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Application of 5-aminolevulinic acid in preparing medicaments for treating HPV (Human Papilloma Virus) infection

A technology of aminolevulinic acid and HPV virus, applied in antiviral agents, drug combinations, diseases, etc., can solve the problems of long treatment cycle, unsatisfactory curative effect, vaginal mucosa damage, etc., and achieve the effect of fast drug metabolism

Inactive Publication Date: 2010-11-03
上海复旦张江生物医药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 5-Fu is a cytotoxic drug that limits the DNA and RNA synthesis of HPV. Local injection has a significant effect, but it may cause chemical vaginitis. Long-term use can also cause damage to the vaginal mucosa and even vaginal stenosis
In recent years, physicians have used more immune drugs to treat HPV infection, the most commonly used is interferon, and others include interleukin-12, etc. This kind of treatment requires injection, and the treatment cycle is usually longer. HPV virus has no obvious specificity, and any treatment cannot solve the situation of HPV recurrence, and the final curative effect cannot satisfy patients

Method used

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  • Application of 5-aminolevulinic acid in preparing medicaments for treating HPV (Human Papilloma Virus) infection
  • Application of 5-aminolevulinic acid in preparing medicaments for treating HPV (Human Papilloma Virus) infection
  • Application of 5-aminolevulinic acid in preparing medicaments for treating HPV (Human Papilloma Virus) infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Hydrochloride-5-Aminolevulinic Acid Treatment of Persistent Infection, Infection with Viral Load ≥ 10

[0026] Patient selection method: The patients were detected by the HC2 second-generation hybridization capture technology, and the second detection was performed at least one year later. During the two detection periods, the patients did not receive photodynamic therapy with 5-aminolevulinic acid hydrochloride. Those who were positive twice were selected.

[0027] Medication method: use 500mg / hypohydrochloride-5-aminolevulinic acid powder, pour the powder into the temperature-sensitive gel (2ml), stir gently to make it evenly mixed, or dissolve it in sterile aqueous solution to prepare a solution with a concentration of 23%. agent. Clinical treatment of 86 patients with high-risk HPV infection, all patients had HPV infection for more than 1 year, and the viral load was greater than 10.

[0028] Apply the gel or solution evenly on the patient's vagina and c...

Embodiment 2

[0030] Example 2 Interferon treatment of persistent infection, the method of HPV infection with viral load ≥ 10

[0031] Another 30 patients with high-risk HPV infection were treated with interferon as a control. All patients were selected in the same way as above, and all of them had HPV infection for more than 1 year, and their viral load was ≥10. The treatment plan is: recombinant interferon α-2a suppository, 6×10 4 IU / capsule, non-menstrual vaginal administration, place the suppository in the posterior fornix of the vagina, 1 capsule / time, once every other day. 6 times as a course of treatment, 2 consecutive courses of treatment. Follow-up and HPV detection were performed 1 month and 3 months after the end of treatment.

Embodiment 3

[0032] Example 3 Follow-up results of hydrochloride-5-aminolevulinic acid and interferon in the treatment of persistently infected HPV

[0033] 1), 5-aminolevulinic acid group: a total of 86 patients, 7 cases dropped out, and 79 cases remained. During the first follow-up visit, 46 patients had their HPV virus detection changed from positive to negative (viral titer was lower than 1), accounting for 58.2%, and 71 patients had their HPV virus detection value dropped below 10, accounting for 89.87%; the remaining 8 The detection value of HPV in 1 patient decreased, but the decrease was not obvious. During the second follow-up visit, 67 patients had negative virus tests, accounting for 84.8%, and 77 patients had virus titers lower than 10, accounting for 97.5%. The number of patients who relapsed after one year of follow-up observation and turned negative was zero.

[0034] Comparison of the effect of 5-aminolevulinic acid hydrochloride on the titer of different viruses after on...

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Abstract

The invention relates to application of 5-aminolevulinic acid or pharmaceutically acceptable salts thereof or a medicament composition containing the 5-aminolevulinic acid or the pharmaceutically acceptable salts thereof in preparing medicaments for treating HPV (Human Papilloma Virus) infection, which is characterized by being applied to treating patients with continuous high-risk HPV infection with viral load not less than 10. When in treatment implementation, the invention is very safe and has no haemorrhage or anesthesia in the treatment process, pathological tissues can be selectively damaged, normal cervical tissue structures a re reserved, and the invention has no influence on the reproductive function of the patient, can be used for repetitive treatment, and has fast drug metabolism, no phototoxicity and no need of being kept in the dark.

Description

technical field [0001] The present invention relates to the application of 5-aminolevulinic acid, especially the application of 5-aminolevulinic acid and its pharmaceutically acceptable salt in the preparation of medicine for treating HPV virus infection. Background technique [0002] Human papillomavirus (HPV) is a group of non-enveloped small DNA viruses belonging to the Papillomaviridae family. It can infect human skin and mucosal epithelial tissues, induce verrucous hyperplasia and even cause benign and malignant tumors. [0003] So far, 118 HPV virus subtypes have been isolated and identified. According to the different infection sites, HPV can be divided into two categories: skin-tropic group and mucous-tropic group. According to the benign and malignant lesions induced by infection, the mucotropic group is divided into: a. High-risk HPV that induces malignant hyperplasia of epithelial tissue, including 15 types of HPV-16, -18, -45, -52, etc., high-risk HPV HPV infect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/197A61P31/20A61P15/00A61P17/00
Inventor 曹峰宗良飞任晓岚苏勇
Owner 上海复旦张江生物医药股份有限公司
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