Segmented copolymer modified by polyethylene glycol 1000 vitamin E succinic acid ester, preparation method and applications thereof

A technology of polyethylene glycol and succinate, which is applied in the field of biomedical materials, can solve the problems of difficult operation of pharmaceutical preparations, low mechanical strength, and difficulty in bending, and achieve a wide range of biomedical applications. The method is simple and fast, and biodegradation is improved. speed effect

Active Publication Date: 2010-11-10
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its melting point is high, its flexibility is poor, it is not easy to bend, and its mechanical strength is not high, so it is difficult to make complex shapes such as screws, etc.
As a drug carrier, PGA degrades quickly, especially in a short period of time, and its strength decays quickly. Under normal conditions, the strength of PGA drops by more than 50% after 14 days in the tissue. However, as a drug carrier, it is insoluble in many conventional solvents. This makes the handling of pharmaceutical preparations relatively difficult

Method used

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  • Segmented copolymer modified by polyethylene glycol 1000 vitamin E succinic acid ester, preparation method and applications thereof
  • Segmented copolymer modified by polyethylene glycol 1000 vitamin E succinic acid ester, preparation method and applications thereof
  • Segmented copolymer modified by polyethylene glycol 1000 vitamin E succinic acid ester, preparation method and applications thereof

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Embodiment 1

[0029] CL, LA, GA, and TPGS were added to a 100-ml round-bottom flask with two necks in a mass ratio of 4:2:2:2 (10 g in total), and 5 ml of toluene was added. Add 50 mg of stannous octoate (the amount of stannous octoate is 0.5% of the total mass of CL, LA, GA and TPGS) into the flask with a micropipette. The resulting mixture was stirred and reacted at 145° C. for 16 hours under the protection of dry nitrogen. The obtained polymer was dissolved in dichloromethane, and cold methanol was added thereto and stirred to induce precipitation of the polymer. The precipitated polymer was dried at room temperature for 48 hours to obtain a caprolactone-lactic acid-glycolic acid block copolymer modified with polyethylene glycol 1000 vitamin E succinate.

[0030] Take the polyethylene glycol 1000 vitamin E succinate-modified caprolactone-lactic acid-glycolic acid block copolymer and mix it with potassium bromide and press it into tablets (the mass ratio of copolymer to potassium bromide...

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Abstract

The invention discloses a caprolactone-lactic acid-glycollic acid segmented copolymer modified by polyethylene glycol 1000 vitamin E succinic acid ester, a preparation method and applications thereof. The segmented copolymer is prepared by forming an ester bond by combing hydroxyl in polyethylene glycol 1000 vitamin E succinic acid ester and carboxyl in a construction unit A; and the construction unit A is a polymer by connecting polycaprolactone, polylactic acid and polyglycolic acid through the ester bond. The copolymer has excellent biodegradability, biocompatibility and nontoxicity, improves and regulates hydrophilcity and biodegradation rate of aliphatic polyester. The segmented copolymer is a new biodegradable polymer, and has wide biomedical applications.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a caprolactone-lactic acid-glycolic acid block copolymer modified with polyethylene glycol 1000 vitamin E succinate and an application thereof. Background technique [0002] The concept of using biodegradable polymers for the controlled release of active drugs and other therapeutic compounds has emerged and developed rapidly in the last 20 years. Polylactic acid (PLA), polyglycolic acid (PGA) and polycaprolactone (PCL) are three of the most important biodegradable biomaterials. Because they can be hydrolyzed, or degraded by enzymes and microorganisms, resulting in a decrease in molecular weight and loss of strength, so that they are eventually degraded into small molecules, monomers, or carbon dioxide and water. Using such materials as drug carriers can achieve long-term controlled release and constant rate release of drugs, as well as activity maintenance of biologic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/664A61K47/34A61K31/337A61P35/00A61K47/22
Inventor 严飞梅林黄来强郑义
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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