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Pharmaceutical preparation using hydrogen as therapeutic substance and preparation method thereof

A technology of pharmaceutical preparations and substances, applied in the field of medicine, can solve the problems of limited application of hydrogen, immediate use, cumbersome hydrogen, etc., and achieve the effects of favorable industrial production operation, reasonable design, and simple production process

Inactive Publication Date: 2013-06-05
TAISHAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the small amount of hydrogen preparations, although the currently used hydrogen can produce certain curative effects, there are problems that are difficult to solve at the same time: (1) When gas preparations are directly used for administration, it takes a long time to inhale hydrogen from the respiratory tract. It is necessary to prepare 2% hydrogen, but the preparation of 2% hydrogen is cumbersome, and the safety of hydrogen in the application also needs special attention; (2) when using hydrogen aqueous solution for digestive tract or injection medicine, the hydrogen aqueous solution needs to be used immediately, less Over time, the content of hydrogen in the aqueous solution will be significantly reduced, causing the concentration of hydrogen in the body to decrease after use
These problems of hydrogen preparations greatly limit the application of hydrogen as an active substance in clinical treatment

Method used

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  • Pharmaceutical preparation using hydrogen as therapeutic substance and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The weight ratio of each component is 5-10% of iron powder, 75-80% of beeswax, 14-15% of lactose and 0.2-1% of magnesium stearate.

[0024] Weigh the prescribed amount of beeswax, heat it in a water bath to melt it, add the prescribed amount of iron powder under the protection of nitrogen or carbon dioxide gas, stir and mix evenly, pour the suspension into a cold stainless steel plate while it is hot, and let it cool and solidify quickly , and then pulverized through 80 mesh sieve (particle size is 25.4mm / 80), mixed with lactose by equal increment method, added 70% ethanol to make granules, crossed 20 mesh sieve (particle size is 25.4mm / 20) to make granules, Ventilate and dry at 45°C, sieve with 18 meshes (particle size: 25.4mm / 18), granulate, add magnesium stearate for tableting, and obtain the eroded matrix tablet.

Embodiment 2

[0026] The weight ratio of each component is 18-22% of iron powder, 18-22% of aluminum powder, 50-55% of beeswax, 4-5% of starch, 6-8% of lactose and 0.2-1% of magnesium stearate.

[0027] Weigh the prescribed amount of beeswax, heat it in a water bath to melt it, add the prescribed amount of iron powder and aluminum powder under the protection of nitrogen or carbon dioxide gas, stir and mix evenly, pour the suspension into a cold stainless steel plate while it is hot, and make it Rapid cooling and solidification. Then pulverize and pass through 80 mesh sieve (particle size is 25.4mm / 80), mix uniformly with starch and lactose by equal increase method, add 70% ethanol to make granules, pass through 20 mesh sieve (particle size is 25.4mm / 20) to make granules , ventilated and dried at 45°C, granulated with an 18-mesh sieve (particle size: 25.4mm / 18), added magnesium stearate for tableting, and obtained erodible matrix tablets.

Embodiment 3

[0029] The weight ratio of each component is magnesium powder 16-20%, iron powder 20-24%, beeswax 28-35%, stearyl alcohol 18-25%, starch 4-5%, lactose 4-6%, stearic acid Magnesium 0.2-1%.

[0030] Weigh the prescribed amount of beeswax and stearyl alcohol, heat it in a water bath to melt, add the prescribed amount of magnesium powder and iron powder under the protection of nitrogen or carbon dioxide gas, stir and mix evenly, pour the suspension into a cold stainless steel plate while it is hot Let it cool down and solidify quickly. Then pulverize and pass through 80 mesh sieve (particle size is 25.4mm / 80), mix uniformly with starch and lactose by equal increase method, add 70% ethanol to make granules, pass through 20 mesh sieve (particle size is 25.4mm / 20) to make granules , ventilated and dried at 45°C, granulated with an 18-mesh sieve (particle size: 25.4mm / 18), added magnesium stearate for tableting, and obtained erodible matrix tablets.

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Abstract

The invention discloses a pharmaceutical preparation using hydrogen as a therapeutic substance and a preparation method thereof. The pharmaceutical preparation comprises the following components in percentage by weight: 5-40% of substance capable of producing hydrogen gas, 50-80% of pharmaceutical high molecular material for generating a blocking effect and 10-30% of auxiliary molding material. When the pharmaceutical preparation encounters with stomach juice or body water in vivo after being taken, the substance capable of producing hydrogen gas can release hydrogen gas, and the pharmaceutical high molecular material coated around the substance capable of producing hydrogen gas can form a gel type, insoluble or erodible matrix carrier to block the hydrogen gas so as to realize the slow release of hydrogen gas from the carrier, thereby ensuring that the hydrogen gas is slowly absorbed and achieving the effects of slow release and controlled release. Thus, in the invention, the problemthat hydrogen gas acting as an active substance is not suitable for any preparation in the therapeutic process can be solved. By adjusting the sizes and doses of different auxiliary materials, the release rate of the hydrogen gas can be controlled. The invention has the advantages of simple production process and reasonable design and is beneficial to industrial production operation.

Description

technical field [0001] The invention belongs to the field of medical science and technology, and relates to a pharmaceutical dosage form and its preparation technology, in particular to a pharmaceutical preparation based on hydrogen as a therapeutic substance that can generate hydrogen in the body and use the hydrogen as a therapeutic substance and a preparation method thereof. Background technique [0002] The occurrence and development of many diseases are related to oxidative damage, and free radicals and nitrite anions are important mediators of oxidative damage. It is a recognized fact that hydrogen has reducing properties, and theoretically it can combine with hydroxyl radicals and nitrite anions, thereby reducing the oxidative damage caused by them. In recent years, it has indeed been found that the reducing property of hydrogen has biological effects. In 2007, Japanese scholars reported that animals breathing 2% hydrogen can effectively scavenge free radicals, signif...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/00A61K33/06A61K33/26A61K47/30A61K47/44A61K47/10A61K47/12A61K47/14A61K47/38A61K47/36A61P39/06A61P9/10
Inventor 郝吉福赵晓民高允生
Owner TAISHAN MEDICAL UNIV