (1) evenly mixing the acanthopanax extract with the lactose, drying and crashing to fine powder for later use; (2) wrapping the sodium bicarbonate with the polyethyleneglycol 4000 to obtain a mixed solution containing the inclusion; (3) spraying the mixed solution containing the inclusion in a rotation coating pan filled with the powder obtained in the step (1), screening and granulating to obtain the grains; and (4) screening the citric acid and the sodium cyclamate to obtain the grains, mixing with the grains prepared in the step (3) and the boletic acid powder and tabletting to prepare the finished product. In the preparation method, the sodium bicarbonate is wrapped by the polyethyleneglycol 4000 to avoid the direct contact of the sodium bicarbonate with the acid, thereby the stability of the preparation is enhanced, and the sticking problem when tabletting is solved. In addition, in the method of the invention, the lactose and the sodium cyclamate are utilized to replace the cane sugar for filling so that the moisture absorption is reduced. The preparation method has the advantages of simpleness, security, stability and high operability.

Description

technical field [0001] The invention relates to a method for preparing effervescent tablets, in particular to a method for preparing Acanthopanax effervescent tablets and an Acanthopanax effervescent tablet product prepared by the method, belonging to the field of Acanthopanax medicaments. Background technique [0002] A large number of clinical studies have proved that Acanthopanax has the functions of regulating the central nervous system, improving sleep quality, improving heart and brain blood circulation, regulating the endocrine system, and improving human immunity. Its extensive medicinal value and health care value determine its important clinical application value and economic value. Therefore, the development of Acanthopanax preparations with good curative effect, convenient administration and stable process meets the development requirements of the industry. [0003] Existing Acanthopanax effervescent tablets (Acanthopanax nutrient effervescent slices) are made by...

Claims

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Application Information

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IPC IPC(8): A61K36/254A61K9/46A61K47/34A61P25/20A61P9/00A61P5/00A61P37/04A61K47/10A61K47/26
Inventor 孙玉艳崔玉海
Owner HARBIN RENHUANG PHARMA
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