Application of cupric glutamate or derivatives thereof as feed additive for promoting animal growth

Abstract

The invention discloses application of cupric glutamate or derivatives thereof as feed additive for promoting animal growth; the cupric glutamate which has the advantages of low water solubility, strong acid resistance and high bioavailability is firstly found, the cupric glutamate is used as the feed additive for promoting animal growth and has high safety and antibiosis activity compared with other copper sources, such as copper sulfate, copper oxychloride, glycine copper and the like, the additive amount of the copper ions can reduce 60-80 percent, the production cost is reduced and the environment pollution is reduced, and the toxic and side effect of high copper to the animals is reduced simultaneously.

Description

technical field [0001] The invention particularly relates to the application of copper glutamate or a derivative thereof as an animal growth-promoting feed additive, belonging to the field of feed. Background technique [0002] Copper is one of the essential trace elements for animals, and it participates in animal hematopoiesis, metabolism, growth and reproduction, and disease resistance. Animals have a nutritional requirement of copper at 5-8mg / kg, but since it was discovered in 1945 that high copper can significantly improve the growth performance of pigs, 200-250ppm (quality) high copper (in the form of Copper ion meter), high copper has the effect of coagulating protein, reducing the proliferation of microorganisms, stimulating the secretion of neuropeptide Y (NPY), thereby promoting animal feed intake, improving the activity of digestive enzymes, and ultimately improving growth performance. Therefore, the use of high copper in pigs has become the "habit" of many nutri...

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Problems solved by technology

However, the use of high copper brings many side effects, mainly as follows: (1) the damage of high copper to the organs of the body, the use of 200ppm high copper can cause hepatocyte enlargement, cytoplasmic particle degeneration, glomerulus enlargement, renal tubule Swelling, exudation of protein in the renal capsule, degeneration of myocardial fiber granules, reduction of subsplenic lymphocytes, and hyperplasia of smooth muscle fibers. It has been proved by experiments that the proportion of dermatitis nephrotic syndrome in high-copper weaned piglets is more than 5% higher than that of low-copper pigs, indicating that high-copper It is one of the causes of porcine dermatitis nephrotic syndrome and one of the reasons for the decline of pig resistance; (2) high copper residues in organs exceed the standard, affecting food safety

The hygienic standard for copper limit in meat food in my country (GB15199-94) does not exceed 10mg / kg, but if 250ppm high copper is added to the basic diet of piglets, the copper content in the liver is 186.27mg / kg; (4) high copper can interfere with other Absorption of nutrients, such as high copper can oxidize vitamins and oils in feed, resulting in vitamin deficiency in pigs, rough fur and reduced feed quality; high copper antagonizes the absorption of iron and zinc, resulting in iron deficiency anemia, rough skin, hair loss, etc. Zinc deficiency Symptoms; (4) high copper also has huge environmental pressure. In terms of a ten thousand pig farm, the compound of copper is discharged up to 2.5 tons every year. low yield

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