Surface modification method of bio-absorbable material implanted in polyester

Abstract

The invention discloses a surface modification method of a bio-absorbable material implanted in a polyester, and the bio-absorbable material implanted in the polyester is treated by supercritical fluid. The invention utilizes the supercritical carbon dioxide technology to modify the surface of various existing internally absorbable implanted materials, so as to form holes with nanometer size or micron size on the surface of the material, the invention solves the problem that the interface of existing internally absorbable implanted material is not suitable for cell adhesion and proliferation, thereby facilitating protein adsorption and deposition of extracellular matrix, and integration with the surrounding tissues; moreover, the invention can form tiny blood vessels timely, and can achieve good synchronization of material degradation and replacement of bone cells.

Description

technical field [0001] The invention relates to a surface modification method, in particular to a surface modification method for bioabsorbable polyester internal implant materials. Background technique [0002] Bioabsorbable materials for implantation in the body are materials that can automatically break molecular chains under physiological conditions, change from large molecules to small molecules, from insoluble substances to soluble substances, and finally be gradually metabolized or absorbed by the body. At present, the more commonly used in vivo absorbable materials include polyester in vivo absorbable polymer materials, such as polylactic acid, polyglycolide, polyglycolide-lactide copolymer, etc., and natural polymers, such as collagen, shell Polysaccharides, alginates, etc. [0003] Bioabsorbable implant materials in the body, which can be used to make various medical devices, such as in vivo degradable artificial teeth, skin, joints, kidneys, pancreas, heart, hear...

AI Technical Summary

Problems solved by technology

[0004] At present, various medical devices are made of bioabsorbable implant materials in vivo, which have disadvantages such as poor mechanical properties and slow degradation performance, mainly because the implant materials in vivo have a very dense and smooth surface, which is not conducive to cell adhesion and proliferation

Although it is also possible to improve cell adhesion and proliferation by doping osteoinductive inorganic particles such as hydroxyapatite into it, the current general practice is to spray hydroxyapatite particles on the outer surface of medical devices to achieve surface rough purpose

However, this does not improve cell adhesion very well, and it is difficult to realize the transportation and exchange of interstitial fluid and nutrients.

[0005] In addition, there is a method of punching holes on the surface of medical devices to improve cell adhesion and proliferation. However, due to limitations such as too low porosity, a small number of holes, and no direct connection with each other, cells are not easy to uniformly flow into the inside of medical devices. growth, it is difficult to achieve synchronization between the degradation of materials and the replacement of osteoblasts

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