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Nimesulide suspension and preparation method thereof

A technology of suspension and suspending agent, applied in the field of medicine, can solve problems such as poor taste of capsules, inability to take, difficult to accurately control drug dosage, etc., and achieve the effects of fast onset, good drug efficacy, and improved compliance.

Inactive Publication Date: 2010-08-25
祝瑞章
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the dosage forms of this product mainly include tablets, granules, and capsules, all of which are packed in quantitative quantities. It is difficult to accurately control the dosage of the drug when children take it. However, the nimesulide suspension is equipped with a small plastic beaker with a marked volume. Accurately measure the child's weight to take the required dose
The taste of tablets and capsules is poor, and some children are reluctant to take it actively. Granules are better than tablets and capsules in terms of taste, but they cannot be taken without water

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1. Prescription (in 1000ml product, the content of each raw material):

[0038] Nimesulide 30g

[0039] Sodium Carboxymethyl Cellulose 2g

[0040] Hydroxypropyl Cellulose 3g

[0041] Hydroxypropyl Methyl Cellulose 3g

[0042] Glycerin 198g

[0043] Sorbic acid 1.5g

[0044] Sucrose 250g

[0045] Stevioside 1g

[0046] Fragrance 15ml

[0047] Disodium edetate 0.5g

[0048] Tween-80 30g

[0049] Carmine 20mg

[0050] Tartrazine 20mg

[0051] 2. Process steps:

[0052] 1) Making Simple Syrup

[0053]Add appropriate amount of purified water to sucrose, heat to boiling, heat preservative, keep warm for 20 minutes, and filter.

[0054] 2) Nimesulide microparticles

[0055] Nimesulide and Tween-80 are evenly mixed and ground into particles with a particle size not greater than 10 microns.

[0056] 3) Swelling of the suspending agent

[0057] Sodium carboxymethyl cellulose, hydroxypropyl cellulose, and hydroxypropyl methyl cellulose were added with appropriate a...

Embodiment 2

[0061] Prescription (in 1000ml product, the content of each raw material):

[0062] Nimesulide 10g

[0063] Sodium Carboxymethyl Cellulose 5g

[0064] Tragacanth Gum 3g

[0065] Glycerin 50g

[0066] Sodium Benzoate 1.5g

[0067] Sucrose 250g

[0068] Stevioside 1.5g

[0069] Fragrance 10ml

[0070] Disodium edetate 0.5g

[0071] Tween-80 30g

[0072] Carmine 20mg

[0073] Tartrazine 20mg

[0074] 2. The process steps are the same as those in Example 1.

Embodiment 3

[0076] Prescription (in 1000ml product, the content of each raw material):

[0077] Nimesulide 20g

[0078] Sodium Carboxymethyl Cellulose 10g

[0079] Carbomer 3g

[0080] Gum Arabic 3g

[0081] Glycerin 250g

[0082] Sorbic Acid or Potassium Sorbate 2g

[0083] Sucrose 250g

[0084] Stevioside 1g

[0085] Fragrance 15ml

[0086] Disodium edetate 1g

[0087] Tween-80 30g

[0088] Carmine 20mg

[0089] Tartrazine 20mg

[0090] The process step of embodiment 2,3 is identical with embodiment 1.

[0091] In order to make the antiseptic exert the best antibacterial effect, during preparation, the pH of the nimesulide suspension is adjusted to 3.0-5.0 by using conventional acid or alkali during drug preparation.

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Abstract

The invention discloses a nimesulide suspension and a preparation method thereof, relating to the field of medicine, in particular to the technical field of pharmacy by taking nimesulide as a raw material. Firstly, cane sugar, a preservative and purified water are mixed and heated to be prepared into simple syrup; the nimesulide is evenly mixed with Tween-80 to be prepared into particles with the particle diameter less than or equal to 10 micrometers; after the purified water is added into a suspending agent for swelling, the mixture is mixed with glycerol; and after the above three materials are mixed, and pigment, Stevioside and essence are added to be evenly stirred. The invention has simple process, easy production and operation, is favorable for quick adsorption after being taken and can quickly reach the treatment purpose, and the medicine has favorable curative effect and is convenient to carry and store.

Description

technical field [0001] The invention relates to medicine, in particular to the technical field of pharmacy using nimesulide as a raw material. Background technique [0002] Nimesulide is a non-steroidal antipyretic, analgesic, anti-inflammatory drug, mainly used for chronic arthritis (such as rheumatoid arthritis and osteoarthritis, etc.), pain and inflammation after surgery and acute trauma, ear nasopharynx Treatment of pain caused by inflammation, dysmenorrhea, fever caused by upper respiratory tract and other symptoms. [0003] Non-steroidal antipyretic, analgesic, and anti-inflammatory drugs all work by inhibiting the activity of cyclooxygenase (COX), reducing the synthesis and release of prostaglandins, and restoring the normal response of central sensory neurons. COX has two isomerases, COX-1 and COX-2. COX-1 is a normal tissue component, distributed in normal tissues such as stomach (intestine) wall, kidney and platelets, while COX-2 appears in inflammatory tissues ...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/18A61P29/00A61P19/02A61P15/00
Inventor 祝瑞章
Owner 祝瑞章
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