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Ferroferric oxide-silicon dioxide-thymine nanoparticles and preparation method and application thereof

A technology of ferric tetroxide and nanoparticles, which is applied in the analysis, emulsion delivery, and contrast agent of nuclear magnetic resonance/magnetic resonance imaging by nuclear magnetic resonance, etc., can solve the problem of rare mercury ions, etc. The effect of short response time and convenient operation

Inactive Publication Date: 2011-06-08
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are few reports on the detection of mercury ions using magnetic nanoparticles.

Method used

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  • Ferroferric oxide-silicon dioxide-thymine nanoparticles and preparation method and application thereof
  • Ferroferric oxide-silicon dioxide-thymine nanoparticles and preparation method and application thereof
  • Ferroferric oxide-silicon dioxide-thymine nanoparticles and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 synthetic Fe 3 o 4 Nanoparticles:

[0038] Take ferric acetylacetonate (1.060g, 3mmol), mix phenyl ether (15mL) and oleylamine (15mL, 6mmol), and heat to 180°C under nitrogen protection (nitrogen can be replaced by an inert gas such as helium), at this temperature After reacting for 30 minutes, the temperature was raised to 300° C., and the reaction was carried out at this temperature for 1 hour. The obtained product was washed and centrifuged with absolute ethanol, and dried in vacuum to obtain Fe 3 o 4 magnetic nanoparticles. Electron microscope transmission picture as figure 1 As shown, Fe 3 o 4 The magnetic nanoparticles are well dispersed in n-hexane (or organic solvents such as cyclohexane), with an average size of about 8.25nm, which belongs to the size range of superparamagnetic, uniform in size, and has good monodispersity. Electron diffraction pattern as Figure 4 shown.

Embodiment 2

[0039] Embodiment 2 synthetic Fe 3 o 4 @SiO 2 -NH 2 Nanoparticles (silicon-coated and amino-linked):

[0040] Get the Fe that embodiment 1 obtains 3 o 4 10mg of nanoparticles, 35ml of cyclohexane and 2.0g (4.64mol) of α-(4-nonylphenyl)-ω-hydroxyl-poly(oxygen-1,2-diethylene) (i.e. Igepal CO-520), Mix and stir evenly; add 0.35ml 25wt% ammonia water to adjust the pH value to 7.5-8.0, then add 0.2mL tetraethyl orthosilicate (186mg) and 0.035ml 3-aminopropyl-triethoxysilane (the content is 98wt%) , 33 mg), stirred for 24 to 48 hours.

[0041] Add 50mL absolute ethanol and centrifuge to obtain Fe 3 o 4 @SiO 2 Nanoparticles; electron microscope transmission picture as figure 2 As shown, the particle size is uniform and has good monodispersity.

Embodiment 3

[0042] Embodiment 3 measures amino density

[0043] Get the Fe that embodiment 2 obtains 3 o 4 @SiO 2 -NH 2 26 mg of nanoparticles and 9-fluorenylmethyl chloroformate (Fmoc-Cl) (60 mg, 0.2 mol) were dissolved in 5 mL of anhydrous N, N-dimethylformamide (DMF) in N 2 React under protection for more than 12 hours. Freeze-dry after centrifugation with anhydrous methanol. The dried nanoparticles are about 20 mg. Add 1.5 mL of anhydrous DMF and 0.5 mL of piperidine, and sonicate for 30 min. Centrifugal 15min then, get precipitation, obtain the nanoparticle (Fe 3 o 4 @SiO 2 -NH 2 Nanoparticles). Take the clear liquid to measure ultraviolet light, and calculate Fe 3 o 4 @SiO 2 The number of amino groups on the surface of nanoparticles; the density of amino groups was detected to be 1.35*10 -4 mol / g.

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Abstract

The invention relates to the field of magnetic resonance contrast agents and nuclear magnetic resonance sensors and discloses ferroferric oxide-silicon dioxide-thymine nanoparticles which have water solubility, good monodispersity and superparamagnetism, and the average particle size is 10-20nm. The preparation method comprises the steps of preparing the Fe3O4 nanoparticles by high-temperature pyrolysis, wrapping silicon dioxide, connecting with amino groups, and further connecting with thymine. The nanoparticles can be used for preparing the magnetic resonance contrast agents and preparing the nuclear magnetic resonance sensors for detecting mercury ions.

Description

technical field [0001] The invention relates to the field of magnetic resonance contrast agents and nuclear magnetic resonance sensors, in particular to a ferric oxide-silicon dioxide-thymine nanoparticle and a preparation method and application thereof. Background technique [0002] The reason why nuclear magnetic resonance has become one of the main detection methods popular today is mainly due to two reasons: (1) MRI (magnetic resonance imaging, or magnetic imaging) can provide clear spatial resolution and can obtain detailed information on physiological tissues and organs; (2) It is a noninvasive research method. MRI can realize "non-invasive" and clear 3D imaging of cells or human tissues, and plays an important role in the fields of physics, chemistry, biology and clinical medicine. It can be used to observe the structure and properties of small molecules, as well as the anatomical structure and function of living animals and even humans. It is precisely because of i...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/06G01N24/08
Inventor 杨仕平田志卿杨红
Owner SHANGHAI NORMAL UNIVERSITY
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