Study and application of release technique of effective compound group of traditional Chinese Medical prescription

Abstract

The invention relates to study and application of a release technique of an effective compound group of a traditional Chinese medical prescription. The invention is characterized in that: the preparation consists of three parts, namely an osmotic pump tablet core, a semipermeable coating film and medicine release holes, wherein the tablet core simultaneously contains an osmotic pressure active substance and an osmosis promoting polymer (also named propellent), and comprises the following components in percentage by weight: 5 to 30 percent of traditional Chinese medicinal extract, 12 to 18 percent of osmotic pressure active substance, 20 to 40 percent of osmosis promoting polymer (also named propellent) and 5 to 10 percent of poloxamer; and the medicine release characteristic is that water-soluble components and insoluble components are synchronously released. The invention can overcome the defects of the conventional preparations, selects a membrane controlled-release technique, can constantly release the medicine, reduces administration frequency, and achieves near zero-order release, stable blood concentration and small side effect.

Description

1. Technical field [0001] The invention relates to the research and application of the release technology of the effective component group of the traditional Chinese medicine compound, which relates to the field of medical technology. 2. Background technology [0002] Traditional Chinese medicine has a long history, has a unique theoretical system of traditional Chinese medicine, and has definite curative effects. The idea of ​​taking slow and controlled release preparations has long been recorded in the medical classics of the motherland. Take effect or poison without hurting the spleen and stomach" vividly describe the slow and long-lasting characteristics of traditional Chinese medicine pills. But paste pills and wax pills of traditional Chinese medicine are only the prototypes of sustained and controlled release preparations. Although they have the concept of slow and controlled release in the thinking of the predecessors, they are not slow and controlled release prepar...

AI Technical Summary

Problems solved by technology

[0007] 2 At present, the research foundation of traditional Chinese medicine compound preparations (ordinary preparations) is weak, and the research on its absorption and utilization in vivo is basically blank. The in vivo absorption and action of a certain ingredient cannot represent the absorption, action characteristics and laws of the entire drug, so the in vivo pharmacokinetic parameters of a certain ingredient are not enough to be used as the basis for evaluating its clinical efficacy

Apply osmotic pump technology to Liuwei Dihuang Pills, Compound Danshen Tablets, Danggui Pills (Danggui, Astragalus), Shenfu Qiangxin Pills, Xinxuening Tablets (Puderaria Root Extract, Hawthorn Extract), Shenqi Tablets (Astragalus, Dangshen), Guyuan Tablets (Astragalus polysaccharide, Ginseng and Lutou), Shuanghuang Xiaoyan Tablets (Sankezhen, Scutellaria baicalensis), Danpi-Salvia, Chuanxiong-Danggui, Chuanxiong-Red Paeoniae, etc. Research on the synchronous release of different components (including insoluble components and water-soluble components), and there is no literature report in China

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