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Medicinal hollow capsules and preparation method and manufacturing equipment thereof

A technology for hollow capsules and manufacturing equipment, which is applied in capsule transportation, pharmaceutical formulations, drug delivery, etc. It can solve problems such as impact on human safety, large discharge of process wastewater, and high pressure on environmental protection, so as to reduce process water consumption, Obvious advantages, thorough sterilization effect

Active Publication Date: 2011-01-26
ZHEJIANG ANGLIKANG CAPSULE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] One is that the capsules contain parabens (paraben, such as ethyl paraben, etc.) preservatives, which will affect the safety of the human body after use, and the waste water will have a greater impact on the environment after discharge
[0004] Second, the discharge of process wastewater is large
If it is a colored capsule, food coloring should be added in the production, and the waste water produced will be even more colorful, which will put more pressure on environmental protection.
[0005] The third is to use ethylene oxide to sterilize to cause environmental pollution and affect human health.
At the same time, the ethylene glycol esters, ethylene glycol ethers, and chloroethanols produced by the action of ethylene oxide and amino acids in gelatin have greater toxic and side effects on the human body.

Method used

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  • Medicinal hollow capsules and preparation method and manufacturing equipment thereof
  • Medicinal hollow capsules and preparation method and manufacturing equipment thereof
  • Medicinal hollow capsules and preparation method and manufacturing equipment thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Small batch production can be carried out directly in the ultrasonic sol tank. After the production system is cleaned, inject 34.5L of purified water into the ultrasonic sol tank, add 15Kg of gelatin, turn on the ultrasonic power supply, first select the low power button, wait for the temperature to rise to 45°C, select the medium or high power button, and vacuum slowly, 30 Minutes to 50 minutes later, after sampling and testing the clarity to pass, the sol process is completed.

Embodiment 2

[0030] Mass production can adopt ultrasonic and variable speed stirring combined sol method. After the production system is cleaned, pour 92L of purified water into the stirring sol tank, add 40Kg of gelatin, and start stirring. The stirring speed can be selected from 30 to 60 rpm. When the temperature rises to 45°C, start the sanitary pump or peristaltic pump, slowly inject the material liquid into the high-level ultrasonic sol tank, turn on the ultrasonic power supply, select the medium or high power button, and slowly pump air under vacuum. After 30 minutes to 50 minutes, after After sampling and testing the clarity is qualified, the sol process is completed.

Embodiment 3

[0032] After the sol is completed, add 120g of sodium lauryl sulfate to the glue, stir well, transfer to the color matching tank in which the cuttings have been dissolved, add food coloring, appropriate amount of titanium dioxide paste, filter, after the glue is defoamed and matured, enter the automation blank making, cutting, fitting and other processes to make hollow capsules.

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Abstract

The invention relates to the technical fields of medicinal auxiliary materials and preparation methods and equipment thereof in the biopharmaceutical industry, in particular to medicinal hollow capsules and preparation method and manufacturing equipment thereof. The medicinal hollow capsules consist of gelatin, water, a surfactant, a coloring agent and / or an opacifier. The preparation method comprises the following steps of gelatin dissolution; color blending; and sterilization, wherein in the step of gelatin dissolution, ultrasonic gelatin dissolution or a mode of combining ultrasound and stirring is adopted; and the ozone sterilization is adopted in the step of sterilization. The manufacturing equipment comprises gelatin dissolution equipment and sterilization equipment, wherein the gelatin dissolution equipment is fully made of stainless steel; and the ozone sterilization device is a semi-automatic or full-automatic sterilization device. The capsules do not contain any preservative and are safe to medicate; the production process is favorable for environmental protection due to less wastewater discharge; and the ozone sterilization is thorough without residue.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical excipients, preparation methods and equipment in the biopharmaceutical industry. Specifically, it relates to a medicinal hollow capsule, a preparation method thereof and a manufacturing device thereof. Background technique [0002] Empty capsules are one of the most commonly used pharmaceutical excipients. Due to the improvement of people's living standards and medical standards, and the use of capsules in large quantities in nutritional and health products, the current annual consumption of empty capsules in China is estimated to be about 200 billion capsules. Although the raw materials used by different manufacturers are basically the same, and the production process has manual, semi-automatic and fully automatic production lines, there are three major defects. [0003] One is that the capsules contain parabens (paraben, such as ethyl paraben, etc.) preservatives, which will affect the s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/42A61J3/07
Inventor 徐成苗王智新俞乐军马海岭
Owner ZHEJIANG ANGLIKANG CAPSULE
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