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Xylitol particles capable of being directly pressed into tablets and preparation method thereof

A xylitol and tabletting technology, applied in the field of functional sugar, can solve the problems of low xylitol purity, long production cycle, and small production scale, and achieve the effects of high xylitol purity, simple production process, and convenient operation

Inactive Publication Date: 2010-10-27
FUTASTE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The object of the present invention is to provide a kind of xylitol granules that can be directly compressed into tablets and its preparation method, to solve the problems of small production scale, complicated operation, long production cycle, low yield, low purity of xylitol and the like in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] 1. Grinding and mixing: take 95.5 kg of xylitol, grind it into xylitol powder below 100 mesh, add 1.7 kg of sodium carboxymethyl cellulose powder with a viscosity of 1500 mPa. Heat for 10 minutes.

[0022] 2. Prepare binder solution: Take another 1.5kg of xylitol and 0.3kg of sodium carboxymethyl cellulose with a viscosity of 1500mPa.S, dissolve it with 30kg of hot water at 60°C under high-speed stirring, and filter it into the spray liquid storage while it is hot. Reserve in can.

[0023] 3. Granulation: At 65°C, spray liquid for 1.3 hours and granulate with a boiling granulator. Continue to dry for 10 minutes after spraying, and then pour in cold air to cool down to room temperature, so that the prepared particles are not easy to deliquescence. Measure water content and other indicators, and screen out larger particles and fine powder after passing the test to obtain xylitol granules that can be directly compressed into tablets.

[0024] 4. Tabletting: Add 1% magne...

example 2

[0026] 1. Mixing: Take 98kg of xylitol, grind it into xylitol powder below 100 mesh, add 1.6kg of methyl cellulose powder with a viscosity of 1900mPa.S, add it to the boiling granulator and mix, preheat for 5-10min .

[0027] 2. Prepare adhesive solution: Take another 2kg of xylitol and 0.4kg of methyl cellulose with a viscosity of 1900mPa.S, dissolve it with 40kg of hot water at 60°C under high-speed stirring, and filter it into the spray liquid storage tank while it is hot. .

[0028] 3. Granulation: At 60°C, spray liquid for 1.5 hours and granulate with a boiling granulator. Continue to dry for 5 to 10 minutes after spraying, and then pour in cold air to cool down to room temperature, so that the prepared particles are not easy to deliquescence. Measure water content and other indicators, and screen out larger particles and fine powder after passing the test to obtain xylitol granules that can be directly compressed into tablets.

[0029] 4. Tabletting: Add 1% magnesium ...

example 3

[0031] 1. Mixing: Take 94kg of xylitol, grind it into xylitol powder below 100 mesh, add 1.8kg of hydroxypropyl methylcellulose powder with a viscosity of 900mPa.S, add it to a boiling granulator, mix and preheat 5min.

[0032] 2. Prepare binder solution: Take another 1kg of xylitol and 0.2kg of hydroxypropyl methylcellulose with a viscosity of 900mPa.S, dissolve it with 20kg of hot water at 60°C under high-speed stirring, and filter it into the spray liquid storage while it is hot. Reserve in can.

[0033] 3. Granulation: At 65°C, spray liquid for 1 hour and granulate with a boiling granulator. Continue to dry for 5 minutes after spraying, and then inject cold air to cool down to room temperature, so that the prepared particles are not easy to deliquescence. Measure water content and other indicators, and screen out larger particles and fine powder after passing the test to obtain xylitol granules that can be directly compressed into tablets.

[0034] 4. Tabletting: Add 1%...

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Abstract

The invention relates to xylitol particles capable of being directly pressed into tablets and a preparation method thereof, belonging to the technical field of functional sugar, and the xylitol particles comprise the following raw materials by weight ratio: 95-120kg of crystal xylitol and 0.1-5kg of adhesive, wherein the adhesive adopts one of polydextrose or sodium carboxymethyl cellulose in cellulose ether or hydroxypropyl methyl cellulose in methyl cellulose, the viscosity number of the adhesive is 500-2000mPa.S, the using amount of the sodium carboxymethyl cellulose and the methyl cellulose is 0.1-5kg, the using amount of the polydextrose is 3-5kg, and the using amount of water is 20-50kg. The preparation method comprises the following steps: 1) mixing; 2) preparing solution; 3) granulating; and 4) pressing into the tablets, adding the obtained particles into 1% of magnesium stearate, uniformly mixing, pressing into the tablets by using a tablet press machine, and obtaining high-purity xylitol tablets. The prepared high-purity xylitol tablets have the advantages of good stability, high dissolution rate, low friability, high hardness and the like.

Description

technical field [0001] The invention belongs to the technical field of functional sugars, and relates to a xylitol granule for direct tableting and a manufacturing method thereof. technical background [0002] Xylitol is a natural dietary health sugar alcohol and a normal sugar metabolism intermediate for humans. Its chemical formula is C 5 h 12 o 5 , white crystal or crystalline powder, easily soluble in water. Xylitol is used in food and pharmaceutical raw materials due to its functional properties such as sugar-free, moisturizing, sweet taste, and health care. After eating, it has no cariogenicity, does not cause blood sugar to rise, improves liver function, improves gastrointestinal function, and promotes the absorption of trace elements such as calcium. It also has a pleasant refreshing feeling and a sweetness comparable to sucrose, and is favored by people. It is widely used in the processing of various low-sugar (sugar-free), caries-preventing, and low-calorie (...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L1/09A23L29/30A23L33/125
Inventor 李毅姜希生张亮周娟
Owner FUTASTE PHARM CO LTD
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