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Cefaclor sustained-release tablets and preparation method thereof

A technology of cefaclor and sustained-release tablets, which is applied in the fields of pharmaceutical formulations, antibacterial drugs, drug delivery, etc., can solve the problems of frequent taking and inconvenience for patients, achieve long-lasting drug effect, significant curative effect, and reduce the number of taking medicine Effect

Inactive Publication Date: 2011-04-27
山东淄博新达制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Ordinary capsules or tablets of cefaclor are generally taken three times a day, and the number of times of taking them is too many, which brings inconvenience to the patients, but the sustained-release tablets of cefaclor just make up for this defect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Take the production of 1,000 tablets of cefaclor sustained-release tablets with a specification of 375 mg as an example:

[0031] Cefaclor 375mg

[0032] Mannitol 20mg

[0033] Sodium carboxymethyl starch 30mg

[0034] Hydroxypropyl methylcellulose E5 (produced by Dow, USA) 20mg

[0035] Hydroxypropyl methylcellulose K100M (produced by Dow, USA) 30mg

[0036] Polyvinylpyrrolidone K90 5mg

[0037] Magnesium Stearate 6mg

[0038] Preparation:

[0039] (1) Mixing: first mix hydroxypropyl methylcellulose E5 and hydroxypropyl methylcellulose K100M evenly, add sodium carboxymethyl starch and mannitol and mix evenly, then add 100g cefaclor and mix again, Finally, the remaining cefaclor is added, and the above raw materials are fully mixed;

[0040] (2) Pulverization: use the high-efficiency pulverizer to pulverize the good raw materials prepared in step (1);

[0041] (3) Molding: use 5.5% polyvinylpyrrolidone K90 ethanol solution as a binder, make 30-mesh wet granules ...

Embodiment 2

[0047] Take the production of 1,000 tablets of cefaclor sustained-release tablets with a specification of 375mg as an example:

[0048] Cefaclor 375mg

[0049] Mannitol 30mg

[0050] Sodium carboxymethyl starch 15mg

[0051] Hydroxypropyl Methyl Cellulose E5 30mg

[0052] Hydroxypropyl Methyl Cellulose K100M 20mg

[0053] Polyvinylpyrrolidone K90 10mg

[0054] Magnesium Stearate 4mg

[0055] The preparation method is as in Example 1.

[0056] Embodiment 2 tablet release rate

[0057] time

Embodiment 3

[0059] Take the production of 1,000 tablets of cefaclor sustained-release tablets with a specification of 375mg as an example:

[0060] Cefaclor 375mg

[0061] Mannitol 40mg

[0062] Sodium carboxymethyl starch 20mg

[0063] Hydroxypropyl Methyl Cellulose E5 25mg

[0064] Hydroxypropyl Methyl Cellulose K100M 15mg

[0065] Polyvinylpyrrolidone K90 7mg

[0066] Magnesium Stearate 3mg

[0067] The preparation method is as in Example 1.

[0068] Embodiment 3 tablet release rate

[0069] time

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PUM

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Abstract

The invention discloses cefaclor sustained-release tablets, which are characterized by being prepared from the following raw materials in part by weight: 75 parts of cefaclor 3, 20 to 40 parts of mannitol, 15 to 30 parts of sodium carboxymethyl starch, 15 to 30 parts of hydroxypropyl methyl cellulose E5, 15 to 30 parts of hydroxypropyl methyl cellulose K100M, 5 to 10 parts of polyvinylpyrrolidone K90 and 3 to 6 parts of magnesium stearate. The cefaclor sustained-release tablets are a dispersible sustained release preparation taking the hydroxypropyl methyl cellulose (HPMC) as a water-soluble skeleton, after the cefaclor sustained-release tablets are administered, medicaments can be slowly released at an unconstant speed according to the requirement, the release is stable, the ideal blood concentration is provided, an obvious peak-valley phenomenon is absent, the times for taking medicines is reduced, and the cefaclor sustained-release tablets have durable medicament effects and obvious curative effects.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a cefaclor sustained-release tablet and a preparation method thereof. Background technique [0002] Cefaclor is a second-generation oral cephalosporin, which has a strong killing effect on a variety of Gram-positive and Gram-negative bacteria. This product is a broad-spectrum semi-synthetic cephalosporin antibiotic. The activity against penicillinase-producing Staphylococcus aureus, group A hemolytic streptococcus, viridans streptococcus and staphylococcus epidermidis is the same as that of cefadroxil, and the antibacterial effect against non-enzyme-producing staphylococcus aureus and pneumococcus is higher than that of cefadroxil 2 to 4 times stronger. The activity against Gram-negative bacilli, including Escherichia coli and Klebsiella pneumoniae, is stronger than cephalexin, similar to cefadroxil, and the activity against Proteus mirabilis, Salmonella and Shigella ...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/545A61K47/38A61P31/04
Inventor 王煊李华凌楚春锋宫清霞
Owner 山东淄博新达制药有限公司
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