Use of catechin for preparing retrovirus integrase inhibitors
An integrase inhibitor, retrovirus technology, applied in the direction of antiviral agents, drug combinations, medical preparations containing active ingredients, etc. Small side effects, good therapeutic effect and low cost
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Example Embodiment
[0031] Specific embodiment one, taking HIV as an example, the mechanism of action of the present invention is described in detail:
[0032] Integrase is a key enzyme in the HIV life cycle, no less important than protease and reverse transcriptase. It is a key enzyme for HIV integration into the human genome. Therefore, designing HIV-inhibiting drugs against integrase can prevent HIV from entering the human genome, thereby completely curing AIDS. At the same time, there is no protein structure homologous to HIV integrase in the human body, so the toxic and side effects of the enzyme-related drugs are reduced.
[0033] Each HIV virion carries 40-100 integrases. The main function of integrase is to integrate viral cDNA into the host genome. After reverse transcription, HIV forms double-stranded cDNA, and in the host cell cytoplasm, HIV begins to mediate 3'-processing under the action of integrase. The integrase first recognizes the two terminal regions of the viral cDNA, and ...
Example Embodiment
[0041] Specific embodiment two, taking human T lymphotropic virus as an example:
[0042] Human T-cell Lymphotropic Virus (HTLV) belongs to retrovirus in virus classification. Human T-lymophilic viruses are divided into HTLV-I and HTLV-II. Studies have shown that HTLV-I is the etiological factor of adult T-lymphocytic leukemia (ATL), and tumor cells in the patient's blood or tissue are marked by CD. + 4 Mainly, often accompanied by liver, spleen, lymph node enlargement, serum calcium, bilirubin, lactate dehydrogenase and white blood cells increased, the disease of adult T lymphocytic leukemia is progressive, the prognosis is very poor.
[0043] HTLV-I can also lead to tropical spastic paralysis, HTLV-I-associated myelopathy (TSP / HAM) and other diseases. TSP / HAM is a chronic, progressive neurological disorder characterized by spinal cord degeneration and CD in peripheral blood and cerebrospinal fluid + 4 Infiltration of cytotoxic T lymphocytes.
[0044] Retroviral integra...
Example Embodiment
Specific embodiment three:
[0046] The catechin compounds with galloyl groups have been screened through a large number of experiments to inhibit HIV-1 integrase, which can prevent HIV from entering the human genome and hinder its stable expression, bringing hope for a complete cure for AIDS.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap