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Composition of reduced glutathione and sodium carbonate or sodium bicarbonate

A kind of technology of glutathione and sodium bicarbonate

Active Publication Date: 2012-10-10
GUANGZHOU BAIYUSN TIANXIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the dosage form of reduced glutathione for injection is mainly freeze-dried powder injection, which is reduced glutathione sodium, but the freeze-drying technology has great inconvenience in production, such as large-scale equipment, investment and operation High cost, low drying efficiency, long drying time, high capacity consumption, high cost, etc.
[0005] In addition, the stability of reduced glutathione sodium is much worse than that of reduced glutathione, mainly in two aspects: one is that reduced glutathione sodium is easily oxidized and converted into oxidized glutathione , this easy oxidation is more prominent after the product is dissolved, resulting in a reduction in the content of the product, a reduction in curative effect, and immeasurable harm to patients; second, reduced glutathione sodium is very easy to absorb moisture, which is harmful to production and storage. and transportation conditions are more stringent

Method used

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  • Composition of reduced glutathione and sodium carbonate or sodium bicarbonate
  • Composition of reduced glutathione and sodium carbonate or sodium bicarbonate
  • Composition of reduced glutathione and sodium carbonate or sodium bicarbonate

Examples

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Embodiment 1

[0033] Weigh 100g of reduced glutathione and mix it with 50.00g of sodium carbonate. After mixing the powder for 1 hour, pack it according to the specification of 0.3g and squeeze the cap to get it.

Embodiment 2

[0035] Weigh 150g of reduced glutathione and mix it with 12.45g of sodium carbonate. After mixing the powder for 1 hour, pack according to the specification of 0.6g and squeeze the cap to get it.

Embodiment 3

[0037] Weigh 120g of reduced glutathione and mix it with 22.50g of sodium carbonate. After mixing the powder for 1 hour, pack according to the specification of 0.9g and squeeze the cap to get it.

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Abstract

The invention relates to a composition of reduced glutathione and sodium carbonate or sodium bicarbonate, which is used for medical injection drugs. The invention also discloses that in the composition of the reduced glutathione and the sodium carbonate or the sodium bicarbonate, the weight ratio of the reduced glutathione and the sodium carbonate is 1: 0.083-0.500, and the weight ratio of the reduced glutathione and the sodium bicarbonate is 1: 0.132-0.792. The composition has the advantages of good stability, high production efficiency, low cost and low energy consumption.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a composition of reduced glutathione (glutathione), namely N (N-L-r-glutamyl-L-cysteinyl) glycine and sodium carbonate or sodium bicarbonate. technical background [0002] Reduced glutathione is a peptide naturally synthesized in human cytoplasm. It is composed of glutamic acid, cysteine ​​and glycine, and contains sulfhydryl (-SH). has played an important role. It is the prosthetic group of glyceraldehyde phosphate dehydrogenase, and the coenzyme of glyoxalase and triose dehydrogenase, and participates in the tricarboxylic acid cycle and glucose metabolism in the body. This product can activate a variety of enzymes, thereby promoting the metabolism of sugar, fat and protein, and can affect the metabolic process of cells; it can be converted into easily metabolized acid substances through the combination of thiol and free radicals in the body to accelerate the metabolism of free ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/06A61K47/02A61P1/16A61P39/02A61P39/06
Inventor 谭胜连司徒小燕陈大为
Owner GUANGZHOU BAIYUSN TIANXIN PHARMA