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Amoxicillin sustained-release preparation composition and preparation method thereof

An amoxicillin and sustained-release preparation technology, applied in the field of medicine, can solve problems such as poor patient compliance, and achieve the effects of delaying the release rate, improving compliance, and reducing the number of times of administration

Inactive Publication Date: 2010-11-24
北京瑞伊人科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In order to overcome the shortcomings of amoxicillin, such as taking medicine multiple times a day, resulting in poor patient compliance, the invention provides amoxicillin sustained-release preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Sustained Release Tablets

[0026] prescription:

[0027] Amoxicillin trihydrate 344.38g (calculated as amoxicillin 300.00g)

[0028] Hydroxypropyl methylcellulose 70.00g

[0029] Starch 70.00g

[0030] Microcrystalline Cellulose 60.00g

[0031] Magnesium Stearate 5.50g

[0032] 4% polyvinylpyrrolidone 75% ethanol solution appropriate amount

[0033]

[0034] Makes 1000 pieces

[0035] Preparation Process:

[0036] Pass amoxicillin trihydrate, hydroxypropyl methylcellulose, starch, microcrystalline cellulose, and magnesium stearate through an 80-mesh sieve respectively for later use, and weigh hydroxypropyl methylcellulose, starch, After the microcrystalline cellulose is placed in a mixer and mixed evenly, it is then mixed with amoxicillin trihydrate in equal increments, and an appropriate amount of 4% polyvinylpyrrolidone 75% ethanol solution is added, granulated, granulated, and dried at 60°C. Add the prescribed am...

Embodiment 2

[0038] Sustained Release Tablets

[0039] Prescription: plain tablet

[0040] Amoxicillin 450.00g

[0041] Starch 23.00g

[0042] Lactose 22.00g

[0043] Magnesium Stearate 5.00g

[0044] 4% polyvinylpyrrolidone 75% ethanol solution appropriate amount

[0045]

[0046] Makes 1000 pieces

[0047] Prescription: Sustained-release coating solution

[0048] 25 parts of hydroxypropyl methylcellulose

[0049] 10 parts ethyl cellulose

[0050] Propylene glycol 5 parts

[0051] Titanium dioxide 6 parts

[0052] talcum powder 4 parts

[0053] 2% ethyl cellulose ethanol solution appropriate amount

[0054] Preparation Process:

[0055] Pass amoxicillin, starch, lactose, and magnesium stearate through a 100-mesh sieve respectively, weigh amoxicillin, starch, and lactose according to the prescription amount, mix them in a mixer, and add an appropriate amount of 4% polyvinylpyrrolidone 75% ethanol solution , granulated, dried at 65°...

Embodiment 3

[0057] Sustained Release Capsules

[0058] prescription:

[0059] Amoxicillin 300.00g

[0060] Hydroxypropyl methylcellulose 60.00g

[0061] Ethyl cellulose 20.00g

[0062] Lactose 32.00g

[0063] Magnesium Stearate 4.00g

[0064] 4% polyvinylpyrrolidone 85% ethanol solution appropriate amount

[0065]

[0066] Makes 1000 capsules

[0067] Preparation Process:

[0068] Pass amoxicillin, hydroxypropyl methylcellulose, ethyl cellulose, lactose, and magnesium stearate through an 80-mesh sieve respectively, and weigh hydroxypropyl methylcellulose, ethyl cellulose, lactose, Magnesium stearate is placed in a mixer and mixed evenly, then mixed evenly with amoxicillin according to the method of equal increase, 4% polyvinylpyrrolidone 85% ethanol solution is used to make a soft material in an appropriate amount, and granulated in a granulator. The granules prepared above were dried at 60°C. Then pass through a swinging granulator...

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PUM

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Abstract

The invention discloses an amoxicillin sustained-release preparation composition and a preparation method thereof, and the amoxicillin sustained-release preparation composition is mainly prepared by amoxicillin bulk drug, sustained-release material and other proper auxiliary materials. The provided amoxicillin sustained-release preparation can slow down the release rate of main drug, reduces the medicine taking times and improves the compliance of patients. The invention provides the amoxicillin sustained-release preparation composition, and the preparation technique of the composition has good quality controllability and stability.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to an amoxicillin sustained-release preparation composition and a preparation method thereof. Background technique [0002] Amoxicillin, its chemical name is: (2S,5R,6R)-3,3-Dimethyl-6-[(R)-(-)-2-amino-2-(4-hydroxyphenyl)acetyl Amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate, a broad-spectrum penicillin β-lactam semisynthetic antibiotic, the mechanism of action is Inhibits the synthesis of bacterial cell walls, has a rapid bactericidal effect, and is effective against most Gram-positive and negative bacteria. It has a good effect on enzyme-producing Staphylococcus aureus, Staphylococcus epidermidis, coagulase-negative staphylococcus and enterococcus, and has a good effect on certain β-lactamase-producing Enterobacteriaceae bacteria, Haemophilus influenzae, and Mora catarrhalis bacteria, Bacteroides fragilis, etc. also have good antibacterial activity. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/43A61K9/16A61K9/22A61K9/52A61K47/26A61K47/32A61K47/34A61K47/36A61K47/38A61K47/42A61P31/04
Inventor 安英张慧英张玲玲
Owner 北京瑞伊人科技发展有限公司
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