Compound traditional Chinese medicine extract for preventing and treating lipid metabolism disorder and preparation method thereof

A lipid metabolism disorder and compound Chinese medicine technology, applied in metabolic diseases, drug combinations, medical preparations containing active ingredients, etc., can solve problems such as unclear active ingredients, difficult product quality, complex chemical components, etc., and achieve reliable product quality. Controlling, increasing the content of active ingredients, and stabilizing the preparation process

Active Publication Date: 2012-04-18
青岛百里才鑫医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a comprehensive solution based on the defects of the existing "Compound Zhenzhu Tiaozhi Decoction", which have complex chemical components, unclear active ingredients, difficult to obtain effective control of product quality in practical applications, and too many invalid components. A compound traditional Chinese medicine extract for preventing and treating lipid metabolism disorder

Method used

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  • Compound traditional Chinese medicine extract for preventing and treating lipid metabolism disorder and preparation method thereof
  • Compound traditional Chinese medicine extract for preventing and treating lipid metabolism disorder and preparation method thereof
  • Compound traditional Chinese medicine extract for preventing and treating lipid metabolism disorder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Preparation of total extracts of traditional Chinese medicine compound

[0032] The two medicines of Ligustrum lucidum, Baizhu, Eucommia, Panax notoginseng, Daji, Salvia miltiorrhiza, Coptidis, and Bergamot (weight ratio 1:1:1:2:1:2:1:1) Crushed into coarse powder, and extracted three times with 60% ethanol by volume 10 times, 8 times and 6 times of the amount of medicinal materials, respectively, for 2 h each time, combined the extracts, recovered ethanol, and made the concentration of the ethanol extraction part to be 1 ml, which is equivalent to 1 ml. g crude drug; the rest of the medicinal materials in the recipe are extracted three times with eight times, six times and four times the amount of water, respectively, for 2 h each time, the three water extracts are combined, and concentrated under vacuum to 1 g medicinal materials / ml extract , the water-extracted part and the previous alcohol-extracted part were combined to obtain the total extract of tradi...

Embodiment 2

[0033] Example 2 Preparation of Extraction Parts of Compound Total Extract

[0034] Extract once with 15 times the volume of petroleum ether of the total extract of the compound recipe, and separate the petroleum ether layer; then extract twice with 10 times the volume to obtain the petroleum ether layer, combine the petroleum ether extracts three times, recover the petroleum ether, and then press , and vacuum-dried at 60°C to obtain the extraction site A;

[0035] The extracted extract was then extracted with 15, 10, and 8 times of ethyl acetate, respectively, to obtain the ethyl acetate extraction part, the solvent was recovered, and vacuum-dried at 0.07 MPa and 60 ° C to obtain the compound extract part B;

[0036] The extracted extract was then extracted with 15, 10, and 8 times the amount of n-butanol of the total extract, respectively. The extracts were combined to recover n-butanol, and the extract was vacuum-dried at 0.07 MPa and 75 ° C to obtain a compound formula ...

Embodiment 3

[0042] Example 3 Preparation method of compound traditional Chinese medicine extract capsules

[0043] The extracts are combined according to the following parts by weight:

[0044] 1 piece of effective extraction part A

[0045] 2 copies of effective extraction part B

[0046] Effective extraction site C 5 copies.

[0047] The extracts in the above proportions, the extraction part A and the same amount of starch are mixed uniformly, then mixed with the extraction part B, and finally mixed with the extraction part C, the three are mixed uniformly and then dry granulation, after drying under reduced pressure, granulate, Filled No. 2 capsules, polished, quality-checked packaging.

[0048] Measure the obtained capsule with HPLC method, and it contains each active ingredient content and the results are shown in Table 1:

[0049] Table 1 Determination results of FTZCE capsules by HPLC

[0050]

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Abstract

The invention discloses a compound traditional Chinese medicine extract for preventing and treating lipid metabolism disorder. The compound traditional Chinese medicine is prepared from the following eight traditional Chinese medicines: red sage root, glossy privet fruit, coptis, thistle, eucommia, bighead atractylodes rhizome, notoginseng and fingered citron. The preparation method comprises thefollowing steps: extracting the raw medicines with C1-3 alcohol and/or water, and then, mixing all extracts; extracting the total extracts with organic solvents of different polarities to obtain effective parts of different polarities; and mixing the effective parts to obtain the compound traditional Chinese medicine for preventing or treating lipid metabolism disorder. By the preparation method disclosed by the invention, a large number of ineffective chemical components in the traditional Chinese medicine can be removed, thereby reducing the influence of the ineffective components on product processing and preparation quality, and determining the effective components in the compound traditional Chinese medicine. The compound traditional Chinese medicine extract has the advantages of stable preparation process and controllable product quality, the compound traditional Chinese medicine extract is suitable for being in industrial preparation and has improved and stable effect.

Description

technical field [0001] The invention relates to the field of compound Chinese medicines, in particular to a compound Chinese medicine extract for preventing and treating lipid metabolism disorders and a preparation method thereof. Background technique [0002] Chinese patent 200410051250.4 discloses a drug for treating hyperlipidemia, named "Fufang Zhenzhu Tiaozhi Fang" (FTZ), composed of Ligustrum lucidum, Atractylodes macrocephala, Eucommia, Sanqi, Daji, Salvia, Coptidis, Bergamot Composition of traditional Chinese medicine. It is a prescription with more than ten years of clinical application experience, and it has achieved ideal curative effect in the treatment of hyperlipidemia. Experimental research also shows that this prescription has a good lipid-lowering effect on experimental dietary hyperlipidemia in rats. The prescription Patent has been granted. [0003] Although the compound has a good effect on regulating blood lipids, it is a traditional Chinese medicine ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/575A61P3/06A61K31/015A61K31/047A61K31/192A61K31/20A61K31/201A61K31/343A61K31/365A61K31/37A61K31/4375A61K36/752A61K31/56A61K31/704A61K31/7048
CPCA61K31/047A61K31/201A61K31/20A61K36/46A61K36/53A61K31/37A61K31/015A61K36/258A61K36/284A61K31/365A61K31/192A61K36/718A61K31/045A61K31/575A61K31/4375A61K36/28A61K31/7048A61K36/752A61K31/343A61K31/56A61P3/06A61K2300/00
Inventor 郭姣何伟
Owner 青岛百里才鑫医药科技有限公司
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