Hydroxyapatite/silk fibroin composite material and preparation method thereof

Abstract

The invention discloses a composite bionic bone material and a preparation method thereof, and in particular relates to a hydroxyapatite / silk fibroin composite bionic material and a preparation method thereof, belonging to the technical field of medical materials. The composite material comprises the following components in percent by mass: 40-60 percent of hydroxyapatite, 10-30 percent of wollastonite and 25-35 percent of silk fibroin. On the basis of tight matching and higher biological property of the hydroxyapatite / silk fibroin material, the wollastonite with better biological property and mechanical behavior is introduced, the mechanical behavior of the composite material is greatly improved without influencing the biological property, the three materials are compounded to obtain a bone tissue coloboma repairing material perfectly combining the mechanical behavior with the bioactivity and compatibility, and the bone tissue coloboma repairing material has better practicability andapplication prospect.

Description

technical field [0001] The invention relates to a composite biomimetic bone material and a preparation method thereof, in particular to a biomimetic material composited with hydroxyapatite and silk fibroin and a preparation method thereof, belonging to the technical field of medical materials science. Background technique [0002] Bone injury and bone defect are common clinical diseases, and the damaged bone can be repaired with endogenous bone or exogenous bone. The repair effect of endogenous bone is very good, but its quantity is very limited and requires a second operation, while the repair effect of exogenous bone is far inferior to that of endogenous bone. The current repair method of exogenous bone has immune rejection, is difficult to degrade, and may cause There are potential pathogens and other side effects, so there is an urgent demand for hard and soft tissue repair materials in domestic and foreign markets. Biomaterials currently used for bone repair are divide...

AI Technical Summary

Problems solved by technology

[0003] Human bone is mainly composed of nano-hydroxyapatite and type I collagen. In the mid-1930s, scientists artificially synthesized hydroxyapatite, which is an artificial bone material with excellent biological properties, but a single component Hydroxyapatite has high brittleness, poor toughness, insufficient mechanical properties, slow degradation and easy migration from the implant site, which limits its use as a human material implant.

At present, using silk fibroin instead of type I collagen to induce the mineralization of nano-hydroxyapatite to prepare biomimetic bone has been widely studied, and a hydroxyapatite / silk fibroin composite material with high biological activity has been obtained. Making silk fibroin and apatite more tightly fused together improves the mechanical properties to a certain extent, but its mechanical strength is still not enough to meet clinical requirements

Most of the currently used bone cement is a composite material of apatite and wollastonite. Wollastonite has high biological activity and compatibility, and in simulated body fluid, hydroxyapatite forms on the surface of calcium silicate. The speed is greater than that formed on the surface of other biological glasses and glass-ceramics, so apatite-wollastonite glass-ceramic has certain osteoconductivity and degradability, and has good biocompatibility and activity. Calcined at high temperature, it has a completely crystalline structure. Although it has high strength, its degradability and toughness are poor

The above two materials still have obvious deficiencies in the combination of mechanical properties and biological properties, which are far from meeting the clinical needs.

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