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Lamiophlomis rotata traditional Chinese medicine and preparation method thereof

A unique and crude drug technology, applied in drug combinations, pharmaceutical formulations, antipyretics, etc., can solve the problems of affecting the quality and efficacy of drugs, low bioavailability, and large doses of drugs, to increase the transdermal speed and transdermal Amount, good therapeutic effect, high ratio of active ingredients

Inactive Publication Date: 2010-06-23
唐良平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because it needs to go through the first-pass effect of the liver when used as an oral preparation, its onset is slow, and it cannot reach a certain blood concentration in a short period of time. The bioavailability is low and the dosage is large, which directly affects the quality and curative effect of the drug. And there are certain toxic side effects

Method used

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  • Lamiophlomis rotata traditional Chinese medicine and preparation method thereof
  • Lamiophlomis rotata traditional Chinese medicine and preparation method thereof
  • Lamiophlomis rotata traditional Chinese medicine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0090] raw material:

[0091] Unique herbs 800g, menthol 20g, borneol 30g

[0092] Camphor 20g Wintergreen Oil 20g Azone 3g

[0093] Citral 2g Natural Rubber 400g Zinc Oxide 520g

[0094] Rosin 400g Lanolin 44g Vaseline 50g

[0095]

[0096] A total of 1000 pieces were made

[0097] Preparation:

[0098] 1. Take the unique medicinal material and crush it into a coarse powder, add 80% ethanol and 8000ml of reflux to extract 3 times, each time for 1.5 hours, combine the extracts, filter, recover the ethanol from the filtrate, concentrate it to 2 times the amount of the crude drug, and separate it with a macroporous resin , collect the active ingredients, and then concentrate under reduced pressure to a relative density of 1.3 to 1.35 (60°C) to prepare the Duyiwei thick ointment extract for later use.

[0099] 2. Soak and swell natural rubber with solvent oil, add zinc oxide, rosin, ...

Embodiment 2

[0102] raw material:

[0103] Unique herbs 800g, menthol 20g, borneol 45g

[0104] Camphor 20g Wintergreen Oil 50g Azone 3g

[0105] Citral 3g Natural Rubber 340g Styrene Butadiene Rubber 85g

[0106] Petroleum resin 420g Lithopone 480g Lanolin 56g

[0107] Vaseline 30g

[0108]

[0109] A total of 1000 pieces were made

[0110] Preparation method one (solvent method):

[0111] 1. Take the unique medicinal material and crush it into a coarse powder, add 90% ethanol, 9000ml reflux extraction for 3 times, the first time is 2.0 hours, the second and third time are 1.5 hours, combine the extracts, filter, recover the ethanol from the filtrate, concentrate to the crude drug amount When the time is 2 times, use macroporous resin to separate, collect active ingredients, and then concentrate under reduced pressure to a relative density of 1.3-1.35 (55°C) for later use.

[0112]...

Embodiment 3

[0119] prescription:

[0120] Unique herbs 800g, menthol 20g, borneol 50g

[0121] Camphor 20g Wintergreen Oil 40g Azone 3g

[0122] Citral 3g SIS 400g SBS 50g

[0123] 425g petroleum resin, 387g calcium carbonate, 400g paraffin oil

[0124]

[0125] A total of 1000 pieces were made

[0126] Preparation:

[0127] 1. Take the unique medicinal material and crush it into a coarse powder, add 85% ethanol, 6000ml reflux extraction 3 times, each time for 1.5 hours, combine the extracts, filter, recover the ethanol from the filtrate, concentrate to 1-5 times the crude drug amount, use large Pore ​​resin is separated, the active ingredients are collected, and then concentrated under reduced pressure to a relative density of 1.3-1.35 (50°C) for later use.

[0128] 2. Mix and heat SIS, SBS and naphthenic oil to melt and mix well, then add petroleum resin and calcium carbonate in s...

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Abstract

The invention relates to a lamiophlomis rotata externally-applied preparation which adopts raw materials comprising a lamiophlomis rotata thick paste and an externally-applied substrate, wherein the externally-applied substrate comprises a framework material and auxiliary materials, and the framework material is a high molecular material, such as natural rubber, or mixed rubber comprising natural rubber and styrene-butadiene rubber, or a thermoplastic high molecular material; the preparation method of the lamiophlomis rotata externally-applied preparation comprises the following steps: firstly, extracting, purifying and concentrating the crude drug of lamiophlomis rotata to prepare the lamiophlomis rotata thick paste and then adding other raw materials to prepare a lamiophlomis rotata rubber ointment, wherein, macroporous resin is used for carrying out purifying. In the raw materials, menthol, wintergreen oil, borneol, camphor and the lamiophlomis rotata are matched and used according to the specific proportion of the invention, which changes the microstructure of the skin, increases the percutaneous speed and the percutaneous quantity of the medicine, improves the blood circulation and enhances the release degree of the active components of the medicine in the ointment; the effective components of the lamiophlomis rotata thick paste prepared by refluxing and extracting through adopting an ethanol solution have high proportion and high purity, so that the lamiophlomis rotata externally-applied preparation has high medicine effect and also has good stability.

Description

technical field [0001] The present invention relates to unique traditional Chinese medicine, in particular to unique external preparation and preparation method. Background technique [0002] The unique Lamiophlomis rotata (Benth.) Kudo is a labiatae plant, and its roots and rhizomes are used as medicine. The main function is to promote blood circulation and remove blood stasis, reduce swelling and relieve pain. It is used for bruises, fractures, waist sprains, rheumatic arthralgia, muscle and bone pain, etc. The drug with unique ingredients as the main active ingredient has analgesic, anti-inflammatory, and blood-activating properties. Its efficacy is widely used in the treatment of traumatic trauma such as fractures, bruises, sprains, etc. and rheumatic diseases such as rheumatic arthralgia, muscle and bone pain and rheumatic diseases. [0003] In recent years, the research on the unique drug is very active, and a large number of unique drugs are used as oral preparations...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K36/534A61K36/54A61K47/10A61K47/14A61K47/08A61K9/70A61P19/00A61P29/00A61P19/08A61K31/045A61K31/125A61K31/618A61K125/00
Inventor 唐良平
Owner 唐良平
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