Hydroxyapatite/silk fibroin composite material and preparation method thereof

A technology of hydroxyapatite and silk fibroin, which is applied in the field of medical materials, can solve the problems of insufficient mechanical strength, poor degradability and toughness, insufficient mechanical properties, etc., and achieves improved mechanical properties, improved mechanical properties, and good practicability. and the effect of the application foreground

Inactive Publication Date: 2011-05-18
SUZHOU UNIV
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Problems solved by technology

[0003] Human bone is mainly composed of nano-hydroxyapatite and type I collagen. In the mid-1930s, scientists artificially synthesized hydroxyapatite, which is an artificial bone material with excellent biological properties, but a single component Hydroxyapatite has high brittleness, poor toughness, insufficient mechanical properties, slow degradation and easy migration from the implant site, which limits its use as a human material implant.
At present, using silk fibroin instead of type I collagen to induce the mineralization of nano-hydroxyapatite to prepare biomimetic bone has been widely studied, and a hydroxyapatite/silk fibroin composite material with high biological activity has been obtained. Making silk fibroin and apatite more tightly fused together improves the mechanical properties to a certain extent, but its mechanical s

Method used

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  • Hydroxyapatite/silk fibroin composite material and preparation method thereof
  • Hydroxyapatite/silk fibroin composite material and preparation method thereof
  • Hydroxyapatite/silk fibroin composite material and preparation method thereof

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Example Embodiment

[0022] Example 1: See attached figure 1 This embodiment provides a method for preparing a hydroxyapatite-wollastonite / silk fibroin composite biomimetic material, and the steps are as follows:

[0023] 1. The concentration of each preparation is 0.5mol / LCa(NO 3 ) 2 Solution and Na 2 SiO 3 Solution, 0.5% polyvinyl alcohol solution as a dispersant added to Ca(NO 3 ) 2 In the solution, add Na dropwise while stirring 2 SiO 3 Solution. After it is fully reacted, the obtained precipitate is washed with deionized water and absolute ethanol, dried and calcined to obtain wollastonite powder.

[0024] 2. According to the mass percentages of silk fibroin, wollastonite, and hydroxyapatite in the composite powder as 30%, 20%, and 50% respectively, to prepare 10g composite powder, 3g degummed silk should be weighed separately. Of silk fibroin fiber, 2g of wollastonite powder, and 11.76g of Ca(NO) needed to synthesize 5g of hydroxyapatite 3 ) 2 ·4H 2 O and 11.36g Na 3 PO 4 ·12H 2 O; Na 3 PO 4 ·12...

Example Embodiment

[0029] Embodiment 2: This embodiment provides a method for preparing a hydroxyapatite-wollastonite / silk fibroin composite biomimetic material, and the steps are as follows:

[0030] 1. The concentration of each preparation is 0.5mol / LCa(NO 3 ) 2 Solution and Na 2 SiO 3 Solution, 0.5% polyvinyl alcohol solution as a dispersant added to Ca(NO 3 ) 2 In the solution, add Na dropwise while stirring 2 SiO 3 Solution. After it is fully reacted, the obtained precipitate is washed with deionized water and absolute ethanol, dried and calcined to obtain wollastonite powder.

[0031] 2. According to the mass percentages of silk fibroin, wollastonite, and hydroxyapatite in the composite powder as 30%, 30%, and 40%, respectively, to prepare 10g composite powder, 3g silk is degummed. Silk fibroin fiber, 3g wollastonite powder, and 9.41g Ca(NO) required to synthesize 4g hydroxyapatite 3 ) 2 ·4H 2 O and 9.09g Na 3 PO 4 ·12H 2 O; Na 3 PO 4 ·12H 2 O add 50ml deionized water to make 0.48mol / L Na 3 PO...

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Abstract

The invention discloses a composite bionic bone material and a preparation method thereof, and in particular relates to a hydroxyapatite/silk fibroin composite bionic material and a preparation method thereof, belonging to the technical field of medical materials. The composite material comprises the following components in percent by mass: 40-60 percent of hydroxyapatite, 10-30 percent of wollastonite and 25-35 percent of silk fibroin. On the basis of tight matching and higher biological property of the hydroxyapatite/silk fibroin material, the wollastonite with better biological property and mechanical behavior is introduced, the mechanical behavior of the composite material is greatly improved without influencing the biological property, the three materials are compounded to obtain a bone tissue coloboma repairing material perfectly combining the mechanical behavior with the bioactivity and compatibility, and the bone tissue coloboma repairing material has better practicability andapplication prospect.

Description

technical field [0001] The invention relates to a composite biomimetic bone material and a preparation method thereof, in particular to a biomimetic material composited with hydroxyapatite and silk fibroin and a preparation method thereof, belonging to the technical field of medical materials science. Background technique [0002] Bone injury and bone defect are common clinical diseases, and the damaged bone can be repaired with endogenous bone or exogenous bone. The repair effect of endogenous bone is very good, but its quantity is very limited and requires a second operation, while the repair effect of exogenous bone is far inferior to that of endogenous bone. The current repair method of exogenous bone has immune rejection, is difficult to degrade, and may cause There are potential pathogens and other side effects, so there is an urgent demand for hard and soft tissue repair materials in domestic and foreign markets. Biomaterials currently used for bone repair are divide...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/42
Inventor 周竹发王淑梅赵松
Owner SUZHOU UNIV
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