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Method of collagen modification of medical metal implant surface

A technology of implants and collagen, applied in the direction of coating, etc., can solve the problems of slow bone tissue integration, limited biological activity, long healing time, etc., and achieve the effect of easy industrialization, simple process, and improved strength

Inactive Publication Date: 2010-08-04
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the biological activity of the pure hydroxyapatite coating is limited, which makes the implants in the body slowly combine with the bone tissue, the healing time is long, and the effect is not good.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0013] Dissolve collagen in an acetic acid solution with a pH value of 3.5 to obtain a 0.3 g / L collagen solution, and then press Ca in the collagen solution 2+ Ion concentration 0.2g / L, PO 4 3- Add CaCl at a concentration of 0.1g / L 2 and H 3 PO 4 , forming solution A;

[0014] Hexamethylenetetramine is made into a solution with a pH value of 7.5 (solution B), and a liquid film is formed on the surface of a titanium metal medical implant with a hydroxyapatite coating by dipping and pulling, and is heated at 80° C. Then put it into the solution A, soak it for 36 hours, then place it in an oven at 40° C. and dry it for 18 hours to obtain the collagen-modified implant.

example 2

[0016] Dissolve the collagen in a dilute hydrochloric acid solution with a pH value of 1.0 to obtain a 4g / L collagen solution, and then press Ca in the collagen solution 2+ Ion concentration 1.0g / L, PO 4 3- Add CaCl at a concentration of 1.0g / L 2 and H 3 PO 4 , forming solution A;

[0017] Trishydroxymethylaminomethane was made into a solution (solution B) with a pH value of 8.2, and a liquid film was formed on the surface of a titanium alloy medical implant with a fluorine-containing hydroxyapatite coating by dipping and pulling, and the liquid film was formed at 75 and then dried at 8°C for 8 hours; then put into solution A, soaked for 48 hours, and then dried in an oven at 40°C for 15 hours to obtain the collagen-modified implant.

example 3

[0019] Dissolve collagen in an acetic acid solution with a pH value of 2.0 to obtain a 0.3 g / L collagen solution, and then press Ca in the collagen solution 2+ Ion concentration 3.0g / L, PO 4 3- Add CaCl at a concentration of 1.4g / L 2 and H 3 PO 4 , forming solution A;

[0020] Diethylenetriamine was made into a solution (solution B) with a pH value of 7.5, and a liquid film was formed on the surface of a cobalt-chromium-molybdenum alloy medical implant with a tricalcium phosphate coating by dipping and pulling, and baked at 20°C Dry for 48 hours; then put it into solution A, soak for 24 hours, and then place it in an oven at 30° C. for 20 hours to obtain the collagen-modified implant.

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PUM

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Abstract

The invention discloses a method of collagen modification of medical metal implant surfaces. A medical metal implant with a bioactive coating is taken as a matrix, and the surface of the medical metal implant is pre-coated with an organic alkali or inorganic alkali inducing layer, so that collagen molecules are assembled into collagen fibers under the alkaline environment, and further the collagen fibers are adhered to the outer side of the bioactive coating of the medical metal implant to form a collagen fiber layer. Since collagen is a major component of extracellular matrix, and the outer layer of the collagen can effectively improve the biocompatibility and bioactivity of the medical metal surface. The collagen modified medical metal implant obtained from the invention can overcomes the defects that the commercially medical metal implant surface has low activity, slow tissue repair, long time required for curing and the like, and effectively improves the adhesion strength of the collagen layer to the metal implant surface. The invention has simple preparation process, high efficiency and easy industrialization.

Description

technical field [0001] The invention relates to a method for modifying surface collagen of a medical metal implant used for hard tissue repair or replacement. Background technique [0002] Medical metal materials, such as titanium and its alloys, cobalt-chromium-molybdenum alloys and medical stainless steel, have been widely used in clinical treatment of orthopedics, dentistry and other tissue trauma or diseases due to their good biocompatibility and excellent mechanical properties. For example, the Chinese patent CN1064610 adopts the plasma spraying process to directly spray the hydroxyapatite coating on the dental metal surface, and the Chinese patent CN1316274 adopts the electrolytic deposition method to prepare the hydroxyapatite coating, etc. However, the pure hydroxyapatite coating has limited biological activity, which makes the implant slowly combine with the bone tissue in vivo, and the healing time is long and the effect is not good. The use of inorganic or organi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/28
Inventor 程逵任常宝洪国林刘海镇龙国云王秋英翁文剑
Owner ZHEJIANG UNIV